Earlier this year, I was interviewed by a major online bodybuilding site (the interview was titled “Chemically Insane”), and in
that interview, I predicted that various peptides would become the newest trend in performance enhancing drugs. For the most part, I was
correct, and now they’re very popular and widely available, although still relatively new.
So,several months ago, I began my experimentation with various peptides, mostly with the goal of figuring out the best way to use them. My last
major article examined my experiences with the two most popular peptides (IGF
and MGF) currently on the market. This time around, I’m going to tell you about my experience with Hexarelin and GHRP-6,
two lesser known peptides. With Lr3IGF-1, the use and goals of use is pretty straightforward…you
pretty much use it to gain muscle and lose fat; on rare occasions, people use it to rehab an injury (I actually provided a full rehab
protocol using IGF-1 in my first e-book). With MGF,
it’s even simpler…you use it to increase muscle size, period.
Using the other peptides is a bit more complicated, and there are a couple of other reasons you might want to consider using them…but
I’m getting a bit ahead of myself. The first thing I do when I’m researching a new anabolic is to jump on the internet and
do some research in all of the available medical databases, and exhaust every search engine imaginable with keywords related to the new
compound. The next thing I do is typically to get a couple of vials and try it for myself. I’m in a very unique position with regards
to trying new compounds; in the case of several compounds (Esterless Boldenone, Masteron
Enanthate, Stealth Injectables, etc…) I was actually able to try the products before they were released to the
general public. In the case of Hexarelin and GHRP-6, I have had the opportunity to experiment with them for the past few months.
When I first received my vials of GHRP-6 and Hexarelin,
I did what most people probably do…I reconstituted them, shot first, and asked questions later. I thought it would be a great
idea to fire up 600mcs of GHRP-6 just before a heavy max effort deadlift session. Bad idea. I have a 45 minute drive to my gym (I
happen to workout at a military academy, where I coach), and halfway there, I started to get a bit hungry. No problem, right?
We’ve all worked out a bit hungry…well, that’s what I thought at first. Then when I hit about 400lbs
into my deadlifts, I started getting dizzy…I broke into a cold sweat, and I had to sit down. I rushed to get some simple carbs
into my body as quickly as possible, thinking that I was going hypoglycemic. Ok…I wasn’t going hypoglycemic, but
it was pretty bad. That workout was shot. Still, I was wondering if I could actually slip into some kind of severe hypoglycemia from a shot
of GHRP-6…it certainly felt like I could.
So, naturally, I was interested, and did some experimenting. I waited a day and invited a friend over to my place…then I did another
shot of 600mcg (split bilaterally, 300mcg into each leg, as a subcutaneous shot). Then we sat around and waited, with a bunch of
simple carbs ready. I got hungry, I was uncomfortable, and it wasn’t too much fun, but we sat there for a good couple of
hours, and I didn’t pass out (in case you’re wondering, the friend was there to drive me to the hospital, in case I
actually did pass out). Ok…so that settles that. Originally, I thought that maybe GHRP-6 operated by inducing some kind of mild
hypoglycemia (hypoglycemia increases GH output). But that’s not how it actually works…
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Growth
Hormone Releasing Peptide- 6 (GHRP-6) is a synthetic
hexapeptide which stimulates the release of Growth Hormone. It
accomplishes this by two totally separate mechanisms. On the one hand,
it amplifies your body’s natural Growth
Hormone Releasing Hormone (GHRH) signal transduction
pathway, and on the other hand, acts as a functional
antagonist of the hormone which causes inhibition of GH secretion
(somatostatin) (1-3).
GHRP-6 also
has the benefit of being able to directly stimulate the anterior
pituitary gland, resulting in increased GH release. So although my
initial thoughts on the mechanism of action for this stuff was wrong, I
was enthused when my research revealed that GHRP-6 induced GH secretion
occurs by several mechanisms. Most importantly, those mechanisms are
the induction of GHRH release from the hypothalamus,
stimulation of GH release from somatotrophs, joint actions of GHRH and
antagonism of somatostatin, and finally by pronounced antagonism of
somatostatin action on somatotrophs (1-4). However, it bears
clarification that GHRP-6 is not dependant on the GHRH
pathway…it can boost your growth hormone levels without
necessarily needing to elevate GHRH. This is important because if that
pathway has been inhibited by long term GH use, GHRP-6 can still get
your body producing and releasing GH.
Additionally, this peptide can also act on the central nervous system,
(4) which can provide added benefits in neuroprotection as well as
muscular strength increases for the user. Much of the strength
increases we see with Anabolic Steroids in the Dihydrotestosterone
family are suspected to be through a similar stimulation of the Central
Nervous System. In my experience with GHRP-6 use, strength levels
typically go up within the first week of starting out.
Increases in Growth Hormone levels in the body are typically
accompanied by strength increases, muscle hypertrophy (growth), and
lipolysis (fat loss). Other results experienced with increased GH
levels are recuperative effects on joints and injuries; connective
tissue strengthening and bone mineral density improvements are
commonplace. Enhanced GH secretion also leads to the liver secreting
more IGF-1 (Insulin-Like
Growth Factor 1), which is thought to be the primary anabolic
mechanism of action for Growth Hormone. In the case of GHRP-6, I gained
quite a bit of weight when I was running it at the 600mcg/day level. I
think that this was probably due to overfeeding that almost always
accompanied my shot contributed to this weight gain. I gained about
12lbs in 2 weeks. I think that the same way people often throw EQ into
bulking cycles to increase appetite stimulation, I would suggest using
GHRP-6 instead. It’s not anywhere near as anabolic, but the
appetite increase is far above anything I’ve ever experienced
with any anabolics.
The women I know who have used GHRP-6
all had to discontinue its use because it was making them gain weight
too quickly. But then again, most of the women who I know are national
level (or professional) physique competitors, and at most need an
additional 5-10lbs of muscle at most. GHRP-6 just put too much weight
on them too quickly.
After experimenting with GHRP-6
for weight gain, I lowered the dose substantially and used it to help
rehab a knee injury that had been bothering me for a couple of years. In
this case, I lowered it to 100mcg/day, shot sub-q into the knee (ouch!).
At this dose you won’t find the extreme hunger that a high dose of it
usually causes, and a 5mg bottle of GHRP-6 is going to last for months,
and I’m confidant that it’s going to be enough to rehab virtually any
injury (in my case, I had done extensive damage to my knee over the
years, culminating in a traumatic injury playing on turf…which resulted
in my semi-retirement from competitive athletics). Anyway, I combined
GHRP-6 with a knee rehab protocol designed by an M.A., and
advice from one of my research assistants, who has a degree in Sports
Medicine. Taken this way, I used GHRP-6, and rehabbed my knee to almost
where it was prior to my beginning my career in athletics. If you have
an injury, find yourself a good rehab protocol, and try a low dose of
GHRP-6. I bet you’ll be surprised.
Oh…and this brings me to another point. I’m sure
most people subscribe to the theory that peptides only last for a
couple of weeks in their reconstituted form. Well, after I had my
GHRP-6 reconstituted for well over a month, I tried a shot at my old
600mcg dose, and guess what happened? Yeah, I got a huge increase in
appetite within the hour. This tells me that we’re really
underestimating the amount of time that a reconstituted peptide can
retain its potency. I’m betting we have months, not weeks.
Since GHRP-6 acts directly on the feedback loop which signals the
inhibition of GH release, it has been used immediately following either
GH
or IGF-1 cycles, to recover natural GH production by
inhibiting somatostatin action. It has also been used concurrently with
those compounds to negate some of the effects of those compounds on |
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