Somatomedin C is a protein found in humans and is commonly termed as Insulin-like growth factor 1 (IGF-1). It is one of the most important hormones responsible for growth in children and has a molecular structure and size similar to that of Insulin. It has a molecular weight of 7649 daltons and consists of a peptide chain with 70 amino acids in a single chain having three intramolecular disulphide bridges.
It is associated with the peptide family, commonly identified as the growth factors. Known to be a highly anabolic hormone, it is produced in liver and the peripheral tissues particularly in the cells of skeletal muscles. The presence of the Human Growth Hormone (HGH) in the body is considered to trigger the release of IGF-1 as its response. It is one of the most sought after substances by bodybuilders for the reason that it initiates the development of muscles in a very short period. As a result of rigorous training, the body experiences an increase in the Growth Hormone (GH) as well as the IGF-1 which causes the muscle cells to grow. Where GH is considered to have very strong anabolic properties, it is IGF which is believed to be responsible for its primary anabolic nature.
Growth hormone is mainly produced in the anterior pituitary gland which then flows into the blood stream stimulating the liver to produce IGF-1. As a result, IGF-1 then leads to the systemic body growth of all the cells in the body mainly those of the skeletal muscles, cartilage, bone, liver, kidney, nerves, skin, hematopoietic cell and the lungs. Apart from IFG’s insulin-like effects, IGF-1 also initiates regulated cell growth and development in the nerve cells and cellular DNA synthesis.
Deficiency of any of these two substances causes stunted growth in children who are then given recombinant GH to restore their condition. People suffering from IGF-1 often suffer from Laron syndrome (Laron’s dwarfism) and are treated with recombinant IGF-1.
Normally 98% of IGF-1 is always seen to be bound to one of 6 binding proteins (IGF-BP). The protein responsible for 80% binding of IGF is IGFBP-3and is bound to it in 1:1 molar ratio.
When administered, IGF-1 leads to the building of new muscle tissue by initiating the synthesis of protein along with the retention of nitrogen in the body. The prime functions associated with this are hyperplasia, which causes an increase in the muscle tissue and mitogenesis or the growth of new muscle fibers. This makes IGF -1 a highly favoured option for bodybuilders and power lifters seeking not only their muscle development but growth of muscle fibers as well.
Another benefit of employing IGF-1 is that it has a strong effect on the lipid metabolism of the body. In other words, it also plays a significant role in burning the body fat at a relatively fast rate. IFG-1 is also known to be a neuroprotector as well as a neuropromotor and finds its use in the improvement of functions related to the mind like reflexes, memory and ability to learn.
IGF-1 is employed as one of the most important substances required for the production of connective tissue in the joints, thereby ensuring appropriate bone density.
Being a highly potent drug for the development of muscle mass and fat-cutting, IGF’s Lr3 IGF-1 version is also considered to be equally powerful. Here Lr3IGF-1 stands for Long R3 Insulin-like Growth Factor-I or Long R3IGF-I. It is a peptide of 83 amino acid analog of human IGF-I consisting of an entire human IGF-1 sequence. However, the only difference is that there is a substitution of an Arg for the Glu at position 3 and 13 amino acid extension at the N-terminus of the peptide. It is for this reason that Long R3IGF-I is comparatively considered to be a more potent drug.
Some factors believed to cause changes in the levels of growth hormone (GH) and IGF-1 are the user genetic make-up, time of the day it is taken, age, sex, exercise status, stress level, nutrition level and body mass index (BMI). Reduction in IGF-1 signaling is also associated with the contribution of ‘anti-aging’ effects during calorie restriction phase.
A word of caution here is that increased use of IGF is often associated with enhanced risk of cancer.
Tags: bodybuilders, growth hormone, human growth hormone, IGF-1, insulin-like growth factor 1, Somatomedin C
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