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Archive for  August 2009

Friday 28, Aug 2009

New anabolic steroid alternative claims it is better than anabolics

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New anabolic steroid alternative claims it is better than anabolicsPermadrol is an anabolic steroid alternative originally created as a testosterone therapy pill for men with low testosterone level. It has recently been introduced in the US marketplace, although FDA has not officially endorsed this product.

Permadrol is manufactured by Wesley-Adams but has been discovered by the underground bodybuilding community. It is legally sold in the US in some clinics and gyms but not in stores like GNC or Vitamin Shoppe-like stores.

Permadrol, however, must be used in conjunction with a nutritional and exercise program and must not be used for prevention or treatment of a disease.

The product is specifically designed for men with low testosterone levels, especially those 35 years and older. This product intends to combat effects of low testosterone levels such as decrease in muscle mass, lack of energy, decrease in bone density, low confidence, lower sex drive, depression, fatigue, and low muscular and sexual performance.

Aside from increasing testosterone levels, Permadrol is also used by bodybuilders to counteract the side effects of steroid cycle.

It works the same as the drug Human Chorionic Gonadotropin (hCG). It signals the body to produce more testosterone. Additionally, Permadrol’s effect to the body is more natural and therefore, it exhibits lesser side effects to users.

Thursday 27, Aug 2009

GH termed illegal for off-label usage

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GH termed illegal for off-label usage Off-label distribution or provision of growth hormone for treating aging and other forms of age-associated illness is illegal in the United States as per a report in the Journal of the American Medical Association.

The authors of this study were Dr. Thomas Perls, Director of the New England Centenarian Study at Boston Medical Center and associate professor of medicine at Boston University School of Medicine; Dr. Neal Reisman, clinical professor of plastic surgery at Baylor College of Medicine and associate chief of plastic surgery at St. Luke’s Episcopal Hospital, who is also an attorney; and S. Jay Olshansky, professor of epidemiology at the University of Illinois at Chicago School of Public Health.

It was remarked by Reisman that this study paper can prove its worth by creating enough awareness about legal issues surrounding improper distribution, marketing, and discouraging criminal practices in respect to growth hormone.

Thursday 27, Aug 2009

Additional substances banned by FDA

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Additional substances banned by FDA Pro-hormones are substances that when ingested are converted by the body into anabolic hormones. They produce similar effects as that of anabolic steroids. Some of the dietary supplements present in the market today,which contain pro-hormones were Tren, Havoc and Spawn. They seemed a little harmless over anabolic steroids because they can be purchased over the counter without a doctor’s prescription, as long as you’re 18 years old and above.

Aside from giving the same effects as anabolic steroids, pro-hormones also give out the same stress level to the liver as steroids do. It can also produce the same side effects as steroids such as estrogenic effects and alteration of hormonal levels in the body.

A college football athlete shared his experience with Tren, a brand of pro-hormone. He experienced sleepless nights, excessive hunger and a severe acne case after his post-cycle therapy.

In July, pro-hormones were included in the FDA’s list of banned substances. It is now illegal to distribute but those with a hidden agenda would always find a way to obtain it.

High school and college coaches like Gary Ekegren, head man at Missoula Big Sky, hopes the ban could lead to decreased use of pro-hormones in young athletes.

According to the Missoulian:

Bulking up has always been a part of football, but some athletes have been using banned substances to achieve their goals. Pro-hormone, a substance with effects similar to steroids, was recently banned by the FDA.

Thursday 27, Aug 2009

Second case of steroids use at the World Championships

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Second case of steroids use at the World ChampionshipsIn Berlin, the second athlete to test positive steroids use for was Amaka Ogoegbunam, the 19-year-old hurdler from Nigeria. She tested positive for Metenolone use during an in-competition testing on August 18, 2009.

The Nigerian raced in the first round of women’s 400 meters hurdles. However, she was disqualified from joining the semi-final. She was supposed to run in the 4 x 400 meter relay.

Ogoegbunam faces two-year suspension from competition and is currently under provisional suspension. It was her first time to test positive for steroids use.

According to International Association of Athletics Federations (IAAF) spokesperson Nick Davies, she did not request further for a B sample test.

The first reported athlete to test positive for steroids use in the world championships was Jamel Chatbi, the Moroccan steeplechaser, who was disqualified from participating in the finals after testing positive for Clenbuterol. He had to withdraw from the 3,000 meter steeplechase competition.

The International Association of Athletics Federation (IAAF) will continue to test a total of 1,000 athletes during the championships. The 2009 world championships started last August 15, 2009 in Berlin until August 22, 2009.

According to Eurosport:

Nigeria’s Amaka Ogoegbunam, who competed in the women’s 400 metres hurdles at the world championships and was due to run in the 4×400 relay, has tested positive for the steroid metenolone, the IAAF said Friday.

Thursday 27, Aug 2009

Two correction officers under investigation for steroids use

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Two correction officers under investigation for steroids useAt this time, the identities of the two correction officers were still not released. According to Community Narcotics Enforcement Team (CNET) captain, Robert Patnaude, they still do not have enough information to release regarding their investigations.

The New York State Police were still performing on-going investigations on the two officers who allegedly possessed and used steroids. The two officers were assigned at the Oneida County jail. One officer is a long-time member of the Sheriff’s office and the other was more recently hired.

In a statement made by M.A. Peter Paravati, Oneida County Undersheriff, the two officers were on leave while the investigation is pending. The Sheriff’s office learned of the investigation only after the officers begun taking their leaves. He himself could not make any administrative action regarding the said incident because he had not yet learned sufficient details regarding the investigation.

Officials and authorities would not want to comment regarding the incident including Oneida County District Attorney Scott McNamara and officials of the New York State Correctional Officers and Police Benevolent Association.

Oneida County jail has more than 500 hundred employees,most have good work ethics, however, there a few who make mistakes, admitted Paravati.

From UticaOD:

Two correction officers at the Oneida County jail currently are under investigation by New York State Police regarding the alleged possession and use of steroids, officials confirmed Friday.

Wednesday 26, Aug 2009

Higher rejection incidence following early steroid withdrawal

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Higher rejection incidence following early steroid withdrawal  According to a new study on early steroid withdrawal following liver transplantation, it has been revealed that there is a high incidence of rejection and a low incidence of intolerance that necessitates treatment for diabetes. This first double-blind placebo-controlled study was conducted to examine the effects of early steroid elimination.

The results of this study were published in an issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS).

From Eurekalert.org:

The normal course of treatment after liver transplantation includes calcineurin inhibitors (a class of immunosuppressants) and steroids to minimize rejection and improve survival rates, but the long-term complications of these drugs can be fatal. Steroid use in particular can lead to diabetes, high cholesterol and hypertension, which increase the risk of heart disease, and can lead to death. Several previous studies have reported that early withdrawal from steroids reduced the incidence of these side effects, but that rejection increased, although it could be controlled with steroid pulse therapy (in which high doses of steroids are administered intravenously for a short period of time). The current multicenter study was the first prospective double-blind, placebo-controlled trial to compare early steroid withdrawal with continued use.

Led by Georges-Philippe Pageaux, of the Centre Hospitalier University St.-Eloi in Montpellier, France, the study examined 174 patients in 15 French liver transplantation centers over a 14-month period from December 1999 to August 2001. The patients were randomly divided into two groups seven days following transplant: 90 of them continued to receive steroids for six months, while 84 received a placebo starting at day 14 (following 7 days of tapering from steroids). At the end of six months, 22 patients in the steroid group (24.4 percent) and 32 patients in the placebo group (38.1 percent) experienced acute rejection. Although there was no statistical difference in the two groups for high cholesterol and hypertension, 22.2 percent of patients in the steroid group developed diabetes compared with 14.3 percent of placebo patients. At the end of 12 months, the incidence of acute rejection was 25.6 percent in the steroid group versus 39.3 percent in the placebo group, but there no longer a difference in diabetes between the two groups.

The authors concluded that early steroid withdrawal at day 14 is not considered to be completely safe in terms of rejection but it was also found that it is efficient in terms of glucose tolerability.

Wednesday 26, Aug 2009

Relationship between sex steroids, inflammation, and platelet aggregation

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Relationship between sex steroids, inflammation, and platelet aggregationHormone therapy has come out as a risk factor in women for venous thrombosis, which is a blood clot forming deep inside the vein. Despite the fact that this ailment is rare, it is known to increase exponentially during menopause and is considered to be fatal.

The study was undertaken by a team of Mayo Clinic researchers, led by Virginia Miller. The team developed a novel concept that is all about using blood platelets for defining thrombotic risk. The research was discussed by Miller at a conference sponsored by the American Physiological Society (APS).

From News-Medical.Net:

The study focuses on platelets, which are cellular fragments in the blood. Platelets have a phenotype (i.e., a set of physical characteristics) that change and it is known that hormones affect platelet change. The team is examining what happens to platelets in the presence of hormones , whether platelet microvesicles occur more frequently as a result, if a change is triggered by infection, and what may account for thrombotic risk in one woman over another.

The study design takes into account the researchers, belief that three forces , an injury, a platelet effect at the injury, and the inflammation that affects the platelet and the vessel wall , are involved in the development of thrombotic risk.

The study builds on the team’s earlier findings in an animal model. They are applying the earlier results to a human population for the first time using blood taken from the women enrolled in the KEEPS trial. Depending upon the results from this group, a larger trial of 720 samples will be examined.

Depending on the results of this study, the researchers may examine the relationship of platelet activity, inflammation, and cardiovascular risk (CV) in men. It is well known that men have a higher risk factor for cardiovascular disease (CVD) than do females, and arterial clots, rather than venous clots, are a greater concern in the presence of CVD. Since men carry the female hormone estrogen as well as the male hormone testosterone, some of the findings from the female KEEPS study may shed light on these mechanisms involving men.

It was concluded by Miller that this kind of research brings the medical fraternity closer to defining the risk profiles for a certain health issue with a hope that it will lead to tools that can facilitate doctors to offer hormonal therapy for female patients in commensuration with a risk for venous thrombosis.

Wednesday 26, Aug 2009

Abuse of Ritalin on a rise among teenagers

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Abuse of Ritalin on a rise among teenagersRitalin has emerged as the obvious choice of a huge majority of sleep-deprived teenagers who are struggling to make the grade.

Undergraduates, as well as high school SAT-takers, are turning to prescription stimulants for boosting the levels of concentration to stay ahead of competition without feeling the heat of burning the oil in night.

According to a study by the University of Michigan Substance Abuse Research Center, it was found that ten percent of college students tend to use stimulants on an illegal basis at some point in their college years.

From News-Medical.Net:

“Most students who use their friend’s stimulants do it to improve performance,” said Scott Teitelbaum, M.D., medical director of the Florida Recovery Center at UF. “It’s like athletes taking steroids – the idea that you can study better, harder, longer, as if you were hitting a ball farther.”

But the pills won’t make up for a semester of slacking off, said Teitelbaum.

“When you look at the students that use illicit (stimulants), their performance at school is worse,” Teitelbaum said. “And that’s probably because the need to use the drug reflects them being behind, and needing to cram and catch up.”

Ritalin revs up the central nervous system, creating feelings of alertness that fall somewhere between those produced by caffeine and cocaine.

“If you look at Ritalin structurally, it’s the closest relative to cocaine,” said Teitelbaum. “I think it depends on the dose one is taking, and why they’re taking it. Some people take stimulants solely for the effect on concentration. Other people are taking it for the buzz.”

Pharmaceutical abuse is on the rise among teens, surpassing the combined rates of crack/cocaine, Ecstasy, heroin and methamphetamine abuse, according to the Partnership for a Drug-Free America. Experts predict the trend will continue because the pills are inexpensive and widely available.

“Unlike cocaine, you can get Ritalin very cheaply from your friends because all they need is their co-pay,” Teitelbaum said. “There’s a great availability.”

From the above conclusions, it can be easily found out that usage of illicit drugs is still on a rampant rise despite the United States government trying its best to eradicate drugs.

Wednesday 26, Aug 2009

Effective treatment of steroid-naive ulcerative colitis patients

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Effective treatment of steroid-naive ulcerative colitis patientsAccording to a research article published in the World Journal of Gastroenterology, the therapeutic utility of LCAP (Leukocytapheresis) for steroid-naïve patient with UC was investigated by Dr. Masatoshi Kudo from Kinki University School of Medicine of Japan. Kudo remarked that the efficacy of LCAP can be forecasted on the assumption of endoscopic findings.

It was found that steroid administration can lead to varying side effects despite the fact that it is considered as a second-line therapy for the induction of remission in ulcerative colitis (UC), if remissions are not attainable by salazosulfapyridine or mesalazine treatment.

From Eurekalert.org:

In 1995, LCAP was introduced for patients with UC. LCAP is a method where the blood is passed though a leukocyte removal filter before being returned to the body. On average, 1.6 × 1010 leukocytes are removed during one session. These leukocytes include granulocytes, lymphocytes and monocytes. Almost 100% of granulocytes and monocytes and 60% of lymphocytes are removed by removal filter. In this study, we found 61.1% of steroid-naive UC patients (11/18) had entered remission eight weeks after the last LCAP session.

Since steroids can induce remission in 45% to 90% of salazosulfapyridine or mesalazine non-responders, it appears that LCAP is as efficacious as steroids as a second-line treatment. Analysis of the endoscopic findings of the patients revealed that while the remission rate of the patients with erosion was extremely high after LCAP; however, that of the patients with geographic ulcers and deep ulcers extremely low. None of the patients experienced any severe adverse effects from LCAP. Given the low rate of adverse events suffered by patients treated with LCAP, we propose that patients with moderately active UC should be treated with LCAP before steroids are considered.

It can thus be concluded that LCAP may prove to be an effective and safe treatment option for steroid-naive UC patients with moderate activity. In addition to that, endoscopic findings are beneficial for predicting the treatment efficacy.

Tuesday 25, Aug 2009

Acute sinusitis can be prevented with steroids

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Acute sinusitis can be prevented with steroidsAccording to a new review by researchers from Israel, steroid nasal sprays – either alone or with antibiotic therapy – can prove to be effective in preventing and curing acute sinusitis, which can develop following a chest cold.

The review was published in an issue of The Cochrane Library, a renowned publication of The Cochrane Collaboration, which is an international organization evaluating all aspects of health care.

It is believed that approximately 37 million Americans suffer from acute sinusitis. The findings of this review will help them and patients worldwide to get relief.

From News-Medical.Net:

Study participants, who underwent X-rays or nasal endoscopy to confirm diagnosis, received either a placebo or intranasal corticosteroids for two or three weeks, alone or in combination with antibiotics. Intranasal corticosteroids used included fluticasone propionate (Flonase), mometasone furoate (Nasonex) and budesonide (Rhinocort).

Overall, 73 percent of the patients treated with nasal steroids experienced relief or marked improvement of symptoms during the study period, compared with only 66.4 percent of patients who received the placebo.

“For every 100 patients treated with intranasal corticosteroids, seven additional patients had complete or marked symptom relief,” compared to those in the placebo group, the reviewers found.

Researchers pooled data from three of the four studies, excluding the lowest-quality study from the statistical analysis.

None of the studies reported serious side effects, and rates of sinusitis relapse were similar between the treatment and placebo groups.

Stronger doses of nasal steroids appeared to work better. Patients receiving daily doses of 400 micrograms were more likely to experience relief of sinusitis symptoms, than were patients receiving 200-microgram doses.

Allen Seiden, M.D., director of the University of Cincinnati Taste and Smell Center, remarked that more data is required before recommendations for intranasal corticosteroids can be made.

The involved reviewers were of the view that the findings of this review support the clinical rationale behind addition of an intranasal corticosteroid to antibiotic therapy.

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