According to new bench research from the Mayo Clinic, female sex hormones could work with beta-agonists in minimizing airway constriction.

Lead student researcher, Elizabeth A. Townsend, of the Mayo Clinic Department of Physiology and Biomedical Engineering, said that it will be of interest to ascertain whether sex steroids such as estrogen and progesterone play a role in modulation of airway tone.

From Sciencedaily.com:

Townsend and colleagues then asked whether estrogens could produce bronchodilation, and might the combination of commonly used bronchodilators (beta-2 agonists) and estrogens be used to produce even greater bronchodilation? In laboratory studies using human airway smooth muscle cells, they found that combined treatment with estradiol and the beta-agonist, isoproterenol (which non-selectively activates both beta-1 and beta-2 adrenergic receptors), had a synergistic effect on decreasing intracellular calcium and force more than either estradiol or isoproterenol alone. They also found that these effects may involve a common signaling pathway.

“These novel data suggest that estradiol has bronchodilatory properties, and may potentiate beta-2-agonist effects,” said Ms. Townsend. “The finding that estrogens interact synergistically with beta-adrenoceptor signaling (perhaps using common pathways) to facilitate bronchodilation was exciting, and lends itself to further studies on interactions between sex steroids and beta-2-agonists.” But she and her team also cautioned that there is still considerable research necessary to fully understand the association between sex steroids and factors that contribute to asthma, before the information can be used clinically in patients to relieve asthma symptoms.

The findings are being presented at the ATS 2010 International Conference in New Orleans.

Tags: Estrogen, estrogens, progesterone, sex steroids, steroids

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