A single protein in a combination with a related protein can play a pivotal role in the complex journey of the body to obesity, as per Dr. Ronald M. Evans, a Howard Hughes Medical Investigator at The Salk Institute’s Gene Expression Laboratory.

Evans further remarked that this study can provide the latest, specific approach to cure obesity related ailments such as atherosclerosis, hyperlipidemiama, and resistance to insulin.

From News-Bio-Medicine.Org:

Dr. Ronald M. Evans, a Howard Hughes Medical Investigator at The Salk Institute’s Gene Expression Laboratory, presented two new studies (date) at Experimental Biology 2005 in the scientific sessions of the American Society for Biochemistry and Molecular Biology. The studies focus on genes for two of the nuclear hormone receptors that control broad aspects of body physiology, including serving as molecular sensors for numerous fat soluble hormones, Vitamins A and D, and dietary lipids.

The first study focuses on the gene for PPARd, a master regulator that controls the ability of cells to burn fat. When the “delta switch” is turned on in adipose tissue, local metabolism is activated resulting in increased calorie burning.

Increasing PPARd activity in muscle produces the “marathon mouse,” characterized by super-ability for long distance running. Marathon mice contain altered muscle composition, which doubles its physical endurance, enabling it to run an hour longer than a normal mouse. Marathon mice contain increased levels of slow twitch (type I) muscle fiber, which confers innate resistance to weight gain, even in the absence of exercise.

Dr. Evans pointed out that PPARd (Peroxisome proliferator-activated receptor delta) which acts as a master regulator in controlling ability of the body cells to burn fat, can suppress artery’s inflammatory response with an aim to dramatically slowdown progression of the lesion. The study revealed that the PPARd drugs can prove to be effective in inhibiting atherosclerosis by limiting the level of inflammation besides enhancing physical performance.

Tags: atherosclerosis, hyperlipidemiama, nuclear hormone receptors, obesity, peroxisome proliferator-activated receptor delta, PPARd, PPARd drugs, steroid receptor

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