An Australian study stated that low sexual function in women can’t be diagnosed just by looking at the level of circulating sex hormones such as testosterone. According to Dr. Susan Davis, there are no clinically significant relationships between low scores on a psychometric test of sexual function and serum total testosterone, serum free testosterone, or androstenedione.

The only link that researchers found was between low sexual function and low levels of the androgen precursor dehydroepiandrosterone sulfate (DHEAS), but this is not useful diagnostically. This is because although women who self-reported sexual dysfunction had low DHEAS, most women with low DHEAS had normal sexual function.

From Medpage today:

Dr. Davis and colleagues recruited 1,423 women, whose names were found through the electoral rolls in Victoria between April 2002 and August 2003.

The women were asked to take the Profile of Female Sexual Function (PFSF), which measures low sexual desire and related symptoms, grouped into seven domains — desire, arousal, orgasm, pleasure, sexual concerns, responsiveness, and self-image.

On the same day they filled out the PFSF, the women were asked to provide a fasting blood sample, which was analyzed for sex steroids.

On the other hand, for women ages 45 to 75 years, reported low levels of arousal, responsiveness, and pleasure were significantly associated with low levels of DHEAS. For younger women, the only significant association was to responsiveness.

However, most women with low levels of DHEAS -– defined as less than 773.8 ng/ml -– did not report sexual dysfunction, the study showed.

Researchers claimed that much of the androgen function in the body takes place within cells; circulating androgens, such as serum testosterone, may be a poor marker for what happens within tissues. They suggest that sex steroids influence female sexual function, but there is no serum androgen level that defines female androgen insufficiency.

Tags: Androgen, DHEAS, Dr. Susan Davis, testosterone

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