Budesonide found to reduce symptoms of chronic rhinosinusitisBudesonide, a form of corticosteroid, used in asthma and nasal polyps, has been found to be effective in treating symptoms of chronic rhinosinusitis.

Rhinosinusitis is a new classification of sinusitis referring to the inflammation of the sinuses including the nose. A sinusitis is considered chronic if it persists for 12 weeks or more. It may occur with nasal polyps but there are cases without.

According to Neil Sachnadani, BS, and colleagues at the Washington University School of Medicine in St. Louis, a nasal wash containing budesonide and saline solution can improve clinical symptoms of rhinosinusitis.

The study was conducted by giving the participants a nasal wash with 0.25 mg budesonide in 5 ml saline solution. The participants have to apply the nasal wash in each nostril for 30 days. They were also made to answer a set of questionnaires relating to their symptoms and related quality of life. This was done before and after the study period.

A standard method of testing used was consyntropin injections. It stimulates the release of cortisol by the adrenal glands. This is to determine the adrenal response after budesonide therapy.

All participants reported some form of relief after therapy. Researchers also found that adrenal responses remained normal even after budesonide therapy. This indicates that budesonide is effective in treating rhinosinusitis without suppressing the adrenal function of the body.

From Eurekalert:

A nasal wash containing the corticosteroid budesonide appears to reduce symptoms of chronic rhinosinusitis without suppressing the function of the adrenal glands, a known complication of this type of drug that would indicate absorption throughout the whole body, according to a report in the March issue of Archives of Otolaryngology–Head & Neck Surgery, one of the JAMA/Archives journals.


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