A trainer who admitted previously of supplying steroids to John Canseco recently remarked that he also supplied performance enhancing drugs to Mark McGwire.

Curtis Wenzlaff, the trainer who was arrested for steroids distribution in 1992, told ESPN’s “Outside the Lines” that McGwire wanted to get “bigger, faster, stronger”.

From Sportsillustrated.cnn.com:

McGwire last week admitted for the first time that he used steroids and human growth hormone on and off for a decade, including when he set the season home run record with 70 in 1998. He said he took performance-enhancing drugs for health, not for strength.

“There are other things you can take for health that are anabolic, but it wouldn’t be that type of combination,” Wenzlaff said. “If Paris Hilton were to take that array, she could run over Dick Butkus.”

McGwire, who retired as a player after the 2001 season, was hired in October as hitting coach of the St. Louis Cardinals.

Fans of McGwire are just hoping that he is spared to be left alone to do what he does best, getting involved with baseball.

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Marion Jones, the disgraced Olympic Sprinter and once known as the fastest woman in the world, was recently introduced as the member of WNBA’s Tulsa Shock.

Jones offered no apologies for use of steroids or her time in the Federal Prison and didn’t seem reluctant to answer questions about her troubled past.

Jones said at a news conference, flanked by team president Steve Swetoha and Coach Nolan Richardson, that redemption is not a word in her vocabulary.

From Sportsillustrated.CNN.com:

Jones also spent about six months in a Texas prison for lying to federal prosecutors about doping and her role in a check-fraud scam.

The 34-year-old Jones joined the team just four days after working out for Richardson, who is also the team’s general manager. She was signed to at least a one-year contract but terms were not disclosed.

Jones was the starting point guard on North Carolina’s national championship team in 1994 and she was drafted by Phoenix in 2003 but never played in the WNBA. She said playing for the Shock is not about her past but instead fulfills her dream of playing basketball against the best players in the world.

“I think when I even started to think about this 10 months ago, I know how much the game has grown from the time that I played,” Jones said. “And that became even more of a challenge for me, because I know that although I know certain things and played a certain way, that it’s 10 times faster, that the athletes are 10 times more skilled.”

WNBA president Donna Orender, who attended the news conference, said Jones generates interest in the league because she’s a highly accomplished athlete who has competed on a global stage.

Steve Swetoha remarked that Jones may have harmed her career by making some ill-advised decisions but she deserves a chance to excel like every one.

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Juan Dixon, a former NBA player, was recently reported of being coming positive for the steroid nandrolone as per announcement from his Spanish team Unicaja.

Dixon gave the drug test in November before joining Unicaja. He was informed about the drug result and was handed over a suspension by the International Basketball Federation until further notice.

From Sportsillustrated.cnn.com:

The player gave the drug test in Greece in November, before he joined the Malaga-based team, Unicaja said on its Web site.

Dixon was informed of the positive result several days ago and the International Basketball Federation decided to suspend him on Friday. His suspension is indefinite until further notice.

Dixon, who won an NCAA championship with Maryland in 2002, played for Washington, Portland, Toronto and Detroit in the NBA.

The often untold relationship between steroids and sports is yet again highlighted and reaffirmed by this incident of steroid use.

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Jared Lovett, the South African Boxer, who recently lost on points to Thomas Oosthuizen during the IBO Light Heavyweight Youth Belt, has been banned for a period of two years.

This ban was imposed after Jared was found positive for using Stanozolol, a steroid. The ban will lasts until July 2011.

From Sportsillustrated.CNN.com:

Lovett tested positive for the anabolic steroid stanozolol on July 11 after his loss on points to Thomas Oosthuizen in a bout for the IBO Light Heavyweight Youth Belt.

The South African Institute for Drug-Free Sport held a hearing on the case last month and announced Lovett’s two-year ban on Thursday.

The ban lasts until July 2011.

The 23-year-old Lovett, nicknamed “The Storm”, told South African newspaper The Sowetan on Friday that he will take the punishment “on the chin.”

Once again, the continuing relationship between steroids and sports has been highlighted by this news of Jared getting caught for use of steroids.

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The trend of big names in baseball getting accused for use of steroids is continuing with Sammy Sosa being the new name. The baseball slugger was identified by the New York Times as having tested positive for a performance-enhancing drug in 2003.

This continuing trend is bothering sports officials and fans equally and there could be just hopes that this long-staged drama ends soon.

From Sportsillustrated.CNN.com:

Sosa’s entry into the Hall of Fame was very much in doubt even before Tuesday. The weight of circumstantial evidence and buzzing among baseball people in and out of uniform always did engender heavy suspicion, even before his 2005 demureness in front of Congress. Naivete would be in order to think someone who corked bats and competed passionately for individual records and glory against Barry Bonds and McGwire in an age with no enforceable drug rules in place would draw a self-imposed line at using steroids — just as his body transformed into a hunk of musculature.

At the age of 28, Sosa was a career .257 hitter who slugged .469 and who hit one home run every 19.4 at-bats. He was a decent enough player. But over the next six years — from 1998 through 2003, the last year you could juice without penalty — Sosa hit .302, slugged .635 and hit one home run every 10.6 at-bats. He hit more home runs in those half dozen years than Hank Greenberg, Gary Carter or George Brett hit in their entire careers. He became one of the all-time greatest sluggers ever, or so we were led to believe.

To the baseball fans and community, the news of Sammy Sosa getting involved with steroids is not a shocker to say in the real sense as many other eminent names have already fallen and identified in the trap of steroids.

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Obese people are at a higher risk of developing persistent or severe persistent asthma than their thinner counterparts, as per a study presented at the American Thoracic Society 2007 International Conference.

During a study involved 3,059 adults with asthma, it was noted that obese patients (BMI=30) were more likely to report having continuous symptoms, miss more days of work, make more ER visits, and make more use of inhaled steroids for asthma control.

From News-Medical.Net:

The studies that have been done have been small, but this study took data from the National Asthma Survey, which includes 5,741 asthmatics, Dr. Taylor notes. “We had enough data to adjust for other factors, such as gender, race, income and employment status, and ensure that these factors were not playing a role in the results. Even after taking these variables into account, the association between obesity and asthma severity still held.”

Dr. Taylor notes that this study, like many previous studies, shows the link between asthma and obesity is more prominent in women. “A big part of that is simply that 70% of the study subjects were women,” he says. “We did find a statistically significant association between obesity and asthma severity in men, too.”

While it’s not known for sure how asthma and obesity are linked, Dr. Taylor notes that one potential mechanism seems to be an association between the hormone leptin, which is produced by fat cells and plays a role in body weight regulation, and inflammation of airways seen in asthma. Obesity also may impact the lungs in other ways to increase the risk of asthma.

Lead researcher Brian Taylor, M.D., of Emory Crawford Long Hospital in Atlanta, said that there has been little data on obesity and asthma severity in the past despite a number of studies on obesity and asthma prevalence.

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Scientists from the University of Michigan have reported that a compound called benzodiazepine-423 (Bz-423) suppresses growth of cells in a model of psoriasis.

This study available online in the Journal of Pharmacology and Experimental Therapeutics suggested that Bz-423, which is known to minimize harmful side effects of the autoimmune disease lupus, can also be effective in treating psoriasis.

From News-Medical.Net:

“Currently, the best treatments for skin lesions associated with psoriasis are topical steroids, but the problem with those drugs is that they’re not selective for the disease-causing cells. They affect normal cells as well, and repeated use over time can lead to tissue destruction,” said Gary Glick, who is the Werner E. Bachmann Collegiate Professor of Chemistry and a professor of biological chemistry in the U-M Medical School. “There are also protein drugs approved for use in treating psoriasis, but those drugs are injected instead of applied topically, which makes them more costly, less convenient and more likely to cause side effects since they are delivered throughout the body.”

“What makes our compound particularly exciting is that it has the potential to be applied topically, and it shows very good selectivity for models of the disease-causing cells versus normal cells,” Glick said. “So we believe the problems associated with repeated topical steroid use could possibly be alleviated with compounds like this.”

This study was led by Gary Glick, who is the Werner E. Bachmann Collegiate Professor of Chemistry and a professor of biological chemistry in the U-M Medical School. Glick’s coauthors on the paper were James Varani, professor of pathology; Narasimharao Bhagavathula, a research investigator in the pathology department; Hilary Scherzer and Kevin Fay, research associates in pathology; Kent Johnson, professor of pathology; Sewon Kang, professor of dermatology; and Anthony Opipari, assistant professor of obstetrics and gynecology.

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According to a research published in an issue of the British Journal of Clinical Pharmacology, forty percent of community pharmacists do not tell parents that they are dispensing off-label drugs to their children. Only 66 percent of the pharmacists felt that they had a responsibility to communicate about use of off-label drugs to parents.

This finding was disclosed in a research carried out by the Department of Medicine and Therapeutics at the University of Aberdeen, UK and involved 500 community pharmacists.

From News-Medical.Net:

“Community pharmacists in the UK are responsible for overseeing the supply of prescription and over-the-counter medicine for use by children and ensuring that any off-label drugs are prescribed and dispensed appropriately.

“Give their role, we feel that greater emphasis should be placed on providing them with both undergraduate and postgraduate education in off-label dispensing, together with evidence-based information and training.”

More than 60 per cent of the community pharmacists surveyed said that they had been asked by a member of the public to sell over-the-counter medicines, such as antihistamines, analgesics and steroids, for off-label use in children.

Nearly all the respondents said that they used general drug guidelines or the pack insert to decide whether to dispense the drug, rather than specialist formularies or guidelines on dispensing to children.

“Despite the wide availability of specialised resources, such as Medicine for Children, published by the Royal College of Paediatricians, only one respondent said they used them, says Dr McLay.

Co-author Dr James McLay said that community pharmacists who responded to the questionnaire were aware of the issues surrounding off-label drug distribution to children.

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The US Food and Drug Administration (FDA) has authorized a clinical study with recombinant human C1 inhibitor (rhC1INH) for treating antibody-mediated rejection (AMR) in kidney transplantation, as per Biotech company Pharming Group NV.

A clinical trial with rhC1INH under an Investigator IND from the FDA is expected to be conducted by Dr. Hans Sollinger of the University of Wisconsin, Madison.

It is important to note here that more than 15,000 kidney transplants happen in the United States on an annual basis and the organ transplant program at University of Wisconsin was ranked first in the USA in 2005 and 2006 for numbers of kidney transplants performed.

From News-Medical.Net:

Recombinant human C1 inhibitor is a key inhibitor of the classical complement system. In the planned study, rhC1INH will be evaluated in patients with AMR for its ability to prevent the inflammatory damage seen in the kidney, improve organ function, and reduce the likelihood of graft loss. In this study, Dr. Sollinger will study patients with AMR to compare rhC1INH against standard of care, which consists of a combination of non-specific treatments including plasmapheresis, steroids and intravenous immunoglobulin. Previously, Pharming successfully completed a Phase I safety study with rhC1INH in healthy volunteers.

Dr. Hans Sollinger, University of Wisconsin commented: “I am enthusiastic about taking rhC1INH forward in this clinical trial for antibody-mediated rejection. Antibody-mediated rejection is a serious and costly complication for which there is no specific therapy. RhC1INH has great potential in changing the way we treat AMR and extend the life of a transplanted kidney.”

Dr. Bruno Giannetti, COO of Pharming remarked that he is excited to see how rhC1INH may help in transplantation as well as other complement-mediated diseases.

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According to a study by researchers from the UT Southwestern Medical Center, steroids can easily facilitate the recovery process for patients affected by pneumonia and even better than use of antibiotics alone.

It was suggested by the study that health of an affected patients can be restored back when steroids and antibiotics are combined.

From News-medical.net:

Adding corticosteroids to traditional antimicrobial therapy might help people with pneumonia recover more quickly than with antibiotics alone, UT Southwestern Medical Center scientists have found.

Unlike the anabolic steroids used to bulk up muscle, corticosteroids are often used to treat inflammation related to infectious diseases, such as bacterial meningitis. Used against other infectious diseases, however, steroid therapy has been shown to be ineffective or even harmful.

In a study available online and in a future issue of the Journal of Infectious Diseases, researchers at UT Southwestern show that mice infected with a type of severe bacterial pneumonia and subsequently treated with steroids and antibiotics recovered faster and had far less inflammation in their lungs than mice treated with antibiotics alone.

Dr. Robert Hardy, Study’s Senior Author & Associate Professor of Internal Medicine and Pediatrics, said that clinic trial would soon be performed for confirm the finding. It is worth noting that a combination of steroids and antibiotics can provide relief to a patient in the midst of an asthma attack (M pneumoniae infection).

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