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Estrogen can minimize stroke damage by inhibiting protein

Estrogen can minimize stroke damage by inhibiting protein According to researchers at the Medical College of Georgia, estrogen can inhibit stroke damage by inactivating p53 (a tumor-suppressing protein) that is known to inhibit many forms of cancer.

Limor Raz, a fourth-year Ph.D. student in the MCG School of Graduate Studies, remarked that the research suggests that estrogen is capable of suppressing p53 after stroke and thus inhibit the damage.

From Sciencedaily.com:

Ms. Raz found that estrogen can chemically alter p53 and attenuate the cascade, thus leading to reduced stroke damage.

She has been working with Dr. Darrell Brann, chief of developmental neurobiology and associate director of the MCG Institute of Molecular Medicine and Genetics, and will present her findings today in Colorado at the American Physiological Society conference focusing on the cardiovascular effects of sex steroids and gender.

Global cerebral ischemia, the most common type of ischemic stroke, in which blood flow to the brain is disrupted, was induced, damaging primarily the hippocampal CA1 region of the brain. In this study, a group of female rats were treated with estrogen versus placebo for seven days and estrogen’s effect on p53 signaling was examined.

P53, the protein in the mitochondria, is considered to be the guardian of the genome due to the fact that it regulates the cell cycle besides preventing genome mutation.