Belonging to the category of GH secretagogues, GHRP-6 or growth hormone releasing peptide-6 is a synthetic hexapeptide that is admired for stimulating the release of growth hormone (GH) by two completely different mechanisms. While growth hormone releasing peptide-6, on one hand, amplifies the natural GHRH signal transduction pathway, it also acts as a functional antagonist of the hormone to inhibit somatostain (GH secretion).

One of the biggest reasons behind the popularity of GHRP-6 is that it has positive effects on growth hormone release and its use is closely associated with the promotion of food intake by increasing hunger. Moreover, the synthetic hexapeptide is also helpful to aid metabolism and medically recommended to help patients suffering with complications such as growth hormone deficiency, eating disorders, obesity, and cachexia.

It is also useful in promoting muscle mass and strength enhancements besides leading to loss of body fat and weight besides promoting the rejuvenation and strengthening of joints, bone mass, and connective tissue. GHRP-6 may be used for re-stimulating the natural production of growth hormone, when the natural GH secretion has been inhibited by long-term synthetic usage, as it has a direct effect on the feedback loop that signals growth hormone release inhibition. In addition to all these advantages, GHRP-6 is also useful in promoting the sense of well being, healing of joints and tendons, and improving the natural production of growth hormone, besides increasing normal pulsatile physiological secretion level by its hypothalamic action and pulsatile secretory bursts of GH.

The recommended dosage of GHRP-6 is 400-600 mcg administered via subcutaneous method, divided in 2-3 injections and it must be kept at a controlled room temperature of 25°C (77°F) with excursions permitted up to 15-30°C (59-86°F) to maintain its shelf life.