Glucocorticoids Trigger Diabetes And HypertensionSteroids called glucocorticoids are critical for treating diseases such as asthma, arthritis and pain syndromes, but they also can trigger diabetes and hypertension. In order to show why these drug exhibit such adverse reactions, a team from the Washington University School of Medicine in St. Louis conducted a study.

In the study, the researchers found out that a protein called peroxisome proliferator-activated receptor-alpha (PPAR-alpha) is activated by fatty acids and appears to be important in the development of these problems. This helps explain the high incidence of diabetes and hypertension in obese individuals who have more glucocorticoids than average weight individuals.

The researchers believed that hypertension and diabetes happen to overweight people who also produce significantly higher glucocorticoids. So, if the person has excess glucocorticoids or if he is using this medication, he has greater risk of developing hypertension and diabetes.