Pamela Fraker, MSU Professor of Biochemistry and Molecular Biology and a lead scientist, said that the neuro-endocrine system plays a big role in the human immune system and body overweight.

A number of factors such as poor diet, certain steroids, chronic stress do affect the immune system of the body.

Researchers studied the relationship between metabolism, the immune system and the neuro-endocrine systems. The study showed that the leptin, which is the hormone secreted by fat cells, administered the effect of white blood cell production in the body, enhancing body’s immune function.

From Brightsurf:

Scientists know that a number of factors can affect the body’s immune system: poor diet, certain steroids, chronic stress. Now researchers at Michigan State University have discovered that an appetite-controlling hormone also affects the immune system, while natural versions of certain steroids do not.

“Many investigators have been trying to unlock the key to obesity for years,” said Fraker. “The more fat a person has, the more leptin there is in the bloodstream. In obese people, it seems that the body becomes leptin-resistant — the signals get jammed. So giving obese people leptin doesn’t help them lose weight.”

MSU scientists further demonstrated the effect of leptin on immune system by working on mice. This effect was genetically programmed to have non-functional leptin. One of the mice groups was genetically programmed under this study to have non-functional leptin receptors. It was seen that mice that were given leptin had witnessed double the number of B cells, a type of white blood cells produced in the bone marrow that fights infection by making antibodies.

Fraker and his team is further investigating on the fact that that the steroids may help even obese people to increase their immunity. The studies may be released soon and so do the effect of steroids on immune system.

Tags: antibodies, immune system, leptin, metabolism, neuro-endocrine system, obesity

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