As per a randomized clinical trial for patients with newly diagnosed multiple myeloma, low doses of the steroid, dexamethasone, along with lenalidomide can help in prolonging survival for multiple myeloma patients.

The trial was conducted by a network of researchers led by the Eastern Cooperative Oncology Group (ECOG) and sponsored by the National Cancer Institute (NCI).

It was revealed during the trial that a combination of dexamethasone (low dosages) and lenalidomide is far effective than lenalidomide and higher doses of dexamethasone.

As per noted study chair Vincent Rajkumar, M.D., Mayo Clinic, Rochester, Minn, these results are expected to have major implications for therapy relevant to multiple myeloma, a cancer typically found in bone marrow.

From Bio-Medicine.Org:

Preliminary results from a large, randomized clinical trial for patients with newly diagnosed multiple myeloma, a cancer typically found in bone marrow, has shown that the use of a low dose of the steroid dexamethasone (Decadron ®), in combination with lenalidomide (Revlimid ®) is associated with improved survival when compared to a treatment regimen with lenalidomide and a higher, standard dose of dexamethasone. The clinical trial was sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and conducted by a network of researchers led by the Eastern Cooperative Oncology Group (ECOG).

The data monitoring committee overseeing the trial (known as E4A03) recommended that the survival results from a recent interim analysis be made public because of early differences being seen in overall survival rates. Researchers found that patients in the study who received low-dose dexamethasone and lenalidomide had a one-year survival of 96 percent compared to 86 percent for patients treated with the standard-dose of dexamethasone and lenalidomide. In addition, there were fewer side effects associated with the low-dose dexamethasone and lenalidomide.

Rajkumar remarked that the results of this trial are very positive and can be seen as a potential real step ahead in the treatment of multiple myeloma.

Tags: dexamethasone, lenalidomide, multiple myeloma

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