Minimizing eosinophilic airway inflammation in severe asthmaA high dosage of extra intramuscular corticosteroids can result in almost-complete disappearance of eosinophilic cells leading to reduced use of “rescue” medications apart from facilitating improvements in lung function tests of patients. This finding was revealed by investigators during a study of patients with severe asthma having eosinophils in their sputum despite extensive antiasthma medication.

Eosinophils are a type of white blood cell that constitute around 1-3 percent of the total white cell count in the body. When infectious cells or foreign substances enter the body, lymphocytes and neutrophils attract eosinophils that release toxic substances to destroy abnormal cells.

From News-Medical.Net:

Writing in the second issue for September 2004 of the American Thoracic Society’s peer-reviewed American Journal of Respiratory and Critical Care Medicine, Elisabeth H. Bel, M.D., Ph.D., of the Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands, along with four associates, studied 22 non-smoking outpatients with severe asthma in order to prove that patients with extensive eosinophilia, despite significant anti-inflammatory treatment, were sensitive to high dose injected corticosteroids. Of the 22 patients in the study, 11 received the steroids and 11 were given placebo over a 3-week period. All patients had sputum eosinophilia above the upper limit of normal. However, after treatment with the injected corticosteroids, sputum eosinophils returned to normal levels (from zero to 2 percent) in the 11 treated patients.

The authors note that injected corticosteroids can reach the region of bone marrow besides minimizing eosinophils being produced by processes involving inflamed tissue.


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