The level of nitric oxide in the exhaled breath of a patient suffering from asthma can portent worsening of asthma symptoms, according to results reported in the second issue for January of the American Journal of Respiratory and Critical Care Medicine, a publication of the American Thoracic Society.

The study also revealed that such a complicated situation may highlight an imminent attack, which can get linked with inflammation concerning underlying airway.

From News-Medical.Net:

Johan C. de Jongste, M.D., Ph.D., at the Erasmus University Medical Center-Sophia Children’s Hospital in the Netherlands, and colleagues randomized 151 children from 15 academic centers and hospitals with mild to moderate asthma to a 30-week monitoring course. Families were called every three weeks and reported on the daily symptoms in the prior three weeks. The child’s medication was adjusted accordingly.

The researchers compared the rates of exacerbation, symptoms, use of medications and other endpoints between the last 12 weeks in the two groups. There were no significant differences whether or not FENO had been part of the daily monitoring. However, both groups enjoyed an impressive overall improvement in symptoms, despite a reduction of about 50 percent in inhaled steroid dose, suggesting considerable benefit of frequent monitoring.

“We speculate that daily supervision and frequent phone contacts have produced an improvement that could not be beaten by additional monitoring of FENO, most likely because of a ceiling effect on compliance,” wrote Dr. de Jongste.

It is considered that findings of this study have made the monitoring of nitric oxide of significant interest, especially in children, by evaluating it as a potential way for providing help to clinicians for improving treatment results.

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