Researchers at the University of Bristol are looking for volunteers to find out if hydrocortisone, a drug affecting stress system of the body, could help people with depression and not responding to present forms of treatment.

It is believed that Severe or recurrent depression affects 3-5 percent of the population and 10-30 percent of this population do not respond to the present-day treatment options.

From News-Medical.Net:

Evidence from UK and US studies suggests that a short course of steroids, such as hydrocortisone, may be sufficient to trigger a beneficial response in people who have TRD who are on ‘standard’ antidepressant treatment.  If this were to be confirmed, it would be a significant advance as it may enable a restoration of response to conventional treatments in these individuals.  A further advantage is that such an intervention is inexpensive, relatively simple and could be carried out in outpatient or even appropriate primary care settings.

The researchers are looking for patients with depression who have failed to respond to two antidepressant medications and who would like to be assessed for entry into the study.

Dr Andrea Malizia leading the team of Bristol researchers has a long-standing clinical and research interest in treatment resistant depression and spearheads a specialist outpatient service at the Bristol Royal Infirmary.

Tags: depression, hydrocortisone, steroids

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