Corticosteroids have been hailed as powerful drugs for treating inflammatory conditions such as asthma. Although the anti-inflammatory drugs offer instant relief to the patients, they bring severe side effects.

But the hope of drugs without adverse side effects has been realized by a team spearheaded by Dr. Henry J. Lee who has led antedrug research in anti-inflammatory, anti-AIDS and anti-cancer drugs for nearly 30 years.

These drugs, known as antedrugs, have been developed in a lab at Florida A&M’s College of Pharmacy.

From Sciencedaily.com:

Antedrug design is a new approach to create safer drugs that attack a problem such as inflammation then quickly become inactive before they can cause damage. The primary objective of this study was to synthesize a new group of corticosteroids that have anti-asthmatic and anti-inflammatory properties without adverse side effects.

The researchers synthesized new antedrugs, isoxazoline derivatives, from prednisolone. They then tested the derivatives in a test tube and found that antedrugs effectively reduced inflammation. In fact, they found isoxazoline derivatives were five times more potent than prednisolone in binding affinities to the cell corticosteroids receptors and reducing inflammation.

This study entitled as Anti-Inflammatory Activities of New Steroidal Antedrugs Isoxazoline Derivatives was conducted by Drs. Henry J. Lee, Younes J. Errahali, LeeShawn D. Thomas, Brenda G. Arnold and Glory B. Brown, all of the Florida Agricultural and Mechanical University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, Florida.

Tags: antedrugs, Asthma, corticosteroids, prednisolone

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