New approach for treating severe asthma identifiedAccording to a small study, a potential new treatment approach for treating severe asthma has been identified. This approach is aimed at blockage of a powerful immune system chemical that is present in large quantities in patients with severe form of asthma.

It is considered that one in every ten asthmatics suffers from the severe form of the disease that occasionally requires progressively higher doses of steroids in an attempt to control symptoms.

From News-Medical.Net:

Included in the study were 26 healthy people, 67 mild asthmatics, and 51 severe asthmatics. Bronchial fluid and lung tissue samples were taken from the participants to discover their levels of TNF alpha.

Levels were significantly higher in those with severe disease and concentrated in one particular type of immune cell (mast cells) which are recognised components of the inflammatory reaction in asthma.

TNF alpha levels were low and similar in those with no asthma or who only had mild symptoms.

This suggests that the high levels of TNF alpha in severe disease are characteristic of more chronic disease that is resistant to steroid treatment, rather than a feature of the disease itself, say the authors.

The authors caution that further research is required before this approach can be recommended at any stage but that does not mean, in any way, that this approach is not a potentially new avenue of treatment for severe asthma.


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