New research on use of chronic corticosteroids According to experts at the annual meeting of the American College of Allergy, Asthma and Immunology (ACAAI) in Seattle, there is an unexpected impact on human bones due to chronic corticosteroid use.

Rebecca Green, M.D., Ph.D., assistant professor, pediatric endocrinology and diabetes, Washington University School of Medicine in St. Louis, Mo., remarked that corticosteroids have been used in controlling many symptoms for ailments where all previous treatment options have failed to deliver. But it was also remarked that side effects are very much possible with high doses of corticosteroids.

From News-Medical.Net:

Inhaled corticosteroids are one of the most effective medications for controlling asthma. These anti-inflammatory medications reduce swelling in the airways, improve lung function and act to prevent asthma episodes or “asthma attacks“. Intervention with inhaled corticosteroids can improve asthma control and reduce emergency department visits, hospitalization and deaths.

The side effects attributed to corticosteroids include decreased bone mineral density and reduced bone mass, and also in children, reduced growth rate. According to Dr. Green, strategies to alleviate these effects include minimizing oral doses and adding topical or inhaled steroids to provide the same anti-inflammatory benefit in the areas affected by inflammation while avoiding systemic effects. Disturbance in bone acquisition in childhood can reduce peak bone mass and therefore significantly impact the life time risk of osteoporosis.

“One of the challenges has been distinguishing the effects of the inflammatory process itself on bone mass and growth, and the effects of corticosteroids on bone growth from the effects of corticosteroids on bone mass,” she said.

Dr. Kelly, professor emeritus of pediatrics, University of New Mexico Health Sciences Center, Albuquerque, N.M., said that the usage of inhaled corticosteroids has the potential for minimizing bone mineral growth in male children passing the stage of puberty but the involved risk is more than the ability to minimize the amount of oral corticosteroids used in these children.



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