According to researchers at the Johns Hopkins, a protein that is known to stimulate growth of blood vessel is responsible for the cell overgrowth in polyps’ development signifying one of the most severe forms of sinusitis.

It is considered by many scientists that this result finding will be more than helpful when it comes to developing novel therapies to treat this disease form that typically resists all current treatments.

From News-Medical.Net:

“This type of sinusitis isn’t subtle-you can spot the patients with polyps from across the room. They’re breathing through their mouths, they talk with nasal voices, they’re constantly sniffling, and their faces are swollen,” says Jean Kim, M.D., Ph.D., assistant professor in the Departments of Otolaryngology and Allergy and Clinical Immunology at the Johns Hopkins University School of Medicine, and a researcher at the Johns Hopkins Allergy and Asthma Center at the Johns Hopkins Bayview Medical Center.

Kim explains that surgery to remove the polyps is one of the most common treatments for this disease. However, nasal and sinus polyps in these patients almost always regrow. “Once the patient has entered the cycle of growing polyps, it’s very hard to get out,” she says. Another common treatment is oral steroids, but these drugs are fraught with many harmful side effects and also only temporarily treat the disease.

Chronic sinusitis is a common condition considered to affect approximately one out of every six people and can be classified as an ailment concerned with constant irritation and swelling of the nasal passages.

The findings suggest that medical practitioners could treat sinusitis in patients with polyps by making use of therapies that minimize VEGF (vascular endothelial growth factor) in sinus tissues.

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Tags: Chronic sinusitis, Oral Steroids, sinusitis, steroids, vascular endothelial growth factor, VEGF

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