According to an early study presented today at the annual meeting of the American Society for Bone and Mineral Research in Denver, an existing osteoporosis drug can regenerate some cartilage that was lost to osteoarthritis. While the study was on mice, the study model was able to closely mimic human osteoarthritis that develops post knee injuries as per authors of the concerned study.

It is medically proven that though presently-prescribed and used treatment options like steroids or non-steroidal anti-inflammatory agents may be effective for reducing pain but they do not seem to address the cartilage loss behind osteoarthritis that is expected to afflict more than 50 million Americans by 2020.

From News-Medical.Net:

The authors of the current study observed that chondrocytes within injured and degenerating cartilage have more PTH type 1 receptors on their surfaces. This makes them especially sensitive to the PTH signal that prevents harmful chondrocyte maturation into bone in the joint cartilage. Thus, PTH therapy should increase the cartilage supply exactly where cartilage loss is causing disease.

“Right now physicians have no way to bring back cartilage in patients who have lost it to osteoarthritis,” said Randy Rosier, M.D., Ph.D., professor within the Department of Orthopaedics and Rehabilitation at the University of Rochester Medical Center. “Our current results, at least in mice, show that we can inhibit cartilage degeneration and improve the volume of cartilage in diseased joints. It’s remarkable enough that this compound delays the loss of cartilage, but these results show it also may be able to restore, at least to some extent, cartilage in already degraded joint surfaces.”

Researchers examined the impact of a daily dose of Forteo-/teriparatide, manufactured by Eli Lilly, and a generic version of teriparatide made by Sigma on the progress of OA following injury in study mice.

It was remarked during the study that the pre-clinical findings offer strong proof-of-concept support for the prospective use of teriparatide to slow joint cartilage degeneration in OA patients, with even a possibility to reverse it.

Tags: cartilage loss, non-steroidal anti-inflammatory agents, osteoarthritis, osteoporosis, steroids, teriparatide

Posted in buy steroids, Steroid Cycles, steroid nation, Steroids and Anabolic Steroids