Scientists from the UT Southwestern Medical Center have found that adding corticosteroids to the traditional antimicrobial therapy may help pneumonia patients more than with antibiotics alone. Corticosteroids are generally used for treating inflammation in concern with infectious diseases while anabolic steroids are used for bulking up muscle.

Dr. Robert Hardy, associate professor of internal medicine and pediatrics and the study’s senior author, was of the view that there is no truth in the long held belief that steroids counteract the effect of the antibiotic.

From News-Medical.Net:

In the current study, mice infected with the M pneumoniae bacterium were treated daily with a placebo, an antibiotic, a steroid, or a combination of the antibiotic and steroid in order to investigate the effect on M pneumoniae-induced airway inflammation. The animals were then evaluated after one, three and six days of therapy.

“It turns out that the group that got both the antibiotic and the steroids did the best,” Dr. Hardy said. “The inflammation in their lungs got significantly better.”

Although antimicrobials remain the primary therapy for M pneumoniae infection, there have been several reports in recent years about physicians adding steroids to the treatment regimen of patients with severe cases, Dr. Hardy said. The problem, he said, is that those were individual case reports.

“They never had a control group, so it was impossible to tell what impact the addition of steroids had on recovery,” he said.

Other UT Southwestern researchers involved in the study besides Dr. Hardy were Dr. Christine Salvatore, infectious-disease fellow in pediatrics; Dr. Chonnamet Techasaensiri, postdoctoral trainee in pediatrics; Dr. Asunción Mejías, assistant professor of pediatrics; Dr. Juan Torres, visiting senior researcher in pediatrics; Kathy Katz, senior research associate in pediatrics; and Dr. Ana Maria Gomez, assistant professor of pathology, some researchers from the University of Milan also contributed to the study.

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