A potential breakthrough in the treatment of a rare but fatal medical condition affecting children and young people has been identified by researchers at the Queen Mary University London and the University of Leicester.

The preliminary data was published as a letter in the New England Journal of Medicine.

Dr Marcus Cooke, Senior lecturer in the Radiation and Oxidative Stress Section at the University of Leicester said that oxidative stress can make a great difference in the quality of an individual’s life.

From News-Medical.Net:

Dr Cooke said that idiopathic pulmonary haemosiderosis is a devastating condition. Characteristic of this condition is the accumulation of protein-bound iron in the lungs, a consequence of repeated bleeding in the lungs, coupled with inflammation and fibrosis. Ultimately this condition is usually fatal. Treatment to prevent the lung damage and prevent anaemia is a combination of corticosteroids and iron supplement.

Both chronic inflammation, and the presence of iron, released following bleeding into the lungs, can lead to a condition known as oxidative stress. Oxidative stress occurs when the production of free radicals, highly reactive chemicals, outweighs antioxidant defences. This leads to a great deal of damage to cells, and in particular DNA, the cell’s blueprint, and is likely to be responsible for the fibrosis, as the lungs try to repair the damage done by free radicals.

“In order to establish whether oxidative stress was indeed associated with episodes of bleeding into the lungs, we measured a biomarker of oxidative stress, and a marker of damage to DNA specifically, in urine.

Jonathan Grigg, Professor of Paediatric Respiratory and Environmental Medicine at Queen Mary University London, remarked that increased oxidative stress could be treated by making the use of antioxidant, N-acetyl cysteine – which has no side effects.

Tags: corticosteroids, idiopathic pulmonary haemosiderosis, iron supplement, oxidative stress

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