Chelsea Therapeutics, a pharmaceutical company specializing in treatment for RA and other immunological disease, has been putting efforts to develop an oral anti-inflammatory medication for treating patients suffering from rheumatoid arthritis (RA). The research is presently in Phase I clinical trials in the U.K.

This drug is expected to encourage women to treat their condition in a better way as it is less arduous than the presently recommended treatment options.

The potential therapy that is known as CH-1504 was initially developed by Dr. M. Gopal Nair, a professor and vice-chairman at the department of Biochemistry and Molecular Biology at the University of South Alabama.

From News-Medical.Net:

Current treatment options for RA include over-the-counter oral nonsteroidal anti-inflammatory drugs (NSAIDs) and other pain relievers; oral steroids; but the gold standard for treatment is still methotrexate, a drug that been used for nearly 30 years. Newly available compounds known as biologic response modifiers, such as etanercept and infliximab are used when the disease progresses (mostly in combination with methotrexate) but have to be injected and are very expensive.

While methotrexate is often effective, long-term chronic doses of the drug can be toxic to the liver, kidneys and other organs. Short-term tolerability issues such as nausea, vomiting and diarrhea also often limit its use.

“Given the problems that many patients have tolerating methotrexate along with its long-term safety concerns, a drug candidate that is proven to be as effective or more effective than with fewer side effects would be a major breakthrough in the treatment of RA. This may prompt patients to treat their condition earlier and continue treatment longer,” says Dr. Pedder.

According to Dr. Simon Pedder, CEO of Chelsea Therapeutics, drug candidates such as CH-1504 may help younger women to go for early treatment of RA and get benefited from effective management.

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