In another study related to steroids, Barts and The London School of Medicine and Dentistry stated that a common treatment used for wheezing in preschool children was ineffective. This new study, reported in the New England Journal of Medicine, bring national guidelines for the treatment of viral-induced wheezing under cirle of questions and doubts.

Wheezing caused due to viral infections in the upper respiratory tract is a common problem in preschool children, aged between ten months to six years. Usually they are treated with a short course of prednisolone, which is a steroid used for reducing inflammation in the airway and is prescribed in the treatments of allergic asthma attacks in older children and adults.

But, it has recently been recognised that wheezing in preschool children occurred due to viral colds and is a different condition from ‘allergic asthma‘. There is conflicting evidence whether a short course of oral prednisone is effective or not in this age group.

Professor Jonathan Grigg, a paediatrician at Barts and The London’s Institute of Cell and Molecular Science, along with other researchers studied a group of 700 children between the ages of 10 and 60 months, who were admitted to hospital with an attack of wheezing by viral infection. Half of them were treated with oral prednisolone and half with a placebo, and symptoms were monitored by health care professionals.

From Science Daily:

A new study from Barts and The London School of Medicine and Dentistry has found that a common treatment for wheezing in preschool children is no more effective than a placebo.

The findings, reported in the The New England Journal of Medicine, call into question national guidelines for the treatment of viral-induced wheezing.

Attacks of wheezing caused by viral infections in the upper respiratory tract are common in preschool children between the ages of ten months and six years. Preschool children who visit hospital with such symptoms are commonly treated with a short course of prednisolone - a steroid which is used to reduce inflammation in the airway and which is very effective in treating attacks of allergic asthma in older children and adults.

As result, the team did not found any significant difference in the length of time the two groups spent in a hospital. The findings were consistent with a previous study conducted by the team in which the oral steroid was administered by parents in the home.

Professor Grigg explains, “The result of this large trial suggests that oral prednisolone should not be routinely given to preschool children presenting to the hospital with virus-induced wheezing.”

Tags: London Insituite of Cell and Molecular Science, oral steroid, prednisolone, wheezing

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