Vascular endothelial growth factor (VEGF), a protein necessary for normal blood vessel growth and stimulating blood vessel growth, has been found to be behind cell overgrowth in the development of polyps characterizing one of the most severe forms of sinusitis.

The finding was revealed by researchers at the Johns Hopkins and appeared in an issue of the American Journal of Respiratory and Critical Care Medicine.

From Sciencedaily.com:

Kim explains that surgery to remove the polyps is one of the most common treatments for this disease. However, nasal and sinus polyps in these patients almost always regrow. “Once the patient has entered the cycle of growing polyps, it’s very hard to get out,” she says. Another common treatment is oral steroids, but these drugs are fraught with many harmful side effects and also only temporarily treat the disease.

She and her Johns Hopkins colleagues have long studied sinusitis, often growing sinus cells isolated from patients in petri dishes. After noticing that cells from patients with polyps typically multiplied faster than cells from normal patients, the researchers speculated that cells from polyp patients might be producing extra amounts of some type of growth factor, a protein that encourages cell growth.

Jean Kim, M.D., Ph.D., assistant professor in the Departments of Otolaryngology and Allergy and Clinical Immunology at the Johns Hopkins University School of Medicine, and a researcher at the Johns Hopkins Allergy and Asthma Center at the Johns Hopkins Bayview Medical Center, said that this kind of sinusitis isn’t subtle.

Tags: Oral Steroids, sinusitis, steroids, VEGF

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