A team of researchers from University of the Basque Country is working on analogues of the C1P molecule for developing anti-inflammatory drugs affecting healthy cells.

Currently, there are two types of anti-inflammatory drugs: steroids and those known as NSAID (Non-steroidal anti-inflammatory drugs). NSAID are the most widely-used drugs as they have fewer side effects and have an effect over a wider spectrum.

From Sciencedaily.com:

The team led by Antonio Gómez-Muñoz, from the Department of Biochemistry and Molecular Biology at the Science and Technology Faculty of the University of the Basque Country (UPV/EHU), is investigating alternatives to current anti-inflammatory drugs, creating synthetic analogues of the C1P (ceramide-1-phosphate) molecule. This molecule was discovered in 1990 in a case of human leukaemia. After synthesising it in the laboratory, it was observed that it was an important mytogenic agent (provoking cell growth and blocking the natural death of the cells). Moreover, it causes cell inflammation, i.e. when the cells detect the presence of this molecule, they secrete molecules that generate inflammation – prostaglandin and cytokine cells, for example.

The Basque research team was able to cancel the inflammatory capacity of the C1P molecule to be used as an anti-inflammatory drug for specific cell types without affecting other cells.

Tags: C1P molecule, Non-steroidal anti-inflammatory drugs, NSAID, steroids

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