A lower incidence of glucose intolerance and a higher incidence of rejection may occur necessitating the need for diabetes treatment, as per a new study on early steroid withdrawal following transplantation of liver.

The results of this study on early steroid withdrawal appeared in an issue of Liver Transplantation, which is the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS).

From News-Medical.Net:

“Although the incidence of acute rejection in the placebo group was increased, it was easily controlled in most of the cases and did not affect long-term graft histology or survival,” the authors note, adding that the increase may ultimately be acceptable if steroids could be eliminated. However, the main goal of steroid elimination is to reduce metabolic complications and this study showed no difference in cholesterol or hypertension, with a trend toward a decreased incidence of diabetes in the placebo group.

The authors conclude: “Indeed, while there are many arguments in favor of corticosteroid withdrawal beyond 3 months posttransplantation, in terms of safety and efficacy, our study demonstrates that earlier withdrawal at day 14 is not completely safe in terms of rejection, but seems efficient in terms of improvement of glucose tolerability,” which could decrease long-term mortality due to cardiovascular disease.

It is worthwhile to note here that this first double-blind placebo-controlled study was initiated for evaluating the effects of early steroid withdrawal so that medical practitioners can have a clear and complete understanding of the subject and be on the same knowledge platform.

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