Role of stem cells for treating Crohn's disease analyzedThe role of stem cells for “rebooting” the immune system and offering a cure for Crohn’s disease is under microscope with University of Nottingham researchers launching a major clinical trial to find the same.

The researchers are ascertaining whether stem cells obtained from a patient’s own body can be used to offer effective, long-term remissions for tens of thousands of people.

From News-Medical.Net:

The Europe-wide trial, which is currently recruiting patients, is the first of its kind in the world to treat Crohn’s. The disease is a chronic ongoing condition that most commonly affects the small intestine and colon. It causes inflammation, deep ulcers and scarring to the wall of the intestine, with main symptoms including pain in the abdomen, diarrhoea, fatigue and weight loss.

It affects around 60,000 people in the UK, with 3-6,000 new cases being diagnosed each year. Currently it has no cure. Normal treatment includes steroids, which cannot be taken long-term, and immune suppressant drugs.

But if the Nottingham-led stem cell therapy is successful, Professor Chris Hawkey and colleagues Dr Paul Fortun and Dr Tony Shonde believe that in the future it could just possibly mean a cure for up to 50 per cent of sufferers. The study is featured on a new TV series starting on November 1 on the Community Channel.

The stem cell study into Crohn’s Disease at The University of Nottingham is funded by the Broad Medical Research Program of The Eli and Edythe Broad Foundation, a philanthropic organization based in California.


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