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Short-term Topical Corticosteroid can offer relief for Acute Psoriasis Patients

Short-term Topical Corticosteroid can offer relief for Acute Psoriasis Patients In a study conducted by Alexander Kreuter, M.D, from Ruhr University of Bochum, Germany, and colleagues, it was suggested that a short-term application of topical corticosteroids and maintenance with a less potent agent can help patients with intertriginous psoriasis (IP).

From Bio-Medicine.Org:

In this study, Alexander Kreuter, M.D, from Ruhr University of Bochum, Germany, and colleagues conducted a randomized controlled trial that compared 1 percent pimecrolimus (a new anti-inflammatory drug), 0.005 percent calcipotriol, 0.1 percent betamethasone and the vehicle (a similarly appearing cream with no active drug) in the treatment of IP with a four-week treatment period and a six-week follow-up without therapy. A total of 80 adult patients with the clinical diagnosis of IP were included, 20 patients in each of the four treatment groups.

“After four weeks of treatment, the three active compounds and the vehicle resulted in a significant decrease in mean (average) M-PASI score [Modified Psoriasis Area and Severity Index] (86.4 percent for 0.1 percent betamethasone, 62.4 percent for 0.005 percent calcipotriol, 39.7 percent for 1 percent pimecrolimus and 21.1 percent for vehicle),” the researchers found. “The 0.1 percent betamethasone was significantly more effective than 1 percent pimecrolimus during the study period.”

These findings are expected to offer relief to all those IP patients who complain of intense itching, soreness, and irritation from sweating. It was previously believed that application of topical corticosteroids has side-effects with long-term use but this study refuted all such beliefs.

In a nutshell, it was remarked during the study that a short-term application of corticosteroids for acute disease followed by maintenance treatment with any of the less potent agents is regarded as a reasonable approach for the treatment of intertriginous psoriasis (IP).

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