The manner in which genes are expressed in rodents is affected by intermittent signaling by steroid hormones, according to a research by scientists at the University of Bristol and the National Cancer Institute (NCI), USA.

The research appeared online and appeared in the September 2009 issue of Nature Cell Biology.

From News-Medical.Net:

In this new study, the researchers demonstrate that ultradian hormone stimulation induces the pulsed expression of genes (known as gene pulsing) over the same period, both in cultured cells and in animal models. Initially, the researchers administered corticosterone, a naturally occurring glucocorticoid hormone in rodents, in a pulsed manner to cultured mouse cells and then observed that the levels of newly synthesized RNA from glucocorticoid receptor-regulated genes tracked precisely with the hormone pulses.

The reported research results argue that gene pulsing regulated by glucocorticoid receptors is directly linked to varying levels of gene activity. Professor Stafford Lightman, head of the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, at the University of Bristol, said: “We have previously shown that the hormone cortisol is released in pulses in man as well as rodents. The present results now show that this pattern of hormone release is critical for good health and provides a novel concept for new drug design.”

The finding is expected to have implications for understanding how steroids work and can help in opening up novel avenues for development of new therapies.

Tags: cortisol, glucocorticoid, steroid hormones, steroids

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