A reduced glucose intolerance incidence and an increased rejection incidence can happen suggesting an urgent need for the treatment of diabetes, according to a study on early steroid withdrawal following liver transplantation.

The study results were presented in an issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS).

From News-Medical.Net:

“Although the incidence of acute rejection in the placebo group was increased, it was easily controlled in most of the cases and did not affect long-term graft histology or survival,” the authors note, adding that the increase may ultimately be acceptable if steroids could be eliminated. However, the main goal of steroid elimination is to reduce metabolic complications and this study showed no difference in cholesterol or hypertension, with a trend toward a decreased incidence of diabetes in the placebo group.

The authors conclude: “Indeed, while there are many arguments in favor of corticosteroid withdrawal beyond 3 months posttransplantation, in terms of safety and efficacy, our study demonstrates that earlier withdrawal at day 14 is not completely safe in terms of rejection, but seems efficient in terms of improvement of glucose tolerability,” which could decrease long-term mortality due to cardiovascular disease.

The first-of-its-kind double-blind placebo-controlled study was aimed at examining the early steroid withdrawal effects for helping practitioners to gain a clear, complete understanding of the subject and be on the same knowledge platform.

Tags: corticosteroid, early steroid elimination, early steroid withdrawal, steroid, steroid elimination

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