A natural defense mechanism against diseases of the heart can be switched on by steroids sold as health supplements, according to researchers at the University of Leeds.

A previously-unknown ion channel in human blood vessels was identified by biologists at the University of Leeds. This ion channel can prove useful in inhibiting the production of proteins (cytokines) driving the early stages of heart disease.

From News-Medical.Net:

They found that this protective effect can be triggered by pregnenolone sulphate – a molecule that is part of a family of ‘fountain-of-youth’ steroids. These steroids are so-called because of their apparent ability to improve energy, vision and memory.

Importantly, collaborative studies with surgeons at Leeds General infirmary have shown that this defence mechanism can be switched on in diseased blood vessels as well as in healthy vessels.

So-called ‘fountain of youth’ steroids are made naturally in the body, but levels decline rapidly with age. This has led to a market in synthetically made steroids that are promoted for their health benefits, such as pregnenolone and DHEA. Pregnenolone sulphate is in the same family of steroids but it is not sold as a health supplement.

“The effect that we have seen is really quite exciting and also unexpected,” said Professor David Beech, who led the study. “However, we are absolutely not endorsing any claims made by manufacturers of any health supplements. Evidence from human trials is needed first.”

Forecasted benefits of ‘fountain of youth’ steroids could be more if used in a combination with healthy lifestyle strategies such as exercise ad cholesterol lowering drugs, as per the research.

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