Study shows Plavix allergic reactions can be treated with steroids and antihistamines According to doctors from Thomas Jefferson University Hospital, treatment with a combination of steroids and antihistamines can alleviate Plavix allergic reaction symptoms.

Plavix is a widely-prescribed drug also known by the name clopidogrel.

Primary Investigator Michael P. Savage, M.D., director, Cardiac Catheterization Laboratory at Thomas Jefferson University Hospital and Kimberly L. Campbell, M.D., cardiology fellow and lead author, presented their findings at the American College of Cardiology’s Annual Scientific Session on March 30, 2009.

From Sciencedaily.com:

John R. Cohn, M.D., chief of Adult Allergy at Thomas Jefferson University and Hospitals and a key contributor to the study noted, “Previously, when patients had an allergic reaction to Plavix we would give an alternative drug but they can have their own side effects. Rather than giving the secondary drug we concentrated on suppressing the patient’s allergic symptoms they were having to Plavix by administering low doses of steroids and antihistamines while continuing the drug. What we found was that most of our patients became tolerant to Plavix, essentially becoming ‘desensitized’ to the drug enabling them to continue treatment. Once this occurred we were able to discontinue the steroids and even the antihistamines.”

Previous anecdotal studies had suggested that some patients can be desensitized to Plavix but this is hailed as the first systematic study for demonstrating drug allergy could be easily and effectively managed without discontinuing the drug usage after a reaction has been experienced.


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