According to a finding reported in Proceedings of the National Academy of Sciences Online Early Edition, a protein known for regulating androgen receptor expression may be the focal point to stage and treat testosterone-fueled prostate cancer.

This finding was reported by researchers from the College of Georgia.

Dr. Yehia Daaka, Distinguished Chair in Oncologic Pathology in the MCG School of Medicine and co-author of the study, said that an increase in the number of androgen receptors is considered to be behind the progression of prostate cancer in men with advanced disease.

Collaborators on this study included Dr. Vijayabaskar Lakshmikanthan, postdoctoral fellow; Dr. Lin Zou, former postdoctoral fellow;  Jae Kim, graduate student; Dr. Nidia C. Messias, assistant professor; and Dr. Zhongzhen Nie, assistant professor; from the MCG Department of Pathology; and Drs. Allison Michal, and Jeffrey L. Benovic from Thomas Jefferson University.

Tags: βarrestin2, prostate cancer, steroids, testosterone

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According to researchers from the Medical College of Georgia, a protein that is helpful in regulating expression of androgen receptors may prove to be a new focal point for staging and treating testosterone-fueled prostate cancer.

It was noted that levels of the protein, βarrestin2, were lower in certain prostate cancer cells than in normal prostate cells. It was also noted that the expression of testosterone-fed androgen receptors is higher in such cases.

The findings were reported in Proceedings of the National Academy of Sciences Online Early Edition.

The study’s corresponding author, Dr. Yehia Daaka, Distinguished Chair in Oncologic Pathology in the MCG School of Medicine, said that an increase in the volume of androgen receptors is considered to be behind prostate cancer progression in men with advanced complication.

Tags: βarrestin2, prostate cancer, protein, steroids, testosterone

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