According to a study of JAMA, a combination of antibiotic and steroids is useful for treating acute sinusitis with less than severe symptoms.

Acute sinusitis is a sinus infection that is a common clinical problem with symptoms similar to other illnesses, and is often observed in general masses. Researchers showed that anti-inflammatory drugs such as topical steroids are quite beneficial in cases of acute sinusitis.

From Brightsurf.com:

A comparison of common treatments for acute sinusitis that included an antibiotic and a topical steroid found neither more effective than placebo, according to a study in the December 5 issue of JAMA.

The researchers found that the proportions of patients with symptoms lasting 10 or more days were 29 of 100 (29 percent) for amoxicillin vs. 36 of 107 (33.6 percent) for no amoxicillin; and 32 of 102 (31.4 percent) for topical budesonide vs. 33 of 105 (31.4 percent) for no budesonide. Secondary analysis suggested that nasal steroids were significantly more effective in patients with less severe symptoms at baseline.

To determine the effectiveness of the antibiotic amoxicillin and topical steroid budesonide in acute maxillary sinusitis, Ian G. Williamson, M.D., of the University of Southampton, England, and colleagues conducted a double-blind randomized placebo-controlled trial.

240 adults were divided into four groups, antibiotic and nasal steroid (500 mg of amoxicillin 3 times per day for 7 days and 200 ìg of budesonide in each nostril once per day for 10 days); placebo antibiotic and nasal steroid; antibiotic and placebo nasal steroid; placebo antibiotic and placebo nasal steroid.

All this showed that the nasal steroids were effective to patients who had less severe symptoms of sinusitis.

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A new drug compound has been identified by the researchers at the University of Southern California and according to them the drug appears to target tumor cells and surrounding blood vessels without showing any negative side effect usually associated with Cox-2 inhibitors.

As per the data presented at the AACR 100th Annual Meeting 2009, the compound named 2.5-dimethyl-celecoxib (DMC) would have a strong anti-tumor effect even while attacking the vasculature that provides the blood supply necessary for tumor growth.

Florence M. Hofman, professor of pathology at the Keck School of Medicine of USC, said “If left behind, the blood vessels within the tumor will help the tumor cells to survive and re-grow.” He further added that they believed that DMC might prove useful in the treatment of brain tumors, such as gliomas, which are highly vascular and also appeared to be a promising long-term treatment as it did not have the negative cardiovascular effects typically associated with Cox-2 inhibitors.

Hofman explained that Cox-2 inhibitors are most commonly used as anti-inflammatory drugs and have been effective in treating certain kinds of cancer. However, its long-term use can cause increased risk of heart attack and stroke while DMS mainatins its anti-tumor activity without inhibiting action of Cox-2.

From Science Daily:

Researchers at the University of Southern California have identified a new drug compound that appears to target tumor cells and surrounding blood vessels without the negative side effects typically associated with Cox-2 inhibitors.

The compound 2.5-dimethyl-celecoxib (DMC) appears to have a strong anti-tumor effect while also attacking the vasculature that provides the blood supply necessary for tumor growth, according to data presented at the AACR 100th Annual Meeting 2009. The findings were presented on April 19.

“If left behind, the blood vessels within the tumor will help the tumor cells to survive and re-grow,” says Florence M. Hofman, Ph.D., professor of pathology at the Keck School of Medicine of USC. “We believe that DMC will be particularly useful for treating brain tumors such as gliomas, which are highly vascular.

The study focused on testing the effectiveness of the DMC compound by isolating endothelial cells, which lines the interior surface of blood vessels, from human nonmalignant brain and glioma tissues and treating them with DMC.

In the study, the researchers found that the drug was not only cytotoxic to tumor-associated endothelial cells, but also suppressed cell proliferation process and migration occurrence without having toxic effects on normal tissues.

Hofman concluded with the saying that though their research focused mainly on brain tumors, but they believed that the drug might work for several different tumors that are dependent on blood vessels. However, further research would help them in understanding its full potential.

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