In a recent study, UK researchers reported that adolescent boys suffering from Asperger syndrome did not show any response linked with cortisol flow. Cortisol is a steroid hormone produced by the adrenal gland and released in response to stress. Upon awakening there is a surge to cortisol, which can explain some of the symptoms of Asperger syndrome.

The research team explained in an article published in the journal Psychoneuroendocrinology that along with other functions, the ability to adapt changes is controlled by the hypothalamic-pituitary-adrenal axis, which controls increase of cortisol during awakening period and this is referred as “the cortisol awakening response.”

“The cortisol awakening response is a robust and reproducible neuroendocrine phenomenon which has been positively correlated with psychological and physical well-being,” they added.

Dr. Mark Brosnan from University of Bath and his colleagues said that their study focused on the lack of response in individuals with Asperger syndrome. They also said that the research might help in explaining why such people face difficulties if even minor changes happened in their routine or environment.

From Reuters:

Upon awakening, there is normally a surge in cortisol, a steroid hormone produced by the adrenal gland and released in response to stress. Now, UK researchers report that this response is absent in adolescent boys with Asperger syndrome, which may explain some of the symptoms of the condition, such as the need for routine and resistance to change.

Among other functions, the ability to adapt to change is controlled by the hypothalamic-pituitary-adrenal axis, which controls the dramatic increase in cortisol upon awakening, referred to as “the cortisol awakening response,” the study team explains in an article in press in the journal Psychoneuroendocrinology.

“The cortisol awakening response is a robust and reproducible neuroendocrine phenomenon which has been positively correlated with psychological and physical well-being,” they add.

During the research, the investigators measured cortisol amount in saliva of 20 adolescent males with the problem and 18 normal control individual at the time of awakening and 30 minutes later. A significant cortisol awakening response was evident in the control group while in the Asperger group the response was absent.

Brosnan and colleagues write in the article that in the study, the typical marked rise in cortisol peaks around 30 minutes after waking and was found of required level only in developing control group. Therefore, Asperger syndrome, at least in adolescent males, appeared to be characterized by an impaired cortisol awakening response. However, they also said that further research would be required to address this “intriguing phenomenon” in Asperger syndrome.

Tags: Asperger syndrome, cortisol, steroid hormone

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