The chances of an asthma attack relapsing are reduced significantly when patients afflicted with asthma are given a short course of corticosteroids after they are discharged from the hospital, according to a Cochrane Systematic Review.

It was remarked by Carol Spooner, a colleague, that this review strongly supports the administration of systematic corticosteroids for treating outpatients after getting them discharged from the hospital post an asthma attack.

From News-Medical.Net:

This updated finding was drawn after reviewing data in six trials that together involved 374 people.

Between 12% and 16% of people who are discharged from hospital after having an asthma attack have a relapse within two weeks. “There is considerable debate about the best way of treating people who have asthma attacks, including the dose, method of delivery and timing of delivery of corticosteroids. Our research found clear evidence that people who arrived at a hospital with acute asthma and were well enough to be discharged benefited from the addition of corticosteroid therapy,” says lead author Professor Brian Rowe, who works at the University of Alberta, in Edmonton, Canada.

It was concluded by the review that use of steroids could possibly minimize the need of inhalers and may even prove effective for prolonging lives by as much as three weeks.

Tags: Asthma, corticosteroids, steroids

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Two separate studies conducted at Children’s Mercy Hospitals and Clinics have revealed that physicians could prevent complications in context to newborns and relieve worries of parents via genetic testing. This form of testing can be used for making advance predictions as to which all newborns would be requiring hospital readmission shortly after birth.

This research was led by Bridgette L. Jones, MD, allergy, asthma and immunology and clinical pharmacology specialist, and Carrie A. Vyhlidal, PhD, research scientist, pediatric clinical pharmacology, at Children’s Mercy Hospitals and Clinics, and a separate study was conducted by researchers at Children’s Mercy.

From Sciencedaily.com:

Up to 85 percent of hospital readmissions during the first two weeks of life are due to hyperbilirubinemia, more commonly recognized as jaundice. The condition can be concerning for new parents, and potentially devastating for the infant if not recognized and promptly treated. New research being led by Susan Abdel-Rahman, PharmD, professor of pediatrics at Children’s Mercy Hospitals and Clinics is identifying specific genetic markers that will enhance the ability to predict which newborns are at risk.

“This condition can be very harmful for newborn infants and scary for new parents,” said Dr. Abdel-Rahman. “Knowing in advance which babies are likely to experience symptoms can provide reassurance for parents and guidance for clinicians in determining which babies may benefit from more careful monitoring.”

The goal of the research is to develop an electronic tool that can be used by clinicians in nurseries nationwide to dramatically improve prediction of risk for hyperbilirubinemia and prevent complications due to late detection. The study will be among the largest of its kind, aiming to enroll 3,500 newborns.

Results of these studies are likely to help physicians for identifying which all of their young patients are expected to respond well or not to therapy involving steroids for treating asthma.

Tags: Asthma, genetic testing, steroids

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Sinusitis is a severe health complication affecting approximately 37 million individuals in the United States alone and a big majority of this population is also affected by asthma, which is a disease characterized by reversible airway obstruction.

A study was conducted to examine sinusitis symptom variations noticed by asthmatics and non-asthmatic population also suffering from sinusitis. The authors of “The Incidence and the Effect of Asthma on Consecutive Patients with Chronic Rhinosinusitis,” were Melanie W. Seybt MD, Kevin C. McMains MD, and Stilianos E. Kountakis MD PhD, all with the Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia, Augusta, GA.

From News-Medical.Net:

A retrospective chart review of 145 adult patients diagnosed with sinusitis at the Medical College of Georgia Rhinology Clinic between January of 2003 and September of 2003 was performed. Data included patient age, gender, presence or absence of asthma, presence of signs and symptoms including allergic rhinitis, nasal polyposis, nasal congestion, headache/facial pain, anosmia/hyposmia, rhinorrhea, and postnasal drip. Other variables evaluated included failure of medical management (prescription drugs) and need for surgical treatment. Patients were designated as asthmatic or non-asthmatic by patient history, use of asthma medications or prior pulmonary function tests.

All patients underwent medical therapy including intranasal steroids, saline nasal spray and irrigations, high-dose guaifenesin and appropriate antibiotic therapy when indicated, before being considered for surgery.

Findings of the study were presented at the American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting & OTO EXPO, at the Jacob K. Javits Convention Center, New York City, NY.

Tags: Asthma, intranasal steroids, sinusitis, steroids

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The risk of an asthma attack relapsing is minimized to a significant extent when affected patients are administered with a short course of corticosteroids after being discharged from the hospital post-attack, according to a Cochrane Systematic Review.

The review disclosed that administration of steroids to asthmatic patients could considerably reduce the use of inhalers; it was revealed that such benefits can last for as long as three weeks.

From News-Medical.Net:

This updated finding was drawn after reviewing data in six trials that together involved 374 people.

Between 12% and 16% of people who are discharged from hospital after having an asthma attack have a relapse within two weeks. “There is considerable debate about the best way of treating people who have asthma attacks, including the dose, method of delivery and timing of delivery of corticosteroids. Our research found clear evidence that people who arrived at a hospital with acute asthma and were well enough to be discharged benefited from the addition of corticosteroid therapy,” says lead author Professor Brian Rowe, who works at the University of Alberta, in Edmonton, Canada.

Carol Spooner, the review colleague, remarked that the systematic review strongly endorses the use of systematic corticosteroids to treat outpatients after getting discharged from the hospital after asthma attack.

Tags: Asthma, corticosteroids, steroid, steroids

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Nearly 37 million people in the United States alone are afflicted with sinusitis and a big part of this patient population is also affected with asthma, an inflammatory disease of the lungs which is characterized by reversible airway obstruction.

In order to ascertain the differences in symptoms of sinusitis experienced by asthmatics versus non-asthmatics, a study was entailed. The authors of “The Incidence and the Effect of Asthma on Consecutive Patients with Chronic Rhinosinusitis,” were Melanie W. Seybt MD, Kevin C. McMains MD, and Stilianos E. Kountakis MD PhD, all with the Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia, Augusta, GA.

From News-Medical.Net:

A retrospective chart review of 145 adult patients diagnosed with sinusitis at the Medical College of Georgia Rhinology Clinic between January of 2003 and September of 2003 was performed. Data included patient age, gender, presence or absence of asthma, presence of signs and symptoms including allergic rhinitis, nasal polyposis, nasal congestion, headache/facial pain, anosmia/hyposmia, rhinorrhea, and postnasal drip. Other variables evaluated included failure of medical management (prescription drugs) and need for surgical treatment. Patients were designated as asthmatic or non-asthmatic by patient history, use of asthma medications or prior pulmonary function tests.

All patients underwent medical therapy including intranasal steroids, saline nasal spray and irrigations, high-dose guaifenesin and appropriate antibiotic therapy when indicated, before being considered for surgery.

The findings were presented at the American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting & OTO EXPO, at the Jacob K. Javits Convention Center, New York City, NY.

Tags: Asthma, intranasal steroids, sinusitis, steroids

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A potential drug has been identified and about to undergo trials in humans for treating hay fever and asthma.

The drug, RPL554, apparently has the ability to effectively treat respiratory diseases and does not lead to side effects that are usually common characteristics of many of the currently used medications.

From News-Medical.Net:

Dr. Page who is a professor of pharmacology at King’s College London, says RPL554 is a single molecule that does both jobs and should have fewer side effect profile and he says they are cautiously optimistic that they can develop a treatment where one puff will last all day.

Current treatments for asthma and hay fever sufferers are beta-agonists, which open up the airways, and inhaled steroids, which dampen down the inflammation that causes irritation – they are either taken together or singly.

But they have serious side effects, including possible harm to the cardiovascular system and the ‘shakes’ reported by many patients from excess use.

Experts say little progress has been made recently with alternative, effective and practical treatment options for a wide range of people with asthma and hay fever and by combining anti-inflammatory properties and the ability to overcome airway narrowing in a single long-lasting dose via the nose, RPL554 could offer real hope of a significant breakthrough.

It was remarked by Dr. Clive Page, chairman of Verona Pharma, which is developing the treatment, that his company is also ascertaining other novel compounds to tackle respiratory diseases on the lines of anti-inflammatory substances found in starfish and a treatment for coughs.

Tags: Asthma, hay fever, Inhaled steroids, RPL554, steroids

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Black teenagers are more likely to develop steroid-resistant asthma than their white counterparts, according to a research conducted at the National Jewish Medical and Research Center.

It was disclosed in the study that black asthmatic teens are more likely to be sick and suffer from a higher mortality rate than white teens with asthma.

From News.Bio-Medicine.Org:

“Our results suggest that children with steroid-resistant asthma are more likely to be African-American, to have required treatment with oral steroids at an earlier age and to require larger amounts of oral steroids for only marginal control of their asthma,” said Joseph Spahn, M.D., a pediatric allergist and director of the Immunopharmacology Lab at National Jewish.

Other recent epidemiological studies have shown that blacks with asthma are sicker and have a higher mortality rate than whites with asthma. Doctors at National Jewish now are trying to determine whether blacks have a more vigorous immune response to airway inflammation–which means that higher doses of steroids must be used to control inflammation–or a poor response to steroids secondary to a genetic resistance to the drugs.

“The theory is that with ongoing airway inflammation you get worsening asthma and diminished steroid sensitivity,” Dr. Spahn said.

This study of 164 teen-agers treated at National Jewish also showed that 25 percent of the group was steroid resistant. Children with less than a 15 percent improvement in lung function following a “burst” of inhaled steroids–high doses over seven days–were considered steroid resistant.

“Twenty-five percent of the kids admitted to National Jewish have steroid-resistant asthma, which is much greater than anyone thought,” Dr. Spahn said.

African-American children are prone to steroid-resistant asthma, according to Joseph Spahn, M.D., a pediatric allergist and director of the Immunopharmacology Lab at National Jewish.

The study was published in the Journal of Allergy and Clinical Immunology.

Tags: Asthma, Inhaled steroids, Oral Steroids, steroid

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According to a new study by researchers at Washington University School of Medicine and other institutions, young children with asthma can be treated in a better way by increasing doses of steroids or adding more drugs to the asthma therapy.

Results of this study have implications to help medical practitioners to predict which all of the available treatment options will help their patients the most.

Robert C. Strunk, M.D., and Leonard B. Bacharier, M.D., both Washington University pediatric asthma specialists at St. Louis Children’s Hospital were co-authors for this study.

From Sciencedaily.com:

“We used a few complicated and expensive tests we thought would help us determine which drug would be better, but they didn’t help, so we can avoid these tests,” says Strunk, the Donald Strominger Professor of Pediatrics at Washington University School of Medicine.

Although 98 percent of patients in the study showed improvement on at least one of the step-up options, there were still 120 asthma exacerbations, or attacks, among the 165 patients that required treatment with prednisone, a corticosteroid commonly used after an exacerbation that prevents the release of inflammatory substances in the body. Bacharier says that indicates none of these treatments provide perfect asthma control.

“There may not be an ideal therapy for every patient, but these step-up treatments allow for improved asthma control and outcomes over leaving them on low-dose steroids alone,” Bacharier says.

The study was published online March 2, 2010, by the New England Journal of Medicine and presented the same day at the American Academy of Allergy, Asthma and Immunology’s annual meeting in New Orleans.

Tags: Asthma, asthma therapy, corticosteroid, Prednisone, steroids

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Asthma management is easy and effective with inhaled corticosteroids when compared with sodium cromoglycate besides helping in normal functioning of the lungs, as per a study.

The dominance of inhaled corticosteroids increase with moderate low doses when compared to low doses, according to Dr James Guevara, Department of Pediatrics at the University Of Pennsylvania School Of Medicine in Philadelphia and lead review author of this study.

From News.Bio-Medicine.org:

Inhaled corticosteroids (ICS) and sodium cromoglycate (SCG) are both used to help people with asthma. SCG is believed to have a low risk of causing long-term side effects, but despite anxieties relating to routine use of steroids, the use of ICS has steadily increased since the 1990s.

While they are both known to work, there has previously been a debate as to whether one is superior to the other.

By pooling data from randomized controlled trials that directly compared the effects of ICS and SCG the Cochrane Review Authors could assess the relative benefits of each. They considered measures of lung function, asthma control and the use of general healthcare services such as GPs and hospitals.

Their conclusion was that ICS controls asthma better than SCG and that it also leads to improved lung function. They were, however, unable to decide whether there were differences in side-effects as most of the trials ran for too short a time to assess long-term outcomes.

“The superiority of ICS over SCG appears to increase when patients use moderate doses of ICS, compared with when low doses of ICS are used,” says lead Review Author Dr James Guevara, who works in the department of Pediatrics at the University of Pennsylvania School of Medicine in Philadelphia.

It was concluded by Dr Guevara that inhaled corticosteroids are a better option for asthmatic patients than sodium cromoglycate when it comes managing the disease.

Tags: Asthma, inhaled corticosteroids, sodium cromoglycate, steroids

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Adults and children afflicted with asthma can exercise better control over the disease with inhaled corticosteroids than with cromolyn, according to a study conducted by James Guevara, M.D., of the University of Pennsylvania School of Medicine and colleagues.

The researchers made comparisons between inhaled corticosteroids and cromolyn to find the better between the two for providing relief to patients with asthma.

From News.Bio-Medicine.Org:

Cromolyn’s manufacturer has changed several times during the past two decades, which may also explain why the drug’s popularity has waned, Storms said. The succession of companies “did not spend one dollar in research in the past 20 years to study cromolyn. All of the data are old and most are forgotten,” he said.

The Cochrane reviewers examined 17 studies involving 1279 children and eight studies involving 321 adults with asthma. They found no differences in serious side effects between those using the steroids and those using cromolyn, but acknowledge that adverse effects were reported inconsistently.

Guevara and colleagues conclude that inhaled corticosteroids were superior to cromolyn regardless of the severity of the asthma. They suggest the results are so decisive that future studies comparing the two types of drugs “may not be warranted.”

It was revealed by the study that adults and children with asthma and treated with inhaled steroids experienced three fewer severe asthma flare-ups each year on an average and made less use of asthma inhalers when compared to asthma patients treated with cromolyn.

Tags: Asthma, cromolyn, inhaled corticosteroids, Inhaled steroids, steroids

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