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Thursday 10, Feb 2011

  Infliximab better than steroids for Crohn’s Therapy

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Infliximab better than steroids for Crohn's TherapyIn a study with 129 patients, initial treatment with infliximab plus azathioprine in patients with moderate to severe Crohn’s disease leads to more remissions when compared to a standard approach starting with topical or systemic steroid treatment.

Geert D’Haens, M.D., said at the 13th United European Gastroenterology Week, “Steroids are not necessary for treating Crohn’s disease.”

The study was sponsored by Centocor and Schering-Plough.

Friday 04, Feb 2011

  Budesonide could replace Prednisone for autoimmune hepatitis

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Budesonide could replace Prednisone for autoimmune hepatitisDr. Michael P. Manns and his colleagues said in an article appearing in the October issue of Gastroenterology that a combination of budesonide plus azathioprine achieves and maintains remission of autoimmune hepatitis as well as standard prednisone therapy does, while sparing patients many of the adverse effects of steroids.

Dr. Manns of Hannover (Germany) Medical School and his associates compared the safety and efficacy of the budesonide combination with the standard therapy of prednisone with azathioprine.

From Internalmedicinenews.com:

In the first phase of the study, 208 patients aged 10-70 years were randomly assigned to receive budesonide (103 subjects) or prednisone (105 subjects) with azathioprine for 6 months. Budesonide was given in 3-mg oral doses three times daily, a regimen that was decreased to twice daily if remission occurred. Prednisone was started at 40 mg/day and tapered to 10 mg/day.

Azathioprine was administered at a dose of 1-2 mg/kg per day, according to the clinician’s judgment. None of the study subjects had any evidence of cirrhosis.

A total of 176 subjects completed this phase. Reasons for withdrawal included lack of efficacy (3 patients taking budesonide and 12 taking prednisone), adverse events (3 patients taking budesonide, 3 taking prednisone), and lack of compliance with the study protocol (4 patients taking budesonide, 2 taking prednisone).

The study was described by researchers as the largest prospective, randomized, multicenter trial published to date for the treatment of autoimmune hepatitis.

Wednesday 05, Jan 2011

  Steroids help kidney patients preserve kidney function

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Steroids help kidney patients preserve kidney functionAccording to a study appearing in an issue of the Journal of the American Society of Nephrology (JASN), patients with IgA nephropathy can benefit from use of steroids. It was revealed by the study that individuals suffering from the kidney disease can prevent or delay loss of kidney function with steroids.

The list of study co-authors included Simeone Andrulli, Lucia Del Vecchio, Francesco Locatelli (Ospedale di Lecco), Antonello Pani (Ospedale di Cagliari), Patrizia Scaini (Ospedale di Brescia), Giambattista Fogazzi (Ospedale Maggiore di Milano), Bruno Vogt (Inselspital di Berna), Vincenzo De Cristofaro (Ospedale di Sondrio), Landino Allegri (Ospedale di Parma), Lino Cirami (Ospedale di Firenze), and Aldo Deni Procaccini (Ospedale di Foggia).

The kidney complication is an autoimmune disease, which is regarded as a major cause of end-stage failure of the kidneys in younger people.

Thursday 30, Dec 2010

  Steroids beneficial for preserving kidney function

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Steroids beneficial for preserving kidney functionAccording to a finding published as part of a study in an issue of the Journal of the American Society of Nephrology (JASN), treatment with steroids can prove to be a beneficial option for delaying or preventing loss of kidney function in patients with IgA nephropathy, a type of kidney disease.

The kidney complication is an autoimmune disease affecting the kidneys and is considered as a major cause of end-stage failure of the kidneys in younger people.

The list of study co-authors included Simeone Andrulli, Lucia Del Vecchio, Francesco Locatelli (Ospedale di Lecco), Antonello Pani (Ospedale di Cagliari), Patrizia Scaini (Ospedale di Brescia), Giambattista Fogazzi (Ospedale Maggiore di Milano), Bruno Vogt (Inselspital di Berna), Vincenzo De Cristofaro (Ospedale di Sondrio), Landino Allegri (Ospedale di Parma), Lino Cirami (Ospedale di Firenze), and Aldo Deni Procaccini (Ospedale di Foggia).

Friday 05, Nov 2010

  Drug combination useful for remission in Crohn’s disease

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drug-combination-useful-for-remission-in-crohns-diseaseA Mayo Clinic study has suggested that the combination of biologic therapy with immune-suppressing drugs first instead of the drugs alone can be more than just beneficial to prompt remission from Crohn’s disease in a better way.

The study was published in the April 15, 2010 issue of the New England Journal of Medicine.

The study results are worthwhile enough to initiate a change in clinical practice, according to William Sandborn, M.D., gastroenterologist and vice chair of the Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester.

Wednesday 01, Sep 2010

  Kidney function preserved with steroids

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Kidney function preserved with steroidsTreatment with steroids could lead to prevention or delay loss of kidney function in patients with IgA nephropathy, a type of kidney disease. This finding will be disclosed by a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

This kidney complication is an autoimmune disease that affects the kidneys and regarded as a major cause of end-stage failure of the kidneys in younger people.

The list of study co-authors included Simeone Andrulli, Lucia Del Vecchio, Francesco Locatelli (Ospedale di Lecco), Antonello Pani (Ospedale di Cagliari), Patrizia Scaini (Ospedale di Brescia), Giambattista Fogazzi (Ospedale Maggiore di Milano), Bruno Vogt (Inselspital di Berna), Vincenzo De Cristofaro (Ospedale di Sondrio), Landino Allegri (Ospedale di Parma), Lino Cirami (Ospedale di Firenze), and Aldo Deni Procaccini (Ospedale di Foggia).

Thursday 20, May 2010

  Drug combination found effective for Crohn’s disease remission

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Drug combination found effective for Crohn's disease remissionA study led by Mayo Clinic recently suggested that a combination of immune-suppressing drugs first instead of immune-suppressing drugs alone may prove useful for bringing remission from Crohn’s disease.

It was found that a combination of infliximab plus azathioprine allows more patients to achieve mucosal healing and remission than a therapy with azathioprine alone.

William Sandborn, M.D., gastroenterologist and vice chair of the Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, said that these results are good enough to change clinical practice.

The study was published in the April 15, 2010 issue of the New England Journal of Medicine.

Sunday 28, Mar 2010

  Liver transplant survival adversely affected by alcohol relapse

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Liver transplant survival adversely affected by alcohol relapseA study has found that alcohol relapse adversely affects survival rates after liver transplantation, only after 10 years.

The study results appeared in Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). This journal is published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience.

The study authors said that risk-reducing measures like quitting smoking and abstaining from alcohol must be encouraged in the affected patients.

Tuesday 16, Mar 2010

  Severe autoimmune hepatitis caused by Varicella zoster infection

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Severe autoimmune hepatitis caused by Varicella zoster infectionAutoimmune hepatitis (AIH) is a chronic liver inflammation of an unknown etiology, which is characterized by the presence of circulatory autoantibodies and ongoing liver tissue damage.

In the last few years, the understanding about this complication has grown and it is considered that specific agents such as drugs and viruses may trigger the process of self-induced liver damage in genetically predisposed individuals.

This case of severe AIH following varicella zoster infection in a 23-year-old man was presented by Dr. Waleed K Al-Hamoudi from Saudi Arabia. It was published in the World Journal of Gastroenterology.

Sunday 21, Feb 2010

  Donor age irrelevant for influencing effect on long-term liver transplant survival

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Donor age irrelevant for influencing effect on long-term liver transplant survivalThe effect of donor age has no long-term effect on survival and recurrence of hepatitis C after liver transplantation, as per a study.

The study results appeared in an issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS).  This journal is published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience.

It was concluded by the authors that donor age didn’t influence the progression of recurrent hepatitis C and the absence of azathioprine and steroids do play a role.

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