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Thursday 15, Mar 2012

  Rampant use of steroids common with young men

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According to a new review, anabolic steroids have become a “short cut to an eye-catching physique” for more and more youthful men in the East Riding.

Once the exclusives of bodybuilders, steroids, are the most typical of all drugs now and are used by old gym customers and beginner players.

Mr Margetts, East Riding Council’s substance misuse manager, added: “We are seeing people turn up at minor injury units who have injected into veins not the muscle, which can mean they get phlebitis or inflammation. It’s not a particularly brilliant idea to fill yourself up with a synthetic testosterone in the first place – just stick to weights. “Long-term heavy use is undoubtedly very dangerous.”

Tuesday 21, Feb 2012

  More young men injecting steroids

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According to a new report, steroids have become a “short cut to an attractive physique” for increasing numbers of young men in the East Riding.

Once the preserves of bodybuilders, steroids, are the most common and are used by recreational gym users and amateur sportsmen.

Mr Margetts, East Riding Council’s substance misuse manager, added: “We are seeing people turn up at minor injury units who have injected into veins not the muscle, which can mean they get phlebitis or inflammation. It’s not a particularly brilliant idea to fill yourself up with a synthetic testosterone in the first place – just stick to weights. “Long-term heavy use is undoubtedly very dangerous.”

Friday 17, Feb 2012

  Jail term for health shop owner

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In connection with the sale of illicit drugs and steroids under the counter, a former Aylesbury shopkeeper has been jailed for 14 months.

Ricky Thomas, the 25-year old who ran Health Zone in the Cloisters, supplied customers with a wide variety of drugs commonly abused by bodybuilders, including Viagra, testosterone, Diazepam, and breast-reduction drugs.

“His customers were body builders, so they knew what they were doing. He is only 25, and he is a young man with promise,” Jones said.

Sunday 29, Jan 2012

  King Mo will not appeal positive steroid test

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Former Strikeforce light heavyweight champion Muhammed Lawal is not expected to file an appeal with the Nevada State Athletic Commission (NSAC).

Lawal tested positive for the anabolic steroid Drostanolone following a Jan. 7, 2012, win over Lorenz Larkin.

“When I went to Max Muscle, I figured you can’t buy steroids at a Max Muscle. It’s a chain store,” he said. “That’s like going to a grocery store and buying something illegal there. I guess that’s the mistake I made. When I looked at the bottle, it just had a bunch of numbers on it. It had the ingredients. I didn’t see anything that looked illegal on the bottle, to be honest with you,” Lawal said.

Saturday 28, Jan 2012

  Dianabol

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Dianabol is one of the most common oral steroids called Methandrostenolone. A derivative of testosterone, Dianabol is one of the most popular steroids and exhibits strong anabolic and moderate androgenic properties. Its easy usage and effectiveness is what makes this steroid widely accepted. Its chemical name is 17a-methyl-17b-hydroxy-1,4-androstadien-3-one 1-Dehydro-17 a methyltestosterone.

Dianabol, or D-bol as it is commonly addressed, is widely used because of its remarkable ability to build muscle strength in a relatively very short span of time. It also possesses a multifaceted approach in building the muscles without causing and loss of weight. The Methandrostenolone contained in Dianabol is its most active ingredient and acts in an ergogenic manner when orally administered.

Most common users of D-bol are athletes and particularly bodybuilders seeking maximum muscle mass within minimum time limits. Dianabol contains a powerful anabolic agent which upon entering the body, increases the synthesis of the proteins and also causes the retention of nitrogen in it. Increase in the levels of proteins helps in the balancing of nitrogen in the body which further aids in the development of adaptogenic properties in it. This allows the body to adapt according to increased workloads as well as fatigue.

Dianabol’s primary role is that it lets the acquired muscle protein in the body to stay. This anabolic drug is also known to show considerable growth in body insulin, a hormone produced in the liver. This creates a soothing effect in the body and users of this effective steroid are often seen talking about improved sleep, lower stress levels, better appetite and feeling of relaxation despite outside pressures. This is particularly the result of increased normalizing effect of Dianabol after the RNA synthesis during stress. However, in bodybuilders, it prevents the body from avoiding catabolic stress which helps them perform at a higher level and also recover fast after tedious training regime.

What makes D-bol so sought after is its ability to stimulate strength gain in the muscle in a very direct way. During phases of heavy physical and mental stress & irregular training and caloric retention, this anabolic steroid creates a temporary anabolic state which stops the breaking down of protein so that it releases amino acids in other muscles of the body, making them more intact and strong.

Despite being such a popular muscle-mass building steroid, Dianabol is not very often used in pre-contest cycles. This is particularly because it increasingly aromatizes to estrogen and causes high retention of fluid in the body. It is always advised to administer this anabolic drug in limited amount as high dosage over an extended period of time can strain the functioning of the liver. Some other apparent effects that might occur owing to heavy dosage such as 100mg per day are gynecomastia, acne, oily skin, testicular atrophy, deepening of the voice, hair loss, high blood pressure and loss of libido in some cases.

The dosage of Dianabol is variable. For men, it is advisable to start with 10mg per day which can be increased up to 25mg per day. Women wanting to take Dianabol with an intent to cut fat and gain muscle strength should start with 5mg per day and must not go beyond 10mg in a day.

The active life of this drug is about 3-5 hours. Since it is rapidly absorbed in the digestive juices in the stomach, it is best advised to take it with food and large amount of water to avoid abdominal cramps. The advanced testing systems nowadays can identify metabolites of Dianabol in the urine samples of the user, up to 4 weeks after the last dose is administered.

Being a popular drug, Dianabol is easily available. There are numerous sites on the internet which sell this steroid from where it can be ordered with or without a medical prescription. One should bear in mind that Dianabol is a highly potent drug and hence should be taken only under the supervision of a physician.

Wednesday 25, Jan 2012

  HCG

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Human chorionic gonadotropin, more commonly referred to as HCG is a glycoprotein consisting of a peptide chain of 244 amino acids. Its molecular weight is 36.7 kDa.

HCH is heterodimeric in nature composed of an α (alpha) subunit identical to that of follicle-stimulating hormone (FSH),luteinizing hormone (LH) and  thyroid-stimulating hormone (TSH) and a β (beta) subunit which forms a distinctive feature of HCG. It’s α (alpha) subunit has a peptide chain of 92 amino acids and β-subunit consists of 145 amino acids. This peptide chain is encoded by six highly-homologous genes, arranged in tandem with pairs inverted on its chromosome. These two subunits are known for creating a hydrophobic core which is surrounded by a high surface area-to-volume ratio, approximately 2.8 times that of that sphere. Most of the amino acids on the outer side are hydrophilic.

This glycoprotein hormone is primarily released in the body when a woman is pregnant. It is released by the developing embryo in the uterus and then later by the syncytiotrophoblast which is actually a part of the placenta surrounding the embryo. Some cancerous tumors are also known to cause the production of this hormone. Hence if it is found in high measures in a patient who is not pregnant, it plays an important role in help rule out any risk of cancer. However, it has still not been found whether the production of HCG is a contributing factor or a result of tumorigenesis taking place in the patient. The luteinizing hormone (LH) is a pituitary analog of HCG and is secreted in the pituitary gland of both males as well as females. Owing to its similarity to LH, this chorionic gonadotropin is clinically used to induce testosterone production in the testes of males and ovulation in the ovaries of females. It is also known to activate apoptosis and play an active role in cellular differentiation and proliferation.

Benefits of HCG:

  • A highly known benefit of HCG is that when combined with a low calorie diet, it triggers the hypothalamus to release upto 2000 to 4000 calories in a single day.
  • HCG when ingested orally is known to target the abnormal fat stored in the body. This fat mainly complies with lipids which do not burn even by dieting and rigorous workouts.
  • HCG intake greatly changes the appetite of a person. From large quantities ingested in a single meal, HCG administration naturally makes the person to eat smaller meals and this habit tends to stay with the person for life.
  • When taken orally, HCG initiates the body to lose some great amount of body fat as well as weight. The body will undergo contouring and one might see a decrease in its circumference until it adjusts itself to its metabolic weight.
  • As the person loses fat, his/her skin retracts improving the tenderness of the skin.
  • A major drawback associated with drugs used for weight loss is that low calorie in the body often leads to loss of muscle mass as well. However, in case of HCG there is no such side effect seen.

Users of HCG have also reported many beauty benefits of its use:

  • They have found that because of healthy eating their acne as well as black spots have greatly reduced.
  • People have experienced elimination of dark circles under the eyes as under HCG diet, fast food and sodas are not consumed which are the main causes of dark circles.

Beneficial in bodybuilding:

  • HCG happens to be one of the most desirable drugs for bodybuilders and people undergoing heavy workouts competitive purposes, for it helps in recovery of muscle soreness way much faster than other steroids.
  • Weight loss caused by HCG administration is rapid but is considered to be safe which is 20 to 40 pounds a month.

Human chorionic gonadotropin is largely employed as a tumor marker, as its β subunit is released by some cancerous cells. Therefore it is used for tracking seminoma, choriocarcinoma, germ cell tumors, hydatidiform mole formation and teratoma.

In order to experience long term benefits of HCG, it is important for the person to maintain the HCG diet as well as regular exercise regime.

Tuesday 24, Jan 2012

  IGF-1

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Somatomedin C is a protein found in humans and is commonly termed as Insulin-like growth factor 1 (IGF-1).  It is one of the most important hormones responsible for growth in children and has a molecular structure and size similar to that of Insulin.  It has a molecular weight of 7649 daltons and consists of a peptide chain with 70 amino acids in a single chain having three intramolecular disulphide bridges.

It is associated with the peptide family, commonly identified as the growth factors. Known to be a highly anabolic hormone, it is produced in liver and the peripheral tissues particularly in the cells of skeletal muscles. The presence of the Human Growth Hormone (HGH) in the body is considered to trigger the release of IGF-1 as its response. It is one of the most sought after substances by bodybuilders for the reason that it initiates the development of muscles in a very short period. As a result of rigorous training, the body experiences an increase in the Growth Hormone (GH) as well as the IGF-1 which causes the muscle cells to grow. Where GH is considered to have very strong anabolic properties, it is IGF which is believed to be responsible for its primary anabolic nature.

Growth hormone is mainly produced in the anterior pituitary gland which then flows into the blood stream stimulating the liver to produce IGF-1.  As a result, IGF-1  then  leads to the systemic body growth  of all the cells in the body mainly those of the  skeletal muscles, cartilage, bone, liver, kidney, nerves, skin, hematopoietic cell and the lungs. Apart from IFG’s insulin-like effects, IGF-1 also initiates regulated cell growth and development in the nerve cells and cellular DNA synthesis.

Deficiency of any of these two substances causes stunted growth in children who are then given recombinant GH to restore their condition.  People suffering from IGF-1 often suffer from Laron syndrome (Laron’s dwarfism) and are treated with recombinant IGF-1.

Normally 98% of IGF-1 is always seen to be bound to one of 6 binding proteins (IGF-BP).  The protein responsible for 80% binding of IGF is IGFBP-3and is bound to it in 1:1 molar ratio.

When administered, IGF-1 leads to the building of new muscle tissue by initiating the synthesis of protein along with the retention of nitrogen in the body. The prime functions associated with this are hyperplasia, which causes an increase in the muscle tissue and mitogenesis or the growth of new muscle fibers. This makes IGF -1 a highly favoured option for bodybuilders and power lifters seeking not only their muscle development but growth of muscle fibers as well.

Another benefit of employing IGF-1 is that it has a strong effect on the lipid metabolism of the body. In other words, it also plays a significant role in burning the body fat at a relatively fast rate. IFG-1 is also known to be a neuroprotector as well as a neuropromotor and finds its use in the improvement of functions related to the mind like reflexes, memory and ability to learn.

IGF-1 is employed as one of the most important substances required for the production of connective tissue in the joints, thereby ensuring appropriate bone density.

Being a highly potent drug for the development of muscle mass and fat-cutting, IGF’s Lr3 IGF-1 version is also considered to be equally powerful. Here Lr3IGF-1 stands for Long R3 Insulin-like Growth Factor-I or Long R3IGF-I.  It is a peptide of 83 amino acid analog of human IGF-I consisting of an entire human IGF-1 sequence. However, the only difference is that there is a substitution of an Arg for the Glu at position 3 and 13 amino acid extension at the N-terminus of the peptide.  It is for this reason that Long R3IGF-I is comparatively considered to be a more potent drug.

Some factors believed to cause changes in the levels of growth hormone (GH) and IGF-1 are the user genetic make-up, time of the day it is taken, age, sex, exercise status, stress level, nutrition level and body mass index (BMI). Reduction in IGF-1 signaling is also associated with the contribution of ‘anti-aging’ effects during calorie restriction phase.

A word of caution here is that increased use of IGF is often associated with enhanced risk of cancer.

Thursday 03, Nov 2011

  Inquiry launched into steroid dealing

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An inquiry has been launched by detectives into steroid-dealing after the death of a 23-year-old.

Police believe Lewis Allan, who died recently after falling ill at home in Eastbourne, used anabolic steroids over the last year.

A man has been arrested on suspicion of supplying drugs.

Tuesday 18, Oct 2011

  Kansas business owner indicted in steroid case

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Federal prosecutors alleged in an indictment that a Kansas business owner and a Maryland doctor illegally distributed more than $1.3 million worth of anabolic steroids.

According to court records, Baltazar, who allegedly wrote the prescriptions, did not see the patients in person.

Prosecutors are asking a judge to order the men to forfeit $1.36 million in proceeds from the alleged scheme.

Wednesday 31, Aug 2011

  Kidney damage possible in steroid-influenced bodybuilding

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Kidney damage possible in steroid-influenced bodybuildingAthletes using anabolic steroids for gaining muscle mass and strength could end up destroying their kidney function.

The finding was disclosed in a paper being presented at the American Society of Nephrology‘s 42nd Annual Meeting and Scientific Exposition in San Diego, CA.

It was also suggested that habitual use of steroids has serious harmful effects on the kidneys that were not previously recognized.

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