Avastin, taken alone or as a combination therapy, is highly effective in terms of improved response rates, survival rates, and progression-free survival times in patients suffering from recurrent glioblastoma, which is a deadly form of brain cancer.

It was remarked by Dr. Timothy Cloughesy, director of the Neuro-Oncology Program at UCLA’s Jonsson Comprehensive Cancer Center and senior author of the study that a combination of Avastin and CPT-11 or Avastin alone has the ability to improve the response rate and overall survival to a significant extent.

It was further remarked by Cloughesy that the study findings can be termed as useful to treat patients with recurrent glioblastoma as Avastin is effective for reducing brain swelling and doses of steroids.

Tags: Avastin, brain cancer, recurrent glioblastoma, steroids

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The targeted therapy Avastin, in a combination or isolation, has the capability of considerably increasing response rates, survival rates, and progression-free survival times in patients suffering from recurrent glioblastoma, a deadly form of brain cancer.

Dr. Timothy Cloughesy, director of the Neuro-Oncology Program at UCLA’s Jonsson Comprehensive Cancer Center and senior author of the study, remarked that Avastin alone and Avastin given with CPT-11 can improve the response rate and overall survival to a considerable extent.

Cloughesy remarked that the findings of this study constitute a huge breakthrough as Avastin has proved itself to be of great usefulness for treating patients with recurrent glioblastoma. It was also remarked that Avastin brings the level of brain swelling down and can even help in reducing the doses of steroids to ensure marked improvement in function.

Tags: Avastin, brain cancer, recurrent glioblastoma, steroids

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According to a recent study that was conduced at 11 centers across the country and published in the early online version of the Journal of Clinical Oncology, survival rate gets increased with Avastin in recurrent glioblastoma affected patients. It was revealed during the study that the targeted therapy Avastin, alone or in combination with CPT-11 (chemotherapy drug) can considerably increase progression-free survival times and survival rates in patients with a deadly form of recurrent brain cancer.

Dr. Timothy Cloughesy, director of the Neuro-Oncology Program at UCLA’s Jonsson Comprehensive Cancer Center and senior author of the study said that positive results from Avastin have promoted the FDA to an accelerated approval of Avastin in May 2009 for use in patients with recurrent glioblastomas.

Avastin is an angiogenesis inhibitor that neutralizes VEGF (vascular endothelial growth factor), which is a chemical signal stimulating the growth of new blood vessels and has already been approved for use in metastatic colorectal, breast, and kidney cancers as well as non-small cell lung cancer.

Tags: Avastin, brain cancer, chemotherapy drug, CPT-11, glioblastoma, lung cancer, steroid dose, steroids, vascular endothelial growth factor

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Squalamine, a chemical discovered from the liver of the sharks, has been proven to be highly effective in putting brakes on the formation of new blood vessels that are destined to feed brain cancer and tumors. This fact was confirmed by lab studies at the Johns Hopkins Medicine, Maryland.

The study revealed that Squalamine inhibits the growth of gliomas (brain cancers) that are implanted in the flanks of rats after disabling growth of blood vessel.

Henry Brem, M.D., director of neurosurgical oncology at Hopkins and senior author of the study, told that squalamine may prove to be an effective option for treating humans for curing brain tumor and other diseases that are dependent on new blood vessel growth.

In the lab tests, squalamine proved as effective as carmustine (chemotherapeutic agent) for slowing down the growth of gliomas. It also slowed down the growth of new blood vessels that was caused by tumors in the eyes of rabbits.

Tags: brain cancer, carmustine, chemotherapeutic agent, gliomas, squalamine

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