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Wednesday 23, Jun 2010

  Steroid concoction termed effective for patients with sinusitis

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Steroid concoction termed effective for patients with sinusitisA steroid nasal wash was termed as effective option for treating symptoms of chronic sinusitis without affecting adrenal gland function, as per a small US study. Budesonide, the nasal wash, is yet to get approval from the FDA for treating chronic sinusitis.

As per researchers from the Washington University School of Medicine in St. Louis, this is the first-of-its kind study evaluating safety of such a nasal wash.

Chronic Sinusitis afflicts up to 14 percent of population in the United States and is a continuing inflammation of the nose and sinuses behind it.

From Bio-Medicine.Org:

All participants reported at least some improvement in their sinusitis symptoms, and their adrenal gland function was not affected, the study found. The results were published in the March issue of Otolaryngology — Head & Neck Surgery.

“The clinical significance of this study is that budesonide nasal respules appear safe for short-term use for the relief of symptoms associated with chronic sinusitis,” the researchers concluded. “Budesonide respules seem to provide an effective treatment option for the patient with chronic rhinosinusitis with minimal fear of systemic adverse effects.”

Medical practitioners were advised by researchers to advise patients with sinusitis about the possible risks such as reduced bone mineral density that are linked with use of Budesonide in the long run.

Saturday 03, Apr 2010

  Sinusitis can be eased with steroid concoction

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Sinusitis can be eased with steroid concoctionA steroid nasal wash, Budesonide, could prove to be an effective option for minimizing the symptoms of chronic sinusitis without resulting in any effect on adrenal gland function.

This finding was disclosed by a small US study. The drug, however, is yet to get approval from the FDA for treating the complication.

It was remarked by researchers from the Washington University School of Medicine in St. Louis that this is the first-of-its-kind study examining the safety of a nasal wash.

From Bio-Medicine.Org:

All participants reported at least some improvement in their sinusitis symptoms, and their adrenal gland function was not affected, the study found. The results were published in the March issue of OtolaryngologyHead & Neck Surgery.

“The clinical significance of this study is that budesonide nasal respules appear safe for short-term use for the relief of symptoms associated with chronic sinusitis,” the researchers concluded. “Budesonide respules seem to provide an effective treatment option for the patient with chronic rhinosinusitis with minimal fear of systemic adverse effects.”

The researchers advised the doctors to communicate the risks associated with use of Budesonide such as decreased bone mineral density to the patients.

Thursday 07, Jan 2010

  New treatment for chronic sinusitis identified

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chronic-sinusitisA new treatment for chronic sinusitis has been identified by Summit Ear, Nose & Throat in an outpatient setting called FinESS™ Sinus Treatment.

FinESS can be classified as a new balloon sinuplasty technique, which is less invasive than the traditional sinus surgery. The technique breaks the cycle of chronic sinusitis with immediate relief to provide lasting results.

In this technique, a small balloon is inserted into the patient’s sinus passages. The balloon is inflated, deflated, and then removed.

From News-Medical.Net:

FinESS is effective and results in less pain, bleeding and recovery time for the patient and is performed in a relaxed outpatient setting. FinESS does not require the removal of delicate bone and sinus tissue and uses local anesthetic with or without light sedation. In most cases, patients are back to their normal routine within hours. Published clinical study results demonstrate that FinESS is an effective treatment that keeps treated sinuses open with significant quality of life improvements.

Gary Y. Shaw, MD, FACS of Summit Ear, Nose & Throat offers this innovative treatment for patients through two clinic locations in Lees Summit and Overland Park. “We are very excited to offer the FinESS balloon sinuplasty treatment as a new option for selected patients whose sinusitis symptoms persist or return despite antibiotics or nasal steroids, or who are looking for an effective minimally invasive alternative to traditional sinus surgery. Most procedures take 15 to 30 minutes and patients are able to return to normal activity almost immediately,” said Shaw.

This treatment option is considered by many members of the medical fraternity as a potential breakthrough for treating chronic sinusitis (CRS).

Tuesday 01, Dec 2009

  Novel therapy development for chronic sinusitis may be promoted by a new target

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Novel therapy development for chronic sinusitis may be promoted by a new targetAccording to researchers at the Johns Hopkins, a protein that is known to stimulate growth of blood vessel is responsible for the cell overgrowth in polyps’ development signifying one of the most severe forms of sinusitis.

It is considered by many scientists that this result finding will be more than helpful when it comes to developing novel therapies to treat this disease form that typically resists all current treatments.

From News-Medical.Net:

“This type of sinusitis isn’t subtle-you can spot the patients with polyps from across the room. They’re breathing through their mouths, they talk with nasal voices, they’re constantly sniffling, and their faces are swollen,” says Jean Kim, M.D., Ph.D., assistant professor in the Departments of Otolaryngology and Allergy and Clinical Immunology at the Johns Hopkins University School of Medicine, and a researcher at the Johns Hopkins Allergy and Asthma Center at the Johns Hopkins Bayview Medical Center.

Kim explains that surgery to remove the polyps is one of the most common treatments for this disease. However, nasal and sinus polyps in these patients almost always regrow. “Once the patient has entered the cycle of growing polyps, it’s very hard to get out,” she says. Another common treatment is oral steroids, but these drugs are fraught with many harmful side effects and also only temporarily treat the disease.

Chronic sinusitis is a common condition considered to affect approximately one out of every six people and can be classified as an ailment concerned with constant irritation and swelling of the nasal passages.

The findings suggest that medical practitioners could treat sinusitis in patients with polyps by making use of therapies that minimize VEGF (vascular endothelial growth factor) in sinus tissues.


Saturday 27, Jun 2009

  Steroid Nasal Wash effective for treating chronic sinusitis

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Steroid Nasal Wash effective for treating chronic sinusitisAccording to a small US Study, a steroid nasal wash can prove to be an effective option for reducing symptoms of chronic sinusitis without posing any harm to functions of the adrenal gland.

Chronic sinusitis is referred to as a continuing inflammation of the nose that is believed to affect approximately 14 percent of the United States’ population.

The researchers from the Washington University School of Medicine in St. Louis remarked that the study was the first one to conduct an examination about safety of this type of nasal wash. It was revealed in the study that the budesonide nasal respules are quite safe for a short-term usage to get relief from symptoms that are associated with chronic sinusitis.

From Bio-Medicine.Org:

The researchers, from Washington University School of Medicine in St. Louis, said it was the first study to examine the safety of this type of nasal wash, noting that suppression of adrenal gland function is a known complication of budesonide.

All participants reported at least some improvement in their sinusitis symptoms, and their adrenal gland function was not affected, the study found. The results were published in the March issue of Otolaryngology Head & Neck Surgery.

“The clinical significance of this study is that budesonide nasal respules appear safe for short-term use for the relief of symptoms associated with chronic sinusitis,” the researchers concluded. “Budesonide respules seem to provide an effective treatment option for the patient with chronic rhinosinusitis with minimal fear of systemic adverse effects.”

The U.S. Food and Drug Administration has not approved budesonide as a nasal wash, which means the nasal wash used in this study would be an off-label use of the drug. The researchers urged doctors to warn patients about the risks associated with long-term use of budesonide, including decreased bone mineral density.

All participants to the study showed some improvement with regard to the sinusitis symptoms. Furthermore, their adrenal gland was not affected by the usage of budesonide nasal respules.

Monday 15, Jun 2009

  Steroid Concoction can Ease Sinusitis

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Steroid Concoction can Ease SinusitisBudesonide, a steroid nasal wash, can help in minimizing the symptoms of chronic sinusitis without affecting functions of the adrenal gland, as per a small US Study.

Chronic Sinusitis refers to a continuing inflammation of the nose and sinuses behind it, which affects up to 14 percent of the US Population.

Researchers from the Washington University School of Medicine in St. Louis said that this study was the first to examine safety of such a nasal wash besides noting that suppression of the functions of the adrenal gland is a known complication of Budesonide.

From Bio-Medicine.Org:

All participants reported at least some improvement in their sinusitis symptoms, and their adrenal gland function was not affected, the study found. The results were published in the March issue of Otolaryngology Head & Neck Surgery.

“The clinical significance of this study is that budesonide nasal respules appear safe for short-term use for the relief of symptoms associated with chronic sinusitis,” the researchers concluded. “Budesonide respules seem to provide an effective treatment option for the patient with chronic rhinosinusitis with minimal fear of systemic adverse effects.”

The FDA has yet to approve Budesonide as a nasal wash. This means that the nasal wash of this study would be an off-label use of the drug.

In the meanwhile, researchers advised doctors to advise patients about the risks associated with long-term use of Budesonide such as decreased bone mineral density.

Wednesday 27, May 2009

  Steroid Nasal Wash Provides Short-Term Relief For Sinusitis

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Steroid Nasal Wash Provides Short-Term Relief For SinusitisA study showed that a steroid nasal wash can help lessen the symptoms of chronic sinusitis without affecting the adrenal gland function.

The study was participated by nine patients who were administered with a steroid nasal wash which is composed of 0.25 milligrams of the corticosteroid budesonide and 5 milliliters of saline, in each nostril once a day for 30 days.

From Health:

Chronic sinusitis is a persistent inflammation of the nose and sinuses behind the nose that affects up to 14 percent of people in the United States, according to background information in the study.

The study included nine people who were told to use a nasal wash, composed of 0.25 milligrams of the corticosteroid budesonide and 5 milliliters of saline, in each nostril once a day for 30 days. The budesonide came in respules — small, plastic, liquid-containing devices.

The researchers, from Washington University School of Medicine in St. Louis, said it was the first study to examine the safety of this type of nasal wash, noting that suppression of adrenal gland function is a known complication of budesonide.

“The clinical significance of this study is that budesonide nasal respules appear safe for short-term use for the relief of symptoms associated with chronic sinusitis,” the researchers concluded.

The U.S. Food and Drug Administration has not approved budesonide as a nasal wash, which means the nasal wash used in this study would be an off-label use of the drug. The researchers urged doctors to warn patients about the risks associated with long-term use of budesonide, including decreased bone mineral density.

The study revealed that budesonide nasal respules are safe for short-term use for the relief of symptoms associated with chronic sinusitis. Since budesonide nasal wash is not yet approved by the U.S FDA, the researchers suggested that doctors must discuss the long-term risks of using budesonide respules.