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Saturday 31, Dec 2011

  Diabetes risk increase with inhaled steroids

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Inhaling corticosteroids can elevate chances of being diagnosed with type 2 diabetes, according to investigators from the Jewish General Hospital’s Lady Davis Institute for Medical Research (LDI) in Montreal.

The investigators’ findings suggested that asthmatics and those suffering from chronic obstructive pulmonary disorder (COPD) taking corticosteroids may be at a considerable risk.

The study was published in the American Journal of Medicine.

Tuesday 22, Feb 2011

  Morbidity and mortality of severe bacterial pneumonia reduced by steroids

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Morbidity and mortality of severe bacterial pneumonia reduced by steroidsThe use of corticosteroids is effective for reducing the morbidity and mortality of severe bacterial pneumonia, Dr. Antoni Torres said at the 12th International Congress on Infectious Diseases.

The finding was supported by results from two positive randomized trials, multiple observational studies, and animal models.

The first randomized trial was a multicenter, double-blind, Italian study involving 46 patients with severe CAP on placebo or 200 mg of hydrocortisone as an IV bolus, followed by 7 days of therapy at 10 mg/hour.

Sunday 06, Feb 2011

  Exacerbation rate in COPD reduced by Roflumilast

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Exacerbation rate in COPD reduced by RoflumilastIn a large 12-month randomized trial, Roflumilast was found effective for improving lung function and prevent exacerbations in patients with COPD with chronic bronchitis and severe airflow obstruction.

Dr. Andrew McIvor said at the annual meeting of the American College of Chest Physicians that results of the 1,568-patient, double-blind, placebo-controlled study known as the M2-125 trial indicate that roflumilast is an important potential advance in the treatment of a subset of patients with COPD.

Dr. McIvor of St. Joseph’s Healthcare Hamilton (Ont.) explained that Roflumilast (Daxas) is an investigational selective phosphodiesterase 4 inhibitor that can target the inflammation that is a hallmark of the disease when taken daily in an oral form.

Thursday 25, Nov 2010

  COPD management with steroids leads to reduced mortality rate

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COPD management with steroids leads to reduced mortality rateSignificant reductions in mortality rate can be noticed in COPD (chronic obstructive pulmonary disease) patients when inhaled corticosteroids are used.

This finding was disclosed by a study appearing in an issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians (ACCP).

It was reported by this study that individuals making use of steroids paired with beta-agonists demonstrated a fall in cardiovascular-related death alone by 38 percent.

Friday 20, Aug 2010

  Reduced mortality rate seen with steroids for COPD management

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Reduced mortality rate seen with steroids for COPD managementAccording to a study appearing in an issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians (ACCP), mortality rate can be significantly reduced in COPD (chronic obstructive pulmonary disease) patients when inhaled corticosteroids are used.

The study reported that patients making use of steroids paired with beta-agonists experienced a fall in cardiovascular-related death alone by 38 percent.

W. Michael Alberts, MD, FCCP, President of the ACCP, said the study findings are intriguing for clinicians and suggest the need of future research for defining the roles and mechanisms of the effect of inhaled steroids on both cardiovascular and respiratory mortality.

Monday 16, Aug 2010

  Potential treatment for Smoker’s lung

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Potential treatment for Smoker's lungA potential form of treatment in context of one of the most common and fatal diseases in the UK – smokers lung – is about to be identified by scientists from the Imperial College, London that can solve problems in treatment with steroids.

Chronic Obstructive Pulmonary Disease (COPD) – chronic bronchitis and emphysema, or ‘smoker’s lung’, is considered to affect approximately 6 percent of population in the United Kingdom.

It was discovered by Professor Peter Barnes and his colleagues that steroids play the role of molecular bridges for recruiting HDAC2 in the context of respective genes where they can be made to switch off.

Friday 30, Jul 2010

  COPD patients could benefit with steroids

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COPD patients could benefit with steroidsReduced mortality risk can be noticed in patients afflicted with chronic obstructive pulmonary disease (COPD) when they are treated with inhaled steroids.

It was remarked by Christine Macie, MD, FCCP, Cambridge Hospital, Ontario, Canada and author of the study that patients on steroids are relatively better protected than those not making use of them.

Dr. Macie also remarked that inhaled corticosteroids could be highly effective to prolong lives of patients with COPD.

Tuesday 27, Jul 2010

  Johns Hopkins experts made call for extra caution

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Johns Hopkins experts made call for extra cautionAccording to Lung disease experts at Johns Hopkins, physicians treating their patients afflicted with COPD (chronic obstructive pulmonary disease) need to observe extra caution while dealing with them.

It was remarked by lead author and pulmonologist M. Brad Drummond, M.D., M.H.S. that this finding has implications and serves a reminder to COPD patients so that they could take necessary preventive steps for avoiding pneumonia, which doubles their risk of death.

As many as 11 million Americans are afflicted with COPD every year and a big majority of this population belongs to the category of past or present-day smokers.

Monday 26, Jul 2010

  Treatment involving inhaled steroids useful for COPD management

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Treatment involving inhaled steroids useful for COPD managementChronic obstructive pulmonary disease (COPD), which is one of the five leading causes of death worldwide, is characterized by an inflammatory response to inhaled fumes such as tobacco smoke that results in breath shortness, limited airflow, and loss of lung function.

Fluticasone propionate, which is an inhaled steroid, could minimize the ability of major pathogens for invading the respiratory epithelium, as per a study by Sebastian Albertí (Institut Universitari d’Investigacions en Ciències de la Salut, IUNICS, Palma de Mallorca, Spain) and colleagues.

Findings of the study are expected to provide implications to physicians all over the world when it comes to treating COPD patients.

Sunday 18, Jul 2010

  Inhaled steroids effective for treating COPD

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COPD treatment is facilitated with inhaled steroidsPatients afflicted with chronic obstructive pulmonary disease or COPD can be effectively treated and experienced reduced mortality risk when treated with inhaled corticosteroids, as per a study appearing in the CHEST, which is a peer-reviewed journal of the American College of Chest Physicians (ACCP).

COPD patients who make use of inhaled corticosteroids benefit from improved survival rates as per Christine Macie, MD, FCCP, Cambridge Hospital, Ontario, Canada and author of this study.

COPD patients administered with inhaled steroids are relatively in a better position than those not using it, as per Dr. Macie. It was also revealed in the study that cardiovascular related deaths were reduced by as much as 38% and a 25% reduced all-cause mortality rate was noticed among patients administered with inhaled corticosteroids within thirty days of discharge from the hospital.

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