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Sunday 28, Feb 2016

  Orica-GreenEdge And Katusha Leave MPCC

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Australian professional road race cycling team Orica–GreenEDGE and Russian road bicycle racing team Katusha have decided to leave the Movement for a Credible Cycling (MPCC) because they now believe rules of the UCI are enough.

Orica-GreenEdge and Katusha became the latest teams to have left the MPCC after the exit of LottoNL – Jumbo and Lampre – Merida. LottoNL and Lampre left MPCC after its riders were blocked from racing under rules of the France-based voluntary organization. American Chris Horner, who was previously with Lampre, was unable to defend his Vuelta a España title in 2014 because of low cortisol levels and the same was experienced by LottoNL’s George Bennett during last year’s Giro d’Italia. Previously, the Astana team ignored the cortisol rules of MPCC ahead of the 2014 Tour de France in allowing Lars Boom to race and Astana was later expelled from the organization. The same thing happened with Bardiani-CSF team at the 2015 Giro d’Italia and also left the MPCC.

The problem of overlapping rules was acknowledged by UCI president Brian Cookson who remarked the only rules teams should have to worry about are those of the world governing body of cycling, the UCI.

In a press release, Orica’s general manager Shayne Bannan said we would like to thank all the current and former members of the MPCC for the discussions and initiatives and for sincerely helping the sport move further in the right direction. Bannan added we fully support the initiatives that have now become an integrated part of the rules of the sport. Going onwards, we will be a strong supporter of seeing these and other initiatives being further developed by the official organizations in collaboration with all the other teams and stakeholders of cycling.

In a statement, Team Katusha said Team Katusha understands that the MPCC intends to strictly apply its rule regardless of the similar UCI provision recently adopted, despite a clear decision taken in this case by the UCI Disciplinary Commission and without acknowledging the specificity of the present case. Team Katusha statement further reads that it regrets the position of the MPCC and in particular its refusal to adapt its rules to the mandatory UCI Regulations and as a consequence Team Katusha has no other choice but to leave the MPCC with immediate effect. Team Katusha also said it would like to underline that it continues to fight against doping by every possible means as it has done in the past years. In this respect, Team Katusha will continue to voluntarily apply other MPCC rules – such as the prohibition to use Tramadol or the imposition of several rest days for a rider in the event of collapsing cortisol levels.

The MPCC, without Orica and Katusha, count only seven of the 18 WorldTour teams as members: Ag2r La Mondiale, Cannondale, Dimension Data, FDJ, Giant – Alpecin, IAM Cycling, and Lotto – Soudal. Teams like Astana, Etixx – Quick-Step, Lampre, LottoNL, Movistar, Sky, Tinkoff, and U.S.-registered teams BMC Racing and Trek-Segafredo are not members of the MPCC.

The MPCC existed for some time and gained momentum after the Lance Armstrong doping scandal. Many teams signed up to its stricter rules for increasing the stance of professional cycling against doping and controversial teams.

pdf_iconDownload in PDF: Orica-GreenEdge And Katusha Leave MPCC

Monday 07, Sep 2015

  Team Astana Thrown Out Of MPCC Over Doping Issues

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The Movement for Credible Cycling has thrown out the Astana Cycling team after the professional road bicycle racing team sponsored by the Samruk-Kazyna failed to comply with strict anti-doping rules of the association at this year’s Tour de France.

In a statement on Friday, the MPCC said the board of directors of MPCC after hearing Team Astana representative Dmitriy Fofonov’s arguments have decided to exclude Team Astana for non-compliance with article 9 of the regulations. The MPCC statement added although cortisol hormones are an allowed medicine when prescribed by a physician, the use of that medicine has frequently been abused in the history of sports [including in cycling] for the purpose of increasing the performance. It was also added in the statement that a low level of cortisol can potentially endanger the health of athletes in certain circumstances. The MPCC statement also reads that MPCC and its member teams for both reasons and with the objective to contribute to restoring the credibility of cycling have introduced that voluntary norm below which its riders will temporarily withdraw from competition.

In July, Astana rider Lars Boom started the Tour despite showing low levels of cortisone in a test conducted on the eve of the race. Low cortisol levels can be explained by the use of corticoids, anti-inflammatory drugs that are allowed out of competition but forbidden while racing unless a therapeutic use exemption is granted beforehand to a rider. Under MPCC rules, Boom should have rested for eight days but UCI regulations did not forbid him from racing. Boom later withdrew ahead of stage 10 due to illness.

Team Astana defended Boom by remarking the cortisol reading was as a result of “a long-standing and well-known application of anti-asthma therapy by the athlete.” Team Astana tried to substitute Boom with another rider after the issue arose but the world governing body of cycling remarked it was too late for changes to the roster.

Commenting on the issue of Lars Boom, UCI President Brian Cookson had said Lars Boom has not broken any UCI or WADA rules, the issue of cortisol and cortisone has been referred to WADA’s scientific experts and at the present moment they have not recommended us or anyone else take action to include that within our rules.

Earlier this year, Team Astana managed to retain its WorldTour license for 2015 despite many of its riders failing to clear anti-doping tests. Kazakh brothers Maxim and Valentin Iglinsky tested positive for the banned blood booster EPO. To add to the problems, three riders on the secondary Continental Tour team failed tests for anabolic androgenic steroids.

In another development, MPCC said it had heard Androni Giocattoli‘s case and added that it heard manager Gianni Savio’s arguments on the three positive cases in the past 16 months and added the squad had acted appropriately after the recent cases emerged. In June 2015, Patrick Facchini tested positive for Tuaminoheptane and the positive test of Fabio Taborre for FG-4592 came in last June and Davide Appollonio’s positive for EPO in the same month.

pdf_iconDownload in PDF: Team Astana Thrown Out Of MPCC Over Doping Issues

Tuesday 07, May 2013

  Two-Year Suspensions For Cyclist And Track & Field Athlete

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Two-Year Suspensions For Cyclist And Track & Field Athlete

Yosmani Pol Rodriguez of Weston, an athlete in the sport of cycling, has tested positive for a prohibited substance, according to an announcement by the United States Anti-Doping Agency.

The 32-year-old has accepted a two-year sanction for his doping offense after testing positive for Dexamethasone as the result of an in-competition urine sample collected on March 10, 2012 at the Delray Beach Twilight Criterium. Dexamethasone is classified as a glucocorticosteroid on the World Anti-Doping Prohibited List and is prohibited under the USADA Protocol for Olympic and Paralympic Movement Testing and the International Cycling Union (“UCI”) anti-doping rules, both of which have adopted the World Anti-Doping Code (“Code”) and the World Anti-Doping Agency Prohibited List. The cyclist accepted a two-year period of ineligibility, which began on September 2, 2012, the date of his last competition. Rodriguez has also been disqualified from all competitive results achieved on and subsequent to March 10, 2012, including the forfeiture of any medals, points and prizes.

A potent synthetic member of the glucocorticoid class of steroid drugs, Dexamethasone can suppress the natural pituitary-adrenal axis and acts as an anti-inflammatory and immunosuppressant and is medically prescribed to treat inflammatory conditions such as allergies, skin conditions, ulcerative colitis, arthritis, and breathing disorders. When taken orally, Dexamethasone is 26.6 times more potent than the naturally occurring hormone cortisol and 6.6 times more potent than prednisone. The CYP2D6 enzyme inducer is commonly used by sportsmen to develop fat easily and may increase the effects of many prodrugs and protoxins which are metabolized via CYP2D6 (like tramadol or codeine) by directly increasing the amount of the active metabolite produced.

In another development, Shawn Crawford of Culver City, an athlete in the sport of track & field, has received a suspension of two years for committing an anti-doping rule violation in which he failed to file his whereabouts information. The 35-year-old Crawford was a member of the USADA National Testing Pool from 2001 through the beginning of 2013, which consists of a select group of athletes subject to certain whereabouts requirements in order to be located for USADA Out-of-Competition testing.

The track and field athlete failed to comply with the whereabouts requirements and, as a result, accrued three Whereabouts Failures within an 18-month period. Under the USADA Protocol for Olympic and Paralympic Movement Testing and the International Association of Athletics Federations (IAAF) Anti-Doping Rules, both of which have adopted the World Anti-Doping Code (“Code”), the combination of three Whereabouts Failures within an 18-month period constitutes a rule violation. A Whereabouts Failure for National Testing Pool athletes includes failure to provide required quarterly whereabouts filings and/or failure to be available for testing due to inaccurate or incomplete information provided by the athlete. The two-year period of ineligibility for Crawford, began on April 17, 2013, the date he received the sanction. As a result of the violation, Crawford has been disqualified from all competitive results achieved on and subsequent to November 17, 2012 the date of his third Whereabouts Failure, including forfeiture of any medals, points, and prizes.

pdf_iconDownload in PDF: Two-Year Suspensions For Cyclist And Track & Field Athlete

Monday 03, Jan 2011

  Gene activity is influenced by steroid hormones

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Gene activity is influenced by steroid hormonesScientists at the University of Bristol and the National Cancer Institute (NCI), USA have revealed that the manner in which gene expression takes place in rodents is affected by intermittent signaling by steroid hormones.

This finding is considered to have critical implications to understand how steroids work and how they can assist in opening up novel avenues for development of new therapies.

The research appeared online and appeared in the September 2009 issue of Nature Cell Biology.

Friday 20, Aug 2010

  Dutch researchers find stress delays puberty

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Dutch researchers find stress delays pubertyDevelopment of genital organs of carp can be delayed when subjected to stress in such a manner that puberty is delayed, according to NWO research at Utrecht University. It is believed that cortisol, the stress hormone, plays an important role in delaying puberty.

It was assumed by the researchers that the stress hormone is responsibly for causing delays in puberty.

The finding is expected to have implications for medical practitioners in this segment.

Monday 28, Jun 2010

  Steroid hormones have influence on activity of genes

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Steroid hormones have influence on activity of genesThe manner in which genes are expressed in rodents is affected by intermittent signaling by steroid hormones, according to a research by scientists at the University of Bristol and the National Cancer Institute (NCI), USA.

The research appeared online and appeared in the September 2009 issue of Nature Cell Biology.

The finding is expected to have implications for understanding how steroids work and can help in opening up novel avenues for development of new therapies.

Thursday 27, May 2010

  Zebrafish finds a new role in human studies

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Zebrafish finds a new role in human studiesZebrafish, an important animal model in disease and environmental studies, can offer the means for helping scientists eventually disclose the function of a mysterious enzyme linked to the steroid cortisol, and found in the human brain.

Steroids such as cortisol perform a variety of duties like bone formation, brain activity, and immune response regulation in humans and other vertebrates.

Baker was able to find that genomes of mice and rats do not contain 11 beta-HSD3 that suggest that inserting the appropriate gene for the enzyme in these animal models may result in additional investigation avenues.

Friday 23, Apr 2010

  Fight against parasitic disease supported by worm hormone

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Fight against parasitic disease supported by worm hormoneHormone-like molecules in tiny worms called nematodes, on a biochemical level, works similarly to the way in which specific hormones work in humans, as per a new research at UT Southwestern Medical Center. It is believed that this finding would one day help in eradicating worm infections that tend to affect a third of world’s population.

A new molecule that activates gene involved in development and reproduction of Caenorhabditis elegans, a common research worm about the size of a pinhead, was discovered by researchers at the UT Southwestern.

The research was funded by HHMI, the Welch Foundation, the National Institutes of Health, the Jay and Betty Van Andel Foundation, the Department of Defense and the Glenn/AFAR Breakthroughs in Gerontology.

Monday 15, Mar 2010

  Gene activity found influenced by steroid hormones

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Gene activity found influenced by steroid hormonesA research by scientists at the University of Bristol and the National Cancer Institute (NCI), USA has suggested that intermittent signaling by steroid hormones has the potential of affecting the manner by which genes are expressed in rodents.

This finding is expected to provide significant implications to understand how steroids operate and open up novel avenues for new therapies.

The findings were published online and appeared in the September 2009 issue of Nature Cell Biology.

Thursday 25, Feb 2010

  Oral contraceptives damage muscle gains in young women

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oral-contraceptives-damage-muscle-gains-in-young-womenThe effect of oral contraceptives (OC) on the body composition and exercise performance of young women using them was not studied in detail till now but now it has been found that such a use can impair muscle gains and is associated with low hormone levels.

The findings were disclosed in a study entitled Oral Contraceptive Use Impairs Muscle Gains in Young Women.

The study was conducted by Chang-Woock Lee and Steven E. Riechman, Department of Health and Kinesiology, Texas A&M University, College Station, TX; and Mark A. Newman, Human Energy Research Laboratory, University of Pittsburgh, Pittsburgh, PA.

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