A new drug compound has been identified by the researchers at the University of Southern California and according to them the drug appears to target tumor cells and surrounding blood vessels without showing any negative side effect usually associated with Cox-2 inhibitors.

As per the data presented at the AACR 100th Annual Meeting 2009, the compound named 2.5-dimethyl-celecoxib (DMC) would have a strong anti-tumor effect even while attacking the vasculature that provides the blood supply necessary for tumor growth.

Florence M. Hofman, professor of pathology at the Keck School of Medicine of USC, said “If left behind, the blood vessels within the tumor will help the tumor cells to survive and re-grow.” He further added that they believed that DMC might prove useful in the treatment of brain tumors, such as gliomas, which are highly vascular and also appeared to be a promising long-term treatment as it did not have the negative cardiovascular effects typically associated with Cox-2 inhibitors.

Hofman explained that Cox-2 inhibitors are most commonly used as anti-inflammatory drugs and have been effective in treating certain kinds of cancer. However, its long-term use can cause increased risk of heart attack and stroke while DMS mainatins its anti-tumor activity without inhibiting action of Cox-2.

From Science Daily:

Researchers at the University of Southern California have identified a new drug compound that appears to target tumor cells and surrounding blood vessels without the negative side effects typically associated with Cox-2 inhibitors.

The compound 2.5-dimethyl-celecoxib (DMC) appears to have a strong anti-tumor effect while also attacking the vasculature that provides the blood supply necessary for tumor growth, according to data presented at the AACR 100th Annual Meeting 2009. The findings were presented on April 19.

“If left behind, the blood vessels within the tumor will help the tumor cells to survive and re-grow,” says Florence M. Hofman, Ph.D., professor of pathology at the Keck School of Medicine of USC. “We believe that DMC will be particularly useful for treating brain tumors such as gliomas, which are highly vascular.

The study focused on testing the effectiveness of the DMC compound by isolating endothelial cells, which lines the interior surface of blood vessels, from human nonmalignant brain and glioma tissues and treating them with DMC.

In the study, the researchers found that the drug was not only cytotoxic to tumor-associated endothelial cells, but also suppressed cell proliferation process and migration occurrence without having toxic effects on normal tissues.

Hofman concluded with the saying that though their research focused mainly on brain tumors, but they believed that the drug might work for several different tumors that are dependent on blood vessels. However, further research would help them in understanding its full potential.

Tags: anti-inflammatory drugs, Cox-2 inhibitors, dimethyl-celecoxib

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