Corticosteroids are highly effective for providing relief to patients suffering from Duchenne Muscular Dystrophy (DMD), according to a practice guideline published in the Neurology, the scientific journal of the American Academy of Neurology.

Richard T. Moxley III, MD, of the University of Rochester in Rochester, N.Y. and lead author, said improvements in children affected with DMD are best seen with corticosteroids.

From News.Bio-Medicine.Org:

The guideline authors reviewed all available research for the use of corticosteroids in the treatment of Duchenne muscular dystrophy. Corticosteroids are man-made drugs that are similar to the body’s hormone cortisone. Two corticosteroids, prednisone and deflazacort, were found to slow the rate of muscle deterioration, and are recommended as potential treatments to minimize the effect of Duchenne muscular dystrophy.

Prednisone was found to help muscle strength and function and should be offered as a treatment option. Deflazacort, a drug similar to prednisone, is also recommended as a treatment option but is not available in the United States at this time.

“Corticosteroids are the only effective drugs in providing improvements in children with Duchenne muscular dystrophy,” said lead author Richard T. Moxley III, MD, of the University of Rochester in Rochester, N.Y.

Prednisone and Deflazacort, two corticosteroids, were recommended for children with DMD since they can slow down the muscle deterioration rate in aim to reduce the effect of DMD.

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Corticosteroids are effective to treat patients with Duchenne muscular dystrophy (DMD), according to a new practice guideline published in the Neurology, the scientific journal of the American Academy of Neurology.

Richard T. Moxley III, MD, of the University of Rochester in Rochester, N.Y. and lead author, said that corticosteroids are the only effective drugs for ensuring improvements in children with DMD.

Two corticosteroids, prednisone and deflazacort, were recommended as prospective treatment methodologies since they slow down muscle deterioration rate for reducing the effects of DMD.

From News.Bio-Medicine.Org:

The guideline authors reviewed all available research for the use of corticosteroids in the treatment of Duchenne muscular dystrophy. Corticosteroids are man-made drugs that are similar to the body’s hormone cortisone. Two corticosteroids, prednisone and deflazacort, were found to slow the rate of muscle deterioration, and are recommended as potential treatments to minimize the effect of Duchenne muscular dystrophy.

Prednisone was found to help muscle strength and function and should be offered as a treatment option. Deflazacort, a drug similar to prednisone, is also recommended as a treatment option but is not available in the United States at this time.

“Corticosteroids are the only effective drugs in providing improvements in children with Duchenne muscular dystrophy,” said lead author Richard T. Moxley III, MD, of the University of Rochester in Rochester, N.Y.

It was, however, remarked that pros and cons of corticosteroid treatment must be analyzed in detail so that a result-oriented and safe treatment methodology can be developed.

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When it comes to treating patients with Duchenne Muscular Dystrophy (DMD), there could be nothing better and more effective than corticosteroids that are recommended as a first-line therapy for DMD.

This finding appeared in a new practice guideline published in the Neurology, the scientific journal of the American Academy of Neurology.

Richard T. Moxley III, MD, of the University of Rochester in Rochester, N.Y. and lead author, said that corticosteroids can be termed as the only effective drugs for providing relief to children with DMD.

From News.Bio-Medicine.Org:

The guideline authors reviewed all available research for the use of corticosteroids in the treatment of Duchenne muscular dystrophy. Corticosteroids are man-made drugs that are similar to the body’s hormone cortisone. Two corticosteroids, prednisone and deflazacort, were found to slow the rate of muscle deterioration, and are recommended as potential treatments to minimize the effect of Duchenne muscular dystrophy.

Prednisone was found to help muscle strength and function and should be offered as a treatment option. Deflazacort, a drug similar to prednisone, is also recommended as a treatment option but is not available in the United States at this time.

“Corticosteroids are the only effective drugs in providing improvements in children with Duchenne muscular dystrophy,” said lead author Richard T. Moxley III, MD, of the University of Rochester in Rochester, N.Y.

It was found out that two corticosteroids, prednisone and deflazacort, are exemplary to be recommended as potential treatment options as they have the unique ability of slowing down the rate of muscle deterioration leading to reduced effects of DMD.

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Boys suffering with Duchenne muscular dystrophy (DMD) can walk for long on their own and for long periods of time besides reducing the risk of scoliosis when administered with a daily steroid treatment on a continuing basis.

This finding was presented in a study published in the May 8, 2007, issue of Neurology®, the scientific journal of the American Academy of Neurology.

From News-Medical.Net:

“Previous studies have shown steroids improve strength and function in Duchenne muscular dystrophy, but this is the first study to show the long-term impact and how treated boys are able to walk longer on their own,” said study author Wendy King, PT, with the Department of Neurology at Ohio State University Medical Center, and member of the American Academy of Neurology.

However, the study found those boys being treated with daily steroids had an increased risk of vertebral and leg fractures. Vertebral fractures occurred in 32 percent of the boys treated with steroids, whereas there were no fractures reported in the untreated group. Leg fractures were 2.6 times more common in the steroid-treated group. King said this may be due to increased body weight and that the treated boys walked longer than the untreated group.

“The benefits of steroids come at a cost of the side effects, and patients and parents need to weigh the benefits and risk of steroid treatments in order to make an informed decision,” said King.

Duchenne muscular dystrophy is a complication that happens to one in every 3,500 boys and does not have any cure till now.

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Boys with Duchenne muscular dystrophy (MD) can expect to walk for long and without any assistance when treated with a daily administration of steroids, as per study supported by the General Clinical Research Center at the Ohio State University and the National Center of Research Resources of NIH.

Wendy King, a physical therapist in the neurology department at Ohio State University, was of the view that scoliosis and curvature degree risks are reduced to significant extents with daily administration of corticosteroids, which improve function and strength in boys with X-linked recessive ailment.

From Medpagetoday.com:

The reason for non-treatment with steroids was invariably parent refusal because of fear of side effects, the researchers said. The average duration of steroid use was 8.04 years.

The study found:

* Boys on steroids were able to walk independently, on average, 3.3 years longer than those who weren’t treated. The difference — from 9.21 years to 12.52 years — was significant at P<0.0001.

* The prevalence of scoliosis in the treated boys was 31%, compared with 91% among those not getting steroids, a difference that was significant at P<0.0001.

* The average scoliotic curve was 11.6 degrees in the treated boys, compared with 33.2 degrees in the untreated boys, which was also significant at P<0.0001.

* On the other hand, 32% of the treated boys had vertebral compression fractures versus none in those not getting steroids, which was significant at P<0.0012.

* The yearly long-bone fracture rate was 0.088 among the treated boys, but only 0.033 in the untreated group, difference by a factor of 2.6, which was significant at P<0.0032.

Several factors probably play a role in the increased rate of long-bone fractures, the researchers said, including prolonged independent walking and increased body weight because of the steroids.

It was also remarked that patients with Duchenne muscular dystrophy must be given calcium supplements along with regular care in the form of bone density examinations at intervals of 1/2 month to 2 years because of orthopedic implications of steroids use.

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As per results of a recently concluded study, boys with Duchenne muscular dystrophy can walk for longer on their own after getting themselves treated with daily steroid treatment. It was also remarked during the study that steroid treatment can help them reduce the risk of scoliosis to a significant extent.

The results were part of a published study in an issue of Neurology, the scientific journal of the American Academy of Neurology.

From News-Medical.Net:

For the study, researchers reviewed records of 143 boys seen at the Ohio State University Muscular Dystrophy Clinic in Columbus. Of the group, 75 had been treated with corticosteroids for an average of eight years and the rest of the boys had never been treated or had received a brief dose of steroids.

The study found boys who were treated with daily steroids walked by themselves 3.3 years longer than the untreated boys and had a lower rate of scoliosis, 31 percent compared to 91 percent.

“Previous studies have shown steroids improve strength and function in Duchenne muscular dystrophy, but this is the first study to show the long-term impact and how treated boys are able to walk longer on their own,” said study author Wendy King, PT, with the Department of Neurology at Ohio State University Medical Center, and member of the American Academy of Neurology.

However, it was remarked that benefits of steroid treatment for boys with muscular dystrophy may come at the cost of some side effects and doctors must be highly careful while advising steroid treatment.

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Corticosteroids can be considered as a first-line therapy for treating Duchenne Muscular Dystrophy (DMD), according to a new practice guideline published in the Neurology, the scientific journal of the American Academy of Neurology. It was suggested during the study that patients suffering from the ailment can experience great relief when corticosteroids are administered to them.

Two corticosteroids, prednisone and deflazacort, were recommended as potential treatment methodologies, as they have the unique ability to slowdown the rate of muscle deterioration leading to reduced effects of DMD.

Richard T. Moxley III, MD, of the University of Rochester in Rochester, N.Y. and lead author, said that corticosteroids are the only effective drugs for providing improvements in children with DMD.

From News.Bio-Medicine.Org:

The guideline authors reviewed all available research for the use of corticosteroids in the treatment of Duchenne muscular dystrophy. Corticosteroids are man-made drugs that are similar to the body’s hormone cortisone. Two corticosteroids, prednisone and deflazacort, were found to slow the rate of muscle deterioration, and are recommended as potential treatments to minimize the effect of Duchenne muscular dystrophy.

Prednisone was found to help muscle strength and function and should be offered as a treatment option. Deflazacort, a drug similar to prednisone, is also recommended as a treatment option but is not available in the United States at this time.

“Corticosteroids are the only effective drugs in providing improvements in children with Duchenne muscular dystrophy,” said lead author Richard T. Moxley III, MD, of the University of Rochester in Rochester, N.Y.

It was however remarked that pros and cons of steroid treatment must be evaluated carefully so that complete benefits can be attained.

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Boys with Duchenne muscular dystrophy who were previously unable to walk on their own for long can now have a sigh of relief. According to a recent study, daily steroid treatment allows them to walk on their own and minimize the risk of scoliosis to a considerable extent.

The results were part of a study that was published in the May 8, 2007, issue of Neurology, the scientific journal of the American Academy of Neurology.

From News-Medical.Net:

For the study, researchers reviewed records of 143 boys seen at the Ohio State University Muscular Dystrophy Clinic in Columbus. Of the group, 75 had been treated with corticosteroids for an average of eight years and the rest of the boys had never been treated or had received a brief dose of steroids.

The study found boys who were treated with daily steroids walked by themselves 3.3 years longer than the untreated boys and had a lower rate of scoliosis, 31 percent compared to 91 percent.

“Previous studies have shown steroids improve strength and function in Duchenne muscular dystrophy, but this is the first study to show the long-term impact and how treated boys are able to walk longer on their own,” said study author Wendy King, PT, with the Department of Neurology at Ohio State University Medical Center, and member of the American Academy of Neurology.

It was remarked that the benefits of steroids come at a cost of side effects and it is best to weigh the benefits and risk of steroid treatments before making any decision. The study is expected to bring smiles on the faces of patients and parents of these patients who have been long expecting a cure for this disorder.

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As per a new practice guideline published in the Neurology, the scientific journal of the American Academy of Neurology, corticosteroids may be beneficial in treating patients with Duchenne muscular dystrophy. It was also remarked that the corticosteroids can also be used effectively as a treatment option to help those suffering from Duchenne Muscular Dystrophy (DMD).

Richard T. Moxley III, MD, of the University of Rochester in Rochester, N.Y. and lead author, remarked that Corticosteroids are considered to be the only effective drugs when it comes to providing improvements in children with DMD.

Two corticosteroids, Prednisone and Deflazacort, were recommended as potential treatment methodologies as they tend to slowdown the rate of muscle deterioration when it comes to minimizing the effect of DMD.

From News.Bio-Medicine.Org:

The guideline authors reviewed all available research for the use of corticosteroids in the treatment of Duchenne muscular dystrophy. Corticosteroids are man-made drugs that are similar to the body’s hormone cortisone. Two corticosteroids, prednisone and deflazacort, were found to slow the rate of muscle deterioration, and are recommended as potential treatments to minimize the effect of Duchenne muscular dystrophy.

Prednisone was found to help muscle strength and function and should be offered as a treatment option. Deflazacort, a drug similar to prednisone, is also recommended as a treatment option but is not available in the United States at this time.

“Corticosteroids are the only effective drugs in providing improvements in children with Duchenne muscular dystrophy,” said lead author Richard T. Moxley III, MD, of the University of Rochester in Rochester, N.Y.

It was remarked that the pros and cons of treatment with corticosteroids should be analyzed so that an effective treatment methodology can be developed. If the side-effects outweigh the benefits, then it is recommended to reduce the drug dosage.

Duchenne muscular dystrophy is a genetic disorder that is linked to the X-chromosome and is considered to be the most common form of muscular dystrophy in young children. It causes a gradual muscle breakdown and decline in muscle power; it mainly affects boys.

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In a study that was supported by the General Clinical Research Center at the Ohio State University and the National Center of Research Resources of NIH, it was revealed that boys with Duchenne muscular dystrophy (MD) are able to walk more than 3 years longer when they take corticosteroids on a daily basis.

Wendy King, a physical therapist in the neurology department at Ohio State University, remarked that the risk of scoliosis along with the degree of curvature gets sharply reduced with daily doses of corticosteroids.

King remarked that this study is the first to look at the long-term impact of the drugs against previous studies that merely showed that corticosteroids can improve strength and function in boys with X-linked recessive ailment.

From Medpagetoday.com:

The reason for non-treatment with steroids was invariably parent refusal because of fear of side effects, the researchers said. The average duration of steroid use was 8.04 years.

The study found:

Boys on steroids were able to walk independently, on average, 3.3 years longer than those who weren’t treated. The difference — from 9.21 years to 12.52 years — was significant at P<0.0001.

The prevalence of scoliosis in the treated boys was 31%, compared with 91% among those not getting steroids, a difference that was significant at P<0.0001.

The average scoliotic curve was 11.6 degrees in the treated boys, compared with 33.2 degrees in the untreated boys, which was also significant at P<0.0001.

On the other hand, 32% of the treated boys had vertebral compression fractures versus none in those not getting steroids, which was significant at P<0.0012.

The yearly long-bone fracture rate was 0.088 among the treated boys, but only 0.033 in the untreated group, difference by a factor of 2.6, which was significant at P<0.0032.

Several factors probably play a role in the increased rate of long-bone fractures, the researchers said, including prolonged independent walking and increased body weight because of the steroids.

The study also suggested that patients with Duchenne MD must be prescribed calcium supplements and provided with regular bone density examinations at intervals of six months to twenty four months because of the orthopedic implications of usage of steroids.

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