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Thursday 19, Jan 2012

  Clomid

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Clomid is a popularly referred brand name for the drug Clomiphene or Clomifene. It is a selected estrogen receptor modulator which is known to increase the production of gonadotropins.  For this reason, it is commonly prescribed to women for improving their fertility. Clomiphene citrate is the main ingredient in this estrogen which stimulates the process of ovulation in women, thereby acting as a fertility aid. Chemically it is recognized as a 2-(4-(2-chloro-1,2-diphenylethenyl-phenoxy)-N,N-diethyl-ethanamine. Clomid is also popularly marketed as Serophene and Milophene.

Clomid intake is also common amongst athletes and bodybuilders as it restores the body’s natural testosterone levels that may have been affected by use of harsh and aromatizable steroids and also avoids the occurrence of gynecomastia in post cycle therapy. This steroid is highly effective and also an inexpensive compound. It is for this reason that it is so widely sought by bodybuilders and sportsmen all over the world.

Clomid is ideally a synthetic estrogen which possesses both agonist as well as antagonist properties. Chemically its structure and action is very similar to Nolvadex. However, when ingested in the body, Clomid minimizes the effect of natural estrogen in the body. Clinically it is believed to reduce the negative feedback of estrogen on the hypothalamus, enhancing the release of FSH and LSH. It is because of this mechanism that testosterone production in men is restored. This proves to be highly beneficial for athletes when they administer it at end of their steroid cycle because during the cycle, their endogenous testosterones are usually depressed. Once the anabolic effect from the body is removed, it is important to bring the level of endogenous testosterones back to normal as inability to do so might cause what is called a post-steroid crash.  In a steroid crash, a major loss in the size and the strength of the newly acquired muscle takes place. This is because in the absence of testosterone, the catabolic cortisol hormone becomes dominant. Administration of Clomid at this point, helps avoiding this crash.

For women, the best time to use it is around the contest time when the adjustment of estrogen levels is required. Women should intake this steroid only under the supervision of a physician as excessive intake may increase fat loss as well as muscularity. In some cases, it might cause troubled effects such as poor vision. However, this may take place only when dosages become exceedingly high.

For men, the best dosage is 50 to 100 mg per day. Its administration brings testosterone production to normal levels within the period of 4 to 6 weeks. The regime followed by professionals is 100 mg from day 1 to 11 and 50 mg from days 12 to 21. The restoration of testosterone levels is however, gradual. To achieve an immediate effect, Clomid is often ingested with Human Chorionic Gonadotropin (HCG) for the first two weeks after the anabolic steroid intake is discontinued. This combined intake also aids in restoring the normal ability of the testicles’ responsiveness to endogenous LH. After HCG’s administration along with Clomid is stopped, the user may continue to take Clomid for a certain period. It must be mentioned here that the use of HCG should not exceed more than 2-3 weeks as it may it may initiate the negative feedback inhibition on the hypothalamic-pituitary axis. Also Clomid intake in injectable form has an effect more long lasting in an ancillary drug program. It is also observed that if HCG and Clomid are taken periodically in a steroid cycle, the natural testosterone level can be prevented from reducing. Usage of strong androgens should be avoided for a prolonged period of time. Some bodybuilders take these drugs alternatively, sometimes even after long intervals for the fear of losing their effectiveness if taken together.

Another drug that is widely used in combination with Clomid is Proviron. Proviron is an oral DHT which considerably lowers the aromatase activity in the body, thereby raising the estrogen to androgen ratio. Clomid’s association with Proviron has been proved to be extremely effective. However, it can also be combined with certain specific inhibitors such as Aromasin, Femara, and Arimidex.

A factor that makes Clomid such a popular drug is that it is very safe. Bodybuilders reporting its side effects (after excessive intake) have been very few.  Some common ones include nausea, dizziness, headaches, and hot flushes. Hence over-dose is strictly not recommended. This popular estrogen is widely available in the market under a vast range of brand names. Its popular forms are tablets and injectables.

Saturday 15, Jan 2011

  Steroid hormone can alleviate brain’s response to stress

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Steroid hormone can alleviate brain's response to stressA steroid hormone, known as Progesterone metabolite allopregnanolone, which gets released during the metabolism of progesterone (the female sex hormone) can minimize brain’s response to stress.

The scientists found evidence suggesting that the human brain’s response to a peptide hormone that plays an important role in the stress response in animals, corticotropin-releasing factor (CRF), gets reduced by progesterone metabolite allopregnanolone.

The finding was disclosed by scientists at Emory University School of Medicine, the Yerkes National Primate Research Center, and Atlanta’s Center for Behavioral Neuroscience.

Friday 17, Sep 2010

  Progesterone metabolite allopregnanolone minimized stress

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Progesterone metabolite allopregnanolone minimized stressProgesterone metabolite allopregnanolone, a steroid hormone released during the metabolism of progesterone (the female sex hormone) has the ability to reduce response of the brain to stress.

This finding was disclosed by scientists at Emory University School of Medicine, the Yerkes National Primate Research Center, and Atlanta’s Center for Behavioral Neuroscience.

Evidence was found by the scientists in context to the fact that response of brain to corticotropin-releasing factor (CRF), a peptide hormone that plays an important role in the stress response in animals, was reduced by progesterone metabolite allopregnanolone.

Monday 23, Aug 2010

  Airway constriction in asthmatic women patients reduces with estrogen

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Airway constriction in asthmatic women patients reduces with estrogenAccording to new bench research from the Mayo Clinic, female sex hormones could work with beta-agonists in minimizing airway constriction.

Lead student researcher, Elizabeth A. Townsend, of the Mayo Clinic Department of Physiology and Biomedical Engineering, said that it will be of interest to ascertain whether sex steroids such as estrogen and progesterone play a role in modulation of airway tone.

The findings are being presented at the ATS 2010 International Conference in New Orleans.

Saturday 10, Jul 2010

  Premenstrual depression and genetic variations found interlinked

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Premenstrual depression and genetic variations found interlinkedThere is a possible interlinking between genetic variations and the increased risk for severe premenstrual depression, according to findings disclosed by scientists at the University of North Carolina at Chapel Hill and the National Institute of Mental Health.

The psychiatric condition, which is known as premenstrual dysphoric disorder (PMDD) affects approximately eight percent of women in their child-bearing years. This condition is characterized by severe anxiety and irritability during second half of the menstrual cycle.

Dr. David R. Rubinow, the study’s senior author and the Meymandi distinguished professor and chair of psychiatry at UNC School of Medicine, was of the view that this study could possibly help find out important clues about why some women experience mood swings while others do not.

Monday 21, Jun 2010

  Severe premenstrual depression could be associated with genetic differences

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Severe premenstrual depression could be associated with genetic differencesSevere premenstrual dysphoric disorder, or PMDD, tends to affect approximately eight percent of women in their child-bearing years. The disorder is characterized by anxiety and severe irritability during second half of the menstrual cycle.

Scientists at the University of North Carolina at Chapel Hill and the National Institute of Mental Health have found that there could be a possible association between this disorder and specific genetic variations.

It was remarked by Dr. David R. Rubinow, the study’s senior author and the Meymandi distinguished professor and chair of psychiatry at UNC School of Medicine that this study offers implications as to why some women experience mood swings and what is the nature of this susceptibility.

Saturday 12, Jun 2010

  Hormone replacement in joint fluid complemented with positive regenerative effect

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Hormone replacement in joint fluid complemented with positive regenerative effectAccording to researchers from Germany, concentrations of testosterone in men and estrogen in women could have a positive effect on the regenerative potential of cartilage tissue.

In a study, it was suggested that hormone replacement in the joint fluid of men and women could be beneficial to treat late stages of human osteoarthritis (OA) by regenerating damaged tissue.

Results of this evidence-based study appeared in an issue of Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology.

Sunday 02, May 2010

  Risks of anti-aging hormones outweigh benefits

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Risks of anti-aging hormones outweigh benefitsIn the wake of the recently released report by the American Medical Association’s (AMA) Council on Science and Public Health, Dr. Thomas T. Perls, an associate professor of medicine at Boston University School of Medicine has criticized the promotion and distribution of growth hormones that are used for purposes other than medical.

In an editorial appearing in the Future Medicine journal Aging Health, Dr. Perls applauded the courage shown by the AMA in its recently published assessment of risks and benefits of growth hormone, DHEA, estrogen, and testosterone for anti-aging.

Dr. Perls denounced the marketing of hormones, especially growth hormone and anabolic steroids, for the purpose of anti-aging.

Wednesday 28, Apr 2010

  Potential regenerative effect seen by hormone replacement in joint fluid

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Potential regenerative effect seen by hormone replacement in joint fluidConcentrations of the sex hormones, testosterone in men and estrogen in women can have a positive effect on the regenerative potential of cartilage tissue as per German researchers.

It was suggested by the study that hormone replacement in the joint fluid of men and women can be advantageous for treating late stages of human osteoarthritis (OA) by regenerating damaged tissue.

Details of this evidence-based study appeared in an issue of Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology.

Monday 26, Apr 2010

  Testosterone levels possible of getting elevated with Androstenedione

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Testosterone levels possible of getting elevated with AndrostenedioneA dietary supplement used by some athletes, Androstenedione, when administered in dosages of 300 milligram (mg) may increase the blood testosterone levels in healthy young men, according to a study. It was also disclosed that both 100 and 300 mg doses of this supplement can also promote estrogen level increases. The study, however, did not examined if androstenedione has long-term side effects or of it can aid muscle mass or strength gains.

The study was led by researchers from the Massachusetts General Hospital (MGH) and reported in the Feb. 9 issue of the Journal of the American Medical Association.

Joel Finkelstein, MD, of the MGH Endocrine Unit, the report’s senior author, remarked that this is the first of its kind study to disclose that sufficient doses of Androstenedione can increase serum testosterone.

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