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Saturday 03, Apr 2010

  Risks of stridor and reintubation can be reduced with early steroid use

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Risks of stridor and reintubation can be reduced with early steroid useThe risks of reintubation and stridor can be reduced to a significant extent in high-risk patients with administration of steroids at least four hours before extubation, as per a report.

Dr. Samir Jaber from University of Montpellier I in France and colleagues conducted a quantitative meta-analysis of seven studies and find out the efficacy of prophylactic steroid therapy to prevent reintubation and post-extubation stridor.

It was suggested by the study that steroid treatment is beneficial for reducing the risk of reintubation in trials that enrolled high-risk patients.

Thursday 05, Nov 2009

  Early Steroid usage in high-risk patients can minimize stridor and reintubation

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Early Steroid usage in high-risk patients can minimize stridor and reintubationThe risk of stridor and reintubation in selected high-risk patients can be minimized to a considerable extent by administering steroids at least four hours before extubation, as per a recent report.

Dr. Samir Jaber from University of Montpellier I in France and colleagues conducted a quantitative meta-analysis of seven studies for identifying the effectiveness of prophylactic steroid therapy in inhibiting reintubation and post-extubation stridor. It is noteworthy to remember that this identification process took the at-risk populations and steroid administration regimen into account.

It was suggested during the study that the prophylactic steroid therapy is still controversial in both selected and non-selected patients when it comes to preventing post-extubation stridor and reintubation.

It was indicated during the study that reintubation risk in trials enrolling high-risk patients was minimized with steroid treatment but the minimized risk was not well-defined when the conducted trials did not select patients for reintubation risk.


Monday 15, Jun 2009

  Reintubation and Stridor to be minimized with Early Steroid Use in High-Risk Patients

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Reintubation and Stridor to be minimized with Early Steroid Use in High-Risk PatientsAccording to a report, the risks of reintubation and stridor in selected high-risk patients can be reduced when steroids are administered to them at least four hours before extubation.

Dr. Samir Jaber from University of Montpellier I in France and colleagues conducted a quantitative meta-analysis of seven studies with an aim to identify the effectiveness of prophylactic steroid therapy for preventing reintubation and post-extubation stridor. This identification took into account the at-risk populations and the steroid administration regimen.

However, it was revealed that prophylactic steroid therapy with an aim to prevent post-extubation stridor and reintubation is still controversial in both selected and non-selected patients.

The study indicated that the risk of reintubation in trials that enrolled high-risk patients got reduced with steroid treatment. But, the risk reduction was not completely well-defined when the conducted trials did not select patients for reintubation risk.

Thursday 28, May 2009

  Hydrocortisone Used To Wean Off Patients from Ventilator Faster

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Hydrocortisone Used To Wean Off Patients from Ventilator FasterPatients who have low levels of adrenal are supposed to be weaned off early from ICU if they are given a supplement of hydrocortisone before extubation is attempted.

Study was conducted on 93 critically ill patients, 91.4% of the 70 with relative adrenal insufficiency who received hydrocortisone infusions were successfully weaned from a ventilator, compared with 68.8% of those who received a saline placebo.

This stress dose corticosteroid supplementation with adrenal insufficiency led to a significantly higher success rate for ventilator weaning. Functional adrenal insufficiency was related to subnormal corticosteroid production during critical illness, particularly septic shock, in the absence of structural defects in the hypothalamic-pituitary-adrenal axis.

The patients were given regular corticosteroids before or during the admission. Patients with adrenal insufficiency were given 50 mg intravenous hydrocortisone every six hours during the weaning period. Studies showed that 32 of 35 patients taking hydrocortisone were successfully taken off ventilators, compared with 24 of 35 in the control group. Among the 20 patients with adequate adrenal reserves, 20 of 20 patients were taken off ventilator, but three failed after extubation.

Studies conclude that the weaning period was shorter in the hydrocortisone treatment group than in the placebo group. They also noted that “No significant adverse effects were observed in the corticosteroid treatment group.”