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Tuesday 08, Aug 2017

  French Open Finalist Banned For Doping Violation

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The International Tennis Federation (ITF) has banned Italian player Sara Errani for two months for an anti-doping violation.

The 29-year-old former French Open finalist failed the out-of-competition test in February after a urine sample was found to contain Letrozole. Also known as Femara, Letrozole is a substance used in the treatment of breast cancer. The substance is also on the banned drug list of the World Anti-Doping Agency (WADA). The aromatase inhibitor can act as a hormonal and metabolic stimulant.

In a statement, the ITF said the former French Open finalist was charged with an Anti-Doping violation on April 18 and had promptly asked for a hearing before an Independent Tribunal.

The former world number five said she did not knowingly commit a doping violation. Errani expressed anger over the suspension of two months imposed on her. The tennis player admitted to an anti-doping rule violation when a charge was brought by the world governing body of tennis but her plea of no fault or negligence was rejected by an independent tribunal. It was argued by Errani that she ingested the prohibited substance inadvertently through the anti-cancer medication of her mother while she was staying at the house of her parents. Errani also remarked an examination of her hair suggests the quantity of the substance she ingested was less than is contained in a single ‘Femara’ pill. However, it was unable to be submitted as evidence in her hearing.

The Italian player added she had never used a prohibited substance in her life and in career. Errani added she has zealously stuck to the World Anti-Doping Agency program ever since she became professional and had never asked for an exemption, not even when she could have when she was ill. Errani added it has been scientifically verified that the amount of a dose even or superior of the quantity contained in a single pill of ‘Femara’ produces a quantity of Letrozole traceable in the hair of the one who ingested it. She went on to remark that there was no trace in her hair that proves that the quantity she involuntarily ingested was inferior to the single tablet and could reasonably lead to an accidental ingestion. Errani also commented that these results have not been admitted as evidence in her favor because of a legal issue and added she offered a detailed report to the tribunal which had said that food contamination is the cause for her failed doping test. She added there is no evidence that she had intentionally breached anti-doping laws and also remarked there is no evidence that Letrozole could enhance the performance of a female tennis player.

Errani said the independent tribunal still sanctioned her with a two-month ban which will end on October 2, 2017, including a revocation of the prize money and the ranking points earned between the February 16 and June 7. The tennis player hit out at media and said she felt her case was incorrectly reported. Errani said to media that she hopes that tomorrow the professionalism of all of them who have written false things, unleashing the rage of all those who hide behind a social media keyboard accusing her of everything and trying to ruin her reputation, have the courage and the intellectual honesty to publish a rectified version of their recent headlines.

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Saturday 07, Apr 2012

  Femara- Letrozole

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If you are looking for a potent antiestrogen that is second to none for controlling or preventing the formation of excess estrogens, Femara, also known as Liquifem and Letrozole, is the best non-steroidal aromatase inhibitor. Medically used for treating hormonally responsive breast cancer after surgery, Femara is used by sportsmen to control excess estrogen formation, just before the end or after the end of a steroid cycle involving harsh or aromatizable anabolic steroids.

Since this antiestrogen has the unique ability of minimizing the level of estrogen the human body produces, it helps sportsmen stay away from side effects of estrogens like bloating, gynecomastia, and oily skin. Femara is also useful to extend help to users when it comes to reaping and optimizing benefits of anabolic steroids during a steroid cycle besides promoting spermatogenesis in male patients suffering from non-obstructive azoospermia and treating endometriosis. If that was not all, the antiestrogen is also useful in promoting growth hormone, cortisol, SHBG, hepatic production of binding proteins, HDL, and growth and development of sexual characteristics.

The recommended dose of Letrozole for treating breast cancer patients is 2.5 mg once in a day and sportsmen often use the drug in doses of 0.25-1.0 mg per day, with or without meals. Letrozole abuse may lead to side effects including loss of appetite, headache, stomach pain, cough, hot flushes, night sweats, vomiting, and breast pain.

Letrozole use is extremely helpful in reaping benefits of “good” estrogens like healthy immune function, healthy cholesterol levels, joint health, cognitive function, and muscle growth while “bad” estrogens are eliminated by Femara to help users stay away from estrogen side effects (excess estrogen side effects) like oily skin, acne, and gynecomastia.

Saturday 04, Feb 2012

  Femara-Letrozole

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Femara, also known as Liquifem and Letrozole, is an oral non-steroidal aromatase inhibitor used medically to treat hormonally responsive breast cancer after surgery. Professional sportsmen use Femara for controlling or preventing the formation of excess estrogens, especially after undergoing a steroid cycle involving use of harsh or aromatizable anabolic steroids (especially testosterone derivatives) and performance enhancing drugs.

Femara tablets contain a non-steroidal aromatase inhibitor, letrozole, and inactive tablet ingredients include magnesium stearate, maize starch, microcrystalline cellulose, colloidal silicon dioxide, ferric oxide, hydroxypropyl methylcellulose, lactose monohydrate, polyethylene glycol, sodium starch glycolate, talc, and titanium dioxide. The chemical name of Femara is 4, 4’-(1H-1, 2, 4-Triazol-1ylmethylene) dibenzonitrile and it has the molecular weight of 285.31 g/mol at the base. Letrozole has the molecular formula of C17H11N5.

Letrozole is one of the most trusted drugs for treating specific types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause besides proving its usefulness in preventing the cancer from making a return. Since this drug reduces the amount of estrogen the human body makes, it is admired by sportsmen as use of the drug helps them stay away from bloating and estrogenic side effects such as gynecomastia and oily skin. In addition to all these advantages, Letrozole use is also associated with the promotion of spermatogenesis in male patients suffering from non-obstructive azoospermia and treating endometriosis. Femera is also useful in extending help to sportsmen optimize benefits of anabolic steroids, including the promotion of growth hormone, cortisol, SHBG, hepatic production of binding proteins, HDL, and promotion of the growth and development of sexual characteristics.

Letrozole use prevents only ‘harmful estrogen’ and helps the body retain the ‘good estrogen.’ This means that sportsmen using Femara (Letrozole) can still reap benefits of estrogens like healthy immune function, healthy cholesterol levels, joint health, cognitive function, and muscle growth while staying away from bad estrogen side effects (excess estrogen side effects) such as oily skin, acne, and gynecomastia.

The recommended dose of Letrozole (Femara) to treat breast cancer is 2.5 mg once in a day and sportsmen use Liquifem in doses of 0.25-1.0 mg per day, with or without meals. Letrozole abuse can lead to side effects such as loss of appetite, headache, stomach pain, cough, hot flushes, night sweats, vomiting, and breast pain.

Thursday 19, Jan 2012

  Clomid

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Clomid is a popularly referred brand name for the drug Clomiphene or Clomifene. It is a selected estrogen receptor modulator which is known to increase the production of gonadotropins.  For this reason, it is commonly prescribed to women for improving their fertility. Clomiphene citrate is the main ingredient in this estrogen which stimulates the process of ovulation in women, thereby acting as a fertility aid. Chemically it is recognized as a 2-(4-(2-chloro-1,2-diphenylethenyl-phenoxy)-N,N-diethyl-ethanamine. Clomid is also popularly marketed as Serophene and Milophene.

Clomid intake is also common amongst athletes and bodybuilders as it restores the body’s natural testosterone levels that may have been affected by use of harsh and aromatizable steroids and also avoids the occurrence of gynecomastia in post cycle therapy. This steroid is highly effective and also an inexpensive compound. It is for this reason that it is so widely sought by bodybuilders and sportsmen all over the world.

Clomid is ideally a synthetic estrogen which possesses both agonist as well as antagonist properties. Chemically its structure and action is very similar to Nolvadex. However, when ingested in the body, Clomid minimizes the effect of natural estrogen in the body. Clinically it is believed to reduce the negative feedback of estrogen on the hypothalamus, enhancing the release of FSH and LSH. It is because of this mechanism that testosterone production in men is restored. This proves to be highly beneficial for athletes when they administer it at end of their steroid cycle because during the cycle, their endogenous testosterones are usually depressed. Once the anabolic effect from the body is removed, it is important to bring the level of endogenous testosterones back to normal as inability to do so might cause what is called a post-steroid crash.  In a steroid crash, a major loss in the size and the strength of the newly acquired muscle takes place. This is because in the absence of testosterone, the catabolic cortisol hormone becomes dominant. Administration of Clomid at this point, helps avoiding this crash.

For women, the best time to use it is around the contest time when the adjustment of estrogen levels is required. Women should intake this steroid only under the supervision of a physician as excessive intake may increase fat loss as well as muscularity. In some cases, it might cause troubled effects such as poor vision. However, this may take place only when dosages become exceedingly high.

For men, the best dosage is 50 to 100 mg per day. Its administration brings testosterone production to normal levels within the period of 4 to 6 weeks. The regime followed by professionals is 100 mg from day 1 to 11 and 50 mg from days 12 to 21. The restoration of testosterone levels is however, gradual. To achieve an immediate effect, Clomid is often ingested with Human Chorionic Gonadotropin (HCG) for the first two weeks after the anabolic steroid intake is discontinued. This combined intake also aids in restoring the normal ability of the testicles’ responsiveness to endogenous LH. After HCG’s administration along with Clomid is stopped, the user may continue to take Clomid for a certain period. It must be mentioned here that the use of HCG should not exceed more than 2-3 weeks as it may it may initiate the negative feedback inhibition on the hypothalamic-pituitary axis. Also Clomid intake in injectable form has an effect more long lasting in an ancillary drug program. It is also observed that if HCG and Clomid are taken periodically in a steroid cycle, the natural testosterone level can be prevented from reducing. Usage of strong androgens should be avoided for a prolonged period of time. Some bodybuilders take these drugs alternatively, sometimes even after long intervals for the fear of losing their effectiveness if taken together.

Another drug that is widely used in combination with Clomid is Proviron. Proviron is an oral DHT which considerably lowers the aromatase activity in the body, thereby raising the estrogen to androgen ratio. Clomid’s association with Proviron has been proved to be extremely effective. However, it can also be combined with certain specific inhibitors such as Aromasin, Femara, and Arimidex.

A factor that makes Clomid such a popular drug is that it is very safe. Bodybuilders reporting its side effects (after excessive intake) have been very few.  Some common ones include nausea, dizziness, headaches, and hot flushes. Hence over-dose is strictly not recommended. This popular estrogen is widely available in the market under a vast range of brand names. Its popular forms are tablets and injectables.