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Monday 03, Jan 2011

  Gene activity is influenced by steroid hormones

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Gene activity is influenced by steroid hormonesScientists at the University of Bristol and the National Cancer Institute (NCI), USA have revealed that the manner in which gene expression takes place in rodents is affected by intermittent signaling by steroid hormones.

This finding is considered to have critical implications to understand how steroids work and how they can assist in opening up novel avenues for development of new therapies.

The research appeared online and appeared in the September 2009 issue of Nature Cell Biology.

Monday 28, Jun 2010

  Steroid hormones have influence on activity of genes

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Steroid hormones have influence on activity of genesThe manner in which genes are expressed in rodents is affected by intermittent signaling by steroid hormones, according to a research by scientists at the University of Bristol and the National Cancer Institute (NCI), USA.

The research appeared online and appeared in the September 2009 issue of Nature Cell Biology.

The finding is expected to have implications for understanding how steroids work and can help in opening up novel avenues for development of new therapies.

Monday 17, May 2010

  Increased blood flow found associated with healthy blood vessels

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Increased blood flow found associated with healthy blood vesselsA new way has been identified by scientists that can help people stay protected against heart diseases by emphasizing upon exercises.

According to researchers at the University of Pennsylvania’s Institute for Medicine and Engineering, increased blood flow has the ability to mimic the powerful anti-inflammatory actions of specific glucocorticoid steroid drugs.

It was discovered by the researchers that an increase in shear stress, which can be classified as the drag force exerted by blood flowing over endothelial cells that line blood vessels, leads to the same sort of anti-inflammatory events that are normally associated with high doses of steroids.

Sunday 09, May 2010

  Children with lower respiratory infections not able to find relief with steroid medications

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Children with lower respiratory infections not able to find relief with steroid medicationsYoung children suffering with bronchiolitis, a common viral lower respiratory infection in infants, are not able to find any relief with medications based on steroids, as per a study published in an issue of the New England Journal of Medicine.

This finding by the Pediatric Emergency Care Applied Research Network (PECARN) resolved controversy from past research and is considered to guide during treatment for the most common cause of infant hospitalization.

Howard M. Corneli, M.D., professor of pediatrics at the University of Utah and the principal investigator on the study, said that glucocorticoids (a form of steroids) do not prove effective for treating bronchiolitis and future efforts must be focused upon better treatments and better preventive strategies.

Wednesday 30, Dec 2009

  Gene activity affected by steroid hormones

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Gene activity affected by steroid hormonesAs per a research by scientists at the University of Bristol and the National Cancer Institute (NCI), USA, gene activity can be affected via intermittent signaling by steroid hormones.

These findings were published online and appeared in the September 2009 issue of Nature Cell Biology.

It is believed that this finding would have major implications to ascertain how steroids work besides opening novel avenues to new therapies.

It is considered by members of the medical fraternity that such studies would help in defining the potential role of ultradian application of glucocorticoid receptor therapy to a significant extent.

Thursday 17, Dec 2009

  Steroid-induced osteoporosis is treatable with Teriparatide

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Steroid-induced osteoporosis is treatable with TeriparatideGlucocorticoid-induced osteoporosis (OP) is now very much treatable with Teriparatide, a synthetic form of the human parathyroid hormone, as per a recent study.

The involved researchers found that patients with glucocorticoid-induced osteoporosis and administered with teriparatide for a period of 36 months had a greater increase in bone mineral density apart from fewer new vertebral fractures than those treated with alendronate.

The study findings were published in the November issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR). The 36-month randomized, double-blind, and controlled trial was conducted at 76 centers located in 13 countries and led by Kenneth Saag, M.D., from the University of Alabama.

Dr. Saag commented that there are a considerable number of individuals treated regularly with steroids for controlling inflammation that puts them at risk for developing osteoporosis and teriparatide is a safe and effective treatment for patients with steroid-induced osteoporosis.

Friday 22, May 2009

  STEROIDS EFFECTIVE IN RHEUMATOID ARTHRITIS

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STEROIDS EFFECTIVE IN RHEUMATOID ARTHRITISThere had been significant development in the life of the people suffering from the rheumatoid arthritis as the steroids were used with the standard treatment According to the sources, low doses of steroids can inhibit joint damage, if used in the early stage of rheumatoid arthritis.

Rheumatoid arthritis is a chronic disease in which the body’s immune system attacks and destroys healthy joint tissue. The hands and feet are generally affected, and as the disease progresses it can cause pain, swelling, deformity and disability.

The steroids used in the treatment are called as glucocorticoids and it also includes the well-known anti-inflammatory prednisone. This medication is generally suggested in the first few months after diagnosis to relieve the discomfort of RA until slower-acting drugs begin protecting the joints.

Quality evidence supports medication of combining the pills with standard medications in the first two years after diagnosis. Sources say that the research was conducted by the scientists which had 15 studies including 1,414 patients. In most of the cases, patients were given low doses of glucocorticoid pills along with disease-modifying drugs for one to two years.

Periodic X-rays showed the extent of joint erosion and other signs of damage a bit less than what it was before staring with the treatment.

On the basis of the report by the sources it can be conclude that if people are put on the lowest possible dose of steroids it can get them off it as soon as possible. Glucocorticoid pills are really effective in treatment of the rheumatoid arthritis.

Wednesday 31, Dec 2008

  Two more dopers caught before 2008 ends

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urine-test-steroidsSports organizations net two athletes for violation of anti-doping policies.
Soccer player Eduardo Carlos Morgado Oliveira tested positive for the anabolic steroid nandrolone after the Russia-Italy matchup at the FIFA Futbal World Cup Brazil 2008 on Oct.18.

Meanwhile Liberian player Melvin King received a five-month ban subsequent to a positive test at a doping control after the match of the preliminary competition of the 2010 FIFA World Cup between Senegal and Liberia. The match took place on 21 June 2008. King was discovered of using a glucocorticoid, which is a medication included in the list of specified substances of WADA.

The use of such a substance requires a therapeutic use exemption, something which the player did not have. The sanctions for such an anti-doping rule violation range from a warning to a two-year suspension, and the FIFA Disciplinary Committee decided to impose a sanction of five months starting on 2 October 2008, the date on which the player was first provisionally suspended by the chairman of the FIFA Disciplinary Committee. The sanction applies for all matches, whether friendly or official fixtures, at domestic and international level.